Growth hormone response to growth hormone-releasing factor in depression
A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine had led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypot...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1988, Vol.9, p.113-116 |
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| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 9 |
| creator | Krishnan, K.Ranga R. Manepalli, Ananth N. Ritchie, James C. Rayasam, Krishniah Melville, Mary Lou Thorner, Michael O. Rivier, Jean E. Vale, Wylie W. Nemeroff, Charles B. |
| description | A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine had led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients. |
| doi_str_mv | 10.1016/0196-9781(88)90234-3 |
| format | Article |
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This blunted growth hormone response to clonidine had led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(88)90234-3</identifier><identifier>PMID: 2856637</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Depression ; Depressive Disorder - physiopathology ; Growth hormone (GH) ; Growth Hormone - metabolism ; Growth hormone-releasing factor (GHRF) ; Growth Hormone-Releasing Hormone ; Humans</subject><ispartof>Peptides (New York, N.Y. : 1980), 1988, Vol.9, p.113-116</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-2b96d38f8e70a612823ef6a625c877c0ed5de0e89241f84da1cf2e73d87e396b3</citedby><cites>FETCH-LOGICAL-c272t-2b96d38f8e70a612823ef6a625c877c0ed5de0e89241f84da1cf2e73d87e396b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(88)90234-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2856637$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krishnan, K.Ranga R.</creatorcontrib><creatorcontrib>Manepalli, Ananth N.</creatorcontrib><creatorcontrib>Ritchie, James C.</creatorcontrib><creatorcontrib>Rayasam, Krishniah</creatorcontrib><creatorcontrib>Melville, Mary Lou</creatorcontrib><creatorcontrib>Thorner, Michael O.</creatorcontrib><creatorcontrib>Rivier, Jean E.</creatorcontrib><creatorcontrib>Vale, Wylie W.</creatorcontrib><creatorcontrib>Nemeroff, Charles B.</creatorcontrib><title>Growth hormone response to growth hormone-releasing factor in depression</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine had led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients.</description><subject>Depression</subject><subject>Depressive Disorder - physiopathology</subject><subject>Growth hormone (GH)</subject><subject>Growth Hormone - metabolism</subject><subject>Growth hormone-releasing factor (GHRF)</subject><subject>Growth Hormone-Releasing Hormone</subject><subject>Humans</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtKAzEUhoMotVbfQGFWoovRXGaSk40gRatQcKPrME3OtJHppCZTxbd3akvBjauz-G-cj5BzRm8YZfKWMi1zrYBdAVxrykWRiwMyZKBEXjKpD8lwbzkmJym9U0qLQsOADDiUUgo1JE-TGL66RbYIcRlazCKmVWgTZl3I5n-kPGKDVfLtPKsr24WY-TZzuOoTyYf2lBzVVZPwbHdH5O3x4XX8lE9fJs_j-2luueJdzmdaOgE1oKKVZBy4wFpWkpcWlLIUXemQImhesBoKVzFbc1TCgUKh5UyMyOW2dxXDxxpTZ5Y-WWyaqsWwTkYBUNCM98Zia7QxpBSxNqvol1X8NoyaDUCzoWM2dAyA-QVoRB-72PWvZ0t0-9COWK_fbXXsn_z0GE2yHluLzke0nXHB_z_wA8YagE4</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Krishnan, K.Ranga R.</creator><creator>Manepalli, Ananth N.</creator><creator>Ritchie, James C.</creator><creator>Rayasam, Krishniah</creator><creator>Melville, Mary Lou</creator><creator>Thorner, Michael O.</creator><creator>Rivier, Jean E.</creator><creator>Vale, Wylie W.</creator><creator>Nemeroff, Charles B.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Growth hormone response to growth hormone-releasing factor in depression</title><author>Krishnan, K.Ranga R. ; Manepalli, Ananth N. ; Ritchie, James C. ; Rayasam, Krishniah ; Melville, Mary Lou ; Thorner, Michael O. ; Rivier, Jean E. ; Vale, Wylie W. ; Nemeroff, Charles B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-2b96d38f8e70a612823ef6a625c877c0ed5de0e89241f84da1cf2e73d87e396b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Depression</topic><topic>Depressive Disorder - physiopathology</topic><topic>Growth hormone (GH)</topic><topic>Growth Hormone - metabolism</topic><topic>Growth hormone-releasing factor (GHRF)</topic><topic>Growth Hormone-Releasing Hormone</topic><topic>Humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krishnan, K.Ranga R.</creatorcontrib><creatorcontrib>Manepalli, Ananth N.</creatorcontrib><creatorcontrib>Ritchie, James C.</creatorcontrib><creatorcontrib>Rayasam, Krishniah</creatorcontrib><creatorcontrib>Melville, Mary Lou</creatorcontrib><creatorcontrib>Thorner, Michael O.</creatorcontrib><creatorcontrib>Rivier, Jean E.</creatorcontrib><creatorcontrib>Vale, Wylie W.</creatorcontrib><creatorcontrib>Nemeroff, Charles B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krishnan, K.Ranga R.</au><au>Manepalli, Ananth N.</au><au>Ritchie, James C.</au><au>Rayasam, Krishniah</au><au>Melville, Mary Lou</au><au>Thorner, Michael O.</au><au>Rivier, Jean E.</au><au>Vale, Wylie W.</au><au>Nemeroff, Charles B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth hormone response to growth hormone-releasing factor in depression</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1988</date><risdate>1988</risdate><volume>9</volume><spage>113</spage><epage>116</epage><pages>113-116</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><abstract>A blunted growth hormone (GH) response to clonidine and other pharmacologic stimuli has been reported in patients with depression. This blunted growth hormone response to clonidine had led to the speculation that there is a central alpha-2 adrenergic receptor subsensitivity in depression. This hypothesis is based on the assumption that the pituitary somatotroph response to growth hormone-releasing factor (GHRF) is not altered in depression. In the present preliminary study, the somatotroph response to GHRF in depressed patients and normal controls has been evaluated in four depressed patients and four age- and sex-matched controls. The GH response to GRF is highly variable both in normal individuals and in the depressed patients studied. Larger numbers of patients and controls must be studied before any definitive conclusions can be drawn about GH responses to GRF in depressed patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2856637</pmid><doi>10.1016/0196-9781(88)90234-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 1988, Vol.9, p.113-116 |
| issn | 0196-9781 1873-5169 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Depression Depressive Disorder - physiopathology Growth hormone (GH) Growth Hormone - metabolism Growth hormone-releasing factor (GHRF) Growth Hormone-Releasing Hormone Humans |
| title | Growth hormone response to growth hormone-releasing factor in depression |
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