HIV transmission by transplantation of allograft skin: a review of the literature

The fear of human immunodeficiency virus (HIV) transmission by means of allograft skin has led to a cautious approach to allograft donor selection. However, no irrefutable diagnostic test exists to determine the possible presence of HIV at the time of donation. In order to find ways of improving HIV...

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Veröffentlicht in:Burns 1997-02, Vol.23 (1), p.1-5
Hauptverfasser: Pirnay, J.P., Vandenvelde, C., Duinslaeger, L., Reper, P., Vanderkelen, A.
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container_end_page 5
container_issue 1
container_start_page 1
container_title Burns
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creator Pirnay, J.P.
Vandenvelde, C.
Duinslaeger, L.
Reper, P.
Vanderkelen, A.
description The fear of human immunodeficiency virus (HIV) transmission by means of allograft skin has led to a cautious approach to allograft donor selection. However, no irrefutable diagnostic test exists to determine the possible presence of HIV at the time of donation. In order to find ways of improving HIV donor screening practices for skin banks, we review the presence of HIV in human skin, explore the possible transmission of HIV by transplantation of human allograft skin, and discuss the reliability of existing HIV tests. The use of the polymerase chain reaction (PCR) as a sensitive detection system for HIV infection of skin biopsies, in combination with conventional routine HIV blood screening tests, could lower the risk of transmitting HIV to severely burned patients.
doi_str_mv 10.1016/S0305-4179(96)00081-2
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source MEDLINE; Elsevier ScienceDirect Journals
subjects AIDS/HIV
Biological and medical sciences
Guidelines as Topic
HIV Infections - etiology
HIV Infections - prevention & control
HIV Infections - transmission
human immunodeficiency virus
Humans
Mass Screening - methods
Medical sciences
Primary Prevention - methods
Risk Factors
Skin plastic surgery
Skin Transplantation - adverse effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Transplantation, Homologous - adverse effects
title HIV transmission by transplantation of allograft skin: a review of the literature
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