Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm
Deletion of the long arm of human chromosome 6 in acute lymphoblastic leukemia (ALL) has been shown by cytogenetic studies in 4-11% of cases. To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygosity (LOH) in 120 children with ALL usin...
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| Veröffentlicht in: | Leukemia 1997-02, Vol.11 (2), p.228-232 |
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| creator | GERARD, B CAVE, H GUIDAL, C DASTUGUE, N VILMER, E GRANDCHAMP, B |
| description | Deletion of the long arm of human chromosome 6 in acute lymphoblastic leukemia (ALL) has been shown by cytogenetic studies in 4-11% of cases. To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygosity (LOH) in 120 children with ALL using polymorphic markers located from the 6q14-15 chromosomal band to the telomere. LOH was detected in eight patients. A single region of LOH, flanked distally by D6S1594 and proximally by D6S301 was detected. These DNA markers are separated by 6 cM and are approximately located at the 6q21-22 band. Our present results delineate a region that is likely to contain a tumor-suppressor gene involved in a subset of childhood ALLs. |
| doi_str_mv | 10.1038/sj.leu.2400566 |
| format | Article |
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To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygosity (LOH) in 120 children with ALL using polymorphic markers located from the 6q14-15 chromosomal band to the telomere. LOH was detected in eight patients. A single region of LOH, flanked distally by D6S1594 and proximally by D6S301 was detected. These DNA markers are separated by 6 cM and are approximately located at the 6q21-22 band. Our present results delineate a region that is likely to contain a tumor-suppressor gene involved in a subset of childhood ALLs.</description><identifier>ISSN: 0887-6924</identifier><identifier>EISSN: 1476-5551</identifier><identifier>DOI: 10.1038/sj.leu.2400566</identifier><identifier>PMID: 9009085</identifier><identifier>CODEN: LEUKED</identifier><language>eng</language><publisher>London: Nature Publishing</publisher><subject>Acute lymphoblastic leukemia ; Adolescent ; Aneuploidy ; Biological and medical sciences ; Child ; Child, Preschool ; Childhood ; Children ; Chromosome 6 ; Chromosome deletion ; Chromosomes, Human, Pair 6 - genetics ; Chromosomes, Human, Pair 6 - ultrastructure ; Cytogenetics ; Deletion ; Deoxyribonucleic acid ; DNA ; Female ; Genes, Tumor Suppressor ; Genetic Markers ; Hematologic and hematopoietic diseases ; Heterozygote ; Humans ; Leukemia ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic leukemia ; Male ; Markers ; Medical sciences ; Polymerase Chain Reaction ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology ; Sequence Deletion ; Telomeres ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Leukemia, 1997-02, Vol.11 (2), p.228-232</ispartof><rights>1997 INIST-CNRS</rights><rights>Macmillan Publishers Limited 1997.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-b5df241138640d558852ac43908739ad60712287e90cf9a947dd9dc288c05f933</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2567417$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9009085$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GERARD, B</creatorcontrib><creatorcontrib>CAVE, H</creatorcontrib><creatorcontrib>GUIDAL, C</creatorcontrib><creatorcontrib>DASTUGUE, N</creatorcontrib><creatorcontrib>VILMER, E</creatorcontrib><creatorcontrib>GRANDCHAMP, B</creatorcontrib><title>Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm</title><title>Leukemia</title><addtitle>Leukemia</addtitle><description>Deletion of the long arm of human chromosome 6 in acute lymphoblastic leukemia (ALL) has been shown by cytogenetic studies in 4-11% of cases. To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygosity (LOH) in 120 children with ALL using polymorphic markers located from the 6q14-15 chromosomal band to the telomere. LOH was detected in eight patients. A single region of LOH, flanked distally by D6S1594 and proximally by D6S301 was detected. These DNA markers are separated by 6 cM and are approximately located at the 6q21-22 band. Our present results delineate a region that is likely to contain a tumor-suppressor gene involved in a subset of childhood ALLs.