Angiogenesis induced in vivo by hepatocyte growth factor is mediated by platelet-activating factor synthesis from macrophages

This study shows that the neoangiogenesis induced by hepatocyte growth factor (HGF) was associated with a local synthesis of platelet-activating factor (PAF) and was inhibited by the specific PAF receptor antagonist WEB 2170 in a murine model in which matrigel was injected s.c. as a substratum for a...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-02, Vol.158 (3), p.1302-1309
Hauptverfasser:	Camussi, G, Montrucchio, G, Lupia, E, Soldi, R, Comoglio, PM, Bussolino, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azepines - pharmacology Cattle Cell Movement Cells, Cultured Chemotaxis, Leukocyte Collagen Drug Combinations Hepatocyte Growth Factor - physiology Humans Laminin Macrophages, Peritoneal - physiology Mice Mice, Inbred C57BL Neovascularization, Physiologic Phosphotyrosine - metabolism Platelet Activating Factor - physiology Platelet Membrane Glycoproteins - antagonists & inhibitors Proteoglycans Proto-Oncogene Proteins c-met Receptor Protein-Tyrosine Kinases - metabolism Receptors, Cell Surface Receptors, G-Protein-Coupled Signal Transduction Triazoles - pharmacology
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