Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury
This study examined the behavioural and anatomical effects of intraventricular injections of nerve growth factor in rats with unilateral damage that included Zilles' areas Fr1, FL, HL, Par1 and the anterior portion of Oc2. Nerve growth factor-treated lesion rats showed attenuation of behavioura...
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| Veröffentlicht in: | Neuroscience 1997-02, Vol.76 (4), p.1139-1151 |
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| creator | Kolb, B Côté, S Ribeiro-da-Silva, A Cuello, A.C |
| description | This study examined the behavioural and anatomical effects of intraventricular injections of nerve growth factor in rats with unilateral damage that included Zilles' areas Fr1, FL, HL, Par1 and the anterior portion of Oc2. Nerve growth factor-treated lesion rats showed attenuation of behavioural symptoms in measures of forelimb function (Whishaw reaching task) and hindlimb function (beam traversing task) as well as a measure of spatial navigation (Morris water task). Analysis of dendritic arborization using a modified Golgi–Cox procedure also showed a complete reversal of lesion-induced atrophy of dendritic fields in pyramidal neurons in motor (Zilles' Fr2) and cingulate (Zilles' Cg1) cortex. In addition, there was a reversal of a lesion-induced reduction in spine density.
These results demonstrate that nerve growth factor treatment can facilitate functional recovery from cortical injury. This recovery may be mediated by a reorganization of intrinsic cortical circuitry that is reflected in changes in dendritic arborization and spine density of pyramidal neurons. |
| doi_str_mv | 10.1016/S0306-4522(96)00448-4 |
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These results demonstrate that nerve growth factor treatment can facilitate functional recovery from cortical injury. This recovery may be mediated by a reorganization of intrinsic cortical circuitry that is reflected in changes in dendritic arborization and spine density of pyramidal neurons.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/S0306-4522(96)00448-4</identifier><identifier>PMID: 9027874</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Atrophy ; Behavioral psychophysiology ; Biological and medical sciences ; Cerebral Infarction - pathology ; cortex ; Dendrites - drug effects ; Dendrites - ultrastructure ; dendritic arborization ; Forelimb - physiology ; functional recovery ; Fundamental and applied biological sciences. Psychology ; Hindlimb - physiology ; Male ; Maze Learning - physiology ; Miscellaneous ; Motor Cortex - cytology ; Motor Cortex - physiology ; Nerve Growth Factors - pharmacology ; NGF ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Pyramidal Cells - drug effects ; Pyramidal Cells - ultrastructure ; Rats ; Rats, Wistar ; Somatosensory Cortex - cytology ; Somatosensory Cortex - physiology ; Synapses - physiology ; synaptogenesis</subject><ispartof>Neuroscience, 1997-02, Vol.76 (4), p.1139-1151</ispartof><rights>1996 IBRO</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-235e890bae6e33e49439ee08bc61e4271e2cf548b809c2800c6a6fb44c13cd2d3</citedby><cites>FETCH-LOGICAL-c389t-235e890bae6e33e49439ee08bc61e4271e2cf548b809c2800c6a6fb44c13cd2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0306-4522(96)00448-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2525386$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9027874$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kolb, B</creatorcontrib><creatorcontrib>Côté, S</creatorcontrib><creatorcontrib>Ribeiro-da-Silva, A</creatorcontrib><creatorcontrib>Cuello, A.C</creatorcontrib><title>Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>This study examined the behavioural and anatomical effects of intraventricular injections of nerve growth factor in rats with unilateral damage that included Zilles' areas Fr1, FL, HL, Par1 and the anterior portion of Oc2. Nerve growth factor-treated lesion rats showed attenuation of behavioural symptoms in measures of forelimb function (Whishaw reaching task) and hindlimb function (beam traversing task) as well as a measure of spatial navigation (Morris water task). Analysis of dendritic arborization using a modified Golgi–Cox procedure also showed a complete reversal of lesion-induced atrophy of dendritic fields in pyramidal neurons in motor (Zilles' Fr2) and cingulate (Zilles' Cg1) cortex. In addition, there was a reversal of a lesion-induced reduction in spine density.
These results demonstrate that nerve growth factor treatment can facilitate functional recovery from cortical injury. This recovery may be mediated by a reorganization of intrinsic cortical circuitry that is reflected in changes in dendritic arborization and spine density of pyramidal neurons.</description><subject>Animals</subject><subject>Atrophy</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Cerebral Infarction - pathology</subject><subject>cortex</subject><subject>Dendrites - drug effects</subject><subject>Dendrites - ultrastructure</subject><subject>dendritic arborization</subject><subject>Forelimb - physiology</subject><subject>functional recovery</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hindlimb - physiology</subject><subject>Male</subject><subject>Maze Learning - physiology</subject><subject>Miscellaneous</subject><subject>Motor Cortex - cytology</subject><subject>Motor Cortex - physiology</subject><subject>Nerve Growth Factors - pharmacology</subject><subject>NGF</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Pyramidal Cells - drug effects</subject><subject>Pyramidal Cells - ultrastructure</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Somatosensory Cortex - cytology</subject><subject>Somatosensory Cortex - physiology</subject><subject>Synapses - physiology</subject><subject>synaptogenesis</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2OFCEUhYnRjO3oI0zCwhhdlPJXFKyMmfiXTHShrglFXRwmXUV7odr028tMd3orm7s434HLR8gVZ2854_rdDyaZ7lQvxGur3zCmlOnUI7LhZpDd0Cv1mGzOyFPyrJQ71k6v5AW5sEwMZlAbsvsGuAf6G_PfekujDzUjrQi-zrBUukPYt1noBMuEqaZAfcW8uz1Qv0wtznOuUChCyHvAA82RxnUJNeWF-lgBacjYan5L03K34uE5eRL9tsCL07wkvz59_Hn9pbv5_vnr9YebLkhjaydkD8ay0YMGKUFZJS0AM2PQHJQYOIgQe2VGw2wQhrGgvY6jUoHLMIlJXpJXx3vbjn9WKNXNqQTYbv0CeS1uMIYNjNsG9kcwYC4FIbodptnjwXHm7k27B9PuXqOz2j2Ydqr1rk4PrOMM07l1Utvyl6fcl_b9iH4JqZwx0YteGt2w90cMmox9AnQlJFgCTKlJrW7K6T-L_AMVUJzo</recordid><startdate>19970201</startdate><enddate>19970201</enddate><creator>Kolb, B</creator><creator>Côté, S</creator><creator>Ribeiro-da-Silva, A</creator><creator>Cuello, A.C</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970201</creationdate><title>Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury</title><author>Kolb, B ; Côté, S ; Ribeiro-da-Silva, A ; Cuello, A.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-235e890bae6e33e49439ee08bc61e4271e2cf548b809c2800c6a6fb44c13cd2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Atrophy</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Cerebral Infarction - pathology</topic><topic>cortex</topic><topic>Dendrites - drug effects</topic><topic>Dendrites - ultrastructure</topic><topic>dendritic arborization</topic><topic>Forelimb - physiology</topic><topic>functional recovery</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hindlimb - physiology</topic><topic>Male</topic><topic>Maze Learning - physiology</topic><topic>Miscellaneous</topic><topic>Motor Cortex - cytology</topic><topic>Motor Cortex - physiology</topic><topic>Nerve Growth Factors - pharmacology</topic><topic>NGF</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Pyramidal Cells - drug effects</topic><topic>Pyramidal Cells - ultrastructure</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Somatosensory Cortex - cytology</topic><topic>Somatosensory Cortex - physiology</topic><topic>Synapses - physiology</topic><topic>synaptogