Evidence for Specific Proteolytic Cleavage of the N-Terminal Domain of Human Profilaggrin During Epidermal Differentiation

Profilaggrin is a large phosphoprotein that is expressed in the granular cells of epidermis where it is localized in keratohyalin. It consists of multiple copies of single filaggrin units plus N- and C-terminal sequences that differ from filaggrin. Profilaggrin is dephosphorylated and proteolyticall...

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Veröffentlicht in:	Journal of investigative dermatology 1997-02, Vol.108 (2), p.170-178
Hauptverfasser:	Presland, Richard B., Kimball, Janet R., Kautsky, Mikael B., Patrick Lewis, S., Lo, Christine Y., Dale, Beverly A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Biological and medical sciences Cell Differentiation Cells, Cultured DNA, Complementary - analysis Endopeptidases - metabolism Epidermal Cells epidermis Fundamental and applied biological sciences. Psychology Gene Expression Humans Immunoblotting Immunohistochemistry Intermediate Filament Proteins - chemistry Intermediate Filament Proteins - genetics Keratinocytes - cytology Molecular Sequence Data Mouth Mucosa - cytology Peptides - metabolism profilaggrin Protein Precursors - chemistry Protein Precursors - genetics Protein Structure, Tertiary proteolytic processing Vertebrates: skin, associated glands, phaneres, light organs, various exocrine glands (salt gland, uropygial gland...), adipose tissue, connective tissue
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