</description><subject>Acute lymphoblastic leukemia</subject><subject>Adolescent</subject><subject>Aneuploidy</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Chromosome 6</subject><subject>Chromosome deletion</subject><subject>Chromosomes, Human, Pair 6 - genetics</subject><subject>Chromosomes, Human, Pair 6 - ultrastructure</subject><subject>Cytogenetics</subject><subject>Deletion</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Female</subject><subject>Genes, Tumor Suppressor</subject><subject>Genetic Markers</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Heterozygote</subject><subject>Humans</subject><subject>Leukemia</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic leukemia</subject><subject>Male</subject><subject>Markers</subject><subject>Medical sciences</subject><subject>Polymerase Chain Reaction</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</subject><subject>Sequence Deletion</subject><subject>Telomeres</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>0887-6924</issn><issn>1476-5551</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkTtvFDEUhS0ECkuSlg7JEohuFr8fJQoJIAXRQG15bQ_rxR7v2jPF_nu8yigF1S3Od4_OvQeAtxhtMaLqUztsU1i2hCHEhXgBNphJMXDO8UuwQUrJQWjCXoM3rR0QuojiClxphDRSfANOX0KKU7BzLBMsI7RQQPcDupJzmdIZ-pDCHDys4c-FiBN0-5j8vhQPrVvmANM5H_dll2ybo4M9y9-Qo4UdnvcBilNfqCWXVrJN0NZ8A16NNrVwu85r8Pvh_tfdt-Hx59fvd58fB0eZnIcd9yNhGFMlGPKcK8WJdYz22JJq6wWSmBAlg0Zu1FYz6b32jijlEB81pdfg45PvsZbTEtpscmwupGSnUJZmpFJIcq47-P4_8FCWOvVshgjGhaYCoU5tnyhXS2s1jOZYY7b1bDAylyZMO5h-vVmb6AvvVttll4N_xtfXd_3DqtvmbBqrnVxszxjhQjIs6T_VQpDE</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>GERARD, B</creator><creator>CAVE, H</creator><creator>GUIDAL, C</creator><creator>DASTUGUE, N</creator><creator>VILMER, E</creator><creator>GRANDCHAMP, B</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm</title><author>GERARD, B ; CAVE, H ; GUIDAL, C ; DASTUGUE, N ; VILMER, E ; GRANDCHAMP, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-b5df241138640d558852ac43908739ad60712287e90cf9a947dd9dc288c05f933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Acute lymphoblastic leukemia</topic><topic>Adolescent</topic><topic>Aneuploidy</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Childhood</topic><topic>Children</topic><topic>Chromosome 6</topic><topic>Chromosome deletion</topic><topic>Chromosomes, Human, Pair 6 - genetics</topic><topic>Chromosomes, Human, Pair 6 - ultrastructure</topic><topic>Cytogenetics</topic><topic>Deletion</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Female</topic><topic>Genes, Tumor Suppressor</topic><topic>Genetic Markers</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Heterozygote</topic><topic>Humans</topic><topic>Leukemia</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic leukemia</topic><topic>Male</topic><topic>Markers</topic><topic>Medical sciences</topic><topic>Polymerase Chain Reaction</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology</topic><topic>Sequence Deletion</topic><topic>Telomeres</topic><topic>Tumor Cells, Cultured</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GERARD, B</creatorcontrib><creatorcontrib>CAVE, H</creatorcontrib><creatorcontrib>GUIDAL, C</creatorcontrib><creatorcontrib>DASTUGUE, N</creatorcontrib><creatorcontrib>VILMER, E</creatorcontrib><creatorcontrib>GRANDCHAMP, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GERARD, B</au><au>CAVE, H</au><au>GUIDAL, C</au><au>DASTUGUE, N</au><au>VILMER, E</au><au>GRANDCHAMP, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm</atitle><jtitle>Leukemia</jtitle><addtitle>Leukemia</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>11</volume><issue>2</issue><spage>228</spage><epage>232</epage><pages>228-232</pages><issn>0887-6924</issn><eissn>1476-5551</eissn><coden>LEUKED</coden><abstract>Deletion of the long arm of human chromosome 6 in acute lymphoblastic leukemia (ALL) has been shown by cytogenetic studies in 4-11% of cases. To characterize further the region of deletion and to precisely establish its frequency, we studied loss of heterozygosity (LOH) in 120 children with ALL using polymorphic markers located from the 6q14-15 chromosomal band to the telomere. LOH was detected in eight patients. A single region of LOH, flanked distally by D6S1594 and proximally by D6S301 was detected. These DNA markers are separated by 6 cM and are approximately located at the 6q21-22 band. Our present results delineate a region that is likely to contain a tumor-suppressor gene involved in a subset of childhood ALLs.</abstract><cop>London</cop><pub>Nature Publishing</pub><pmid>9009085</pmid><doi>10.1038/sj.leu.2400566</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute lymphoblastic leukemia Adolescent Aneuploidy Biological and medical sciences Child Child, Preschool Childhood Children Chromosome 6 Chromosome deletion Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, Pair 6 - ultrastructure Cytogenetics Deletion Deoxyribonucleic acid DNA Female Genes, Tumor Suppressor Genetic Markers Hematologic and hematopoietic diseases Heterozygote Humans Leukemia Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic leukemia Male Markers Medical sciences Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology Sequence Deletion Telomeres Tumor Cells, Cultured Tumors |
| title | Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm |
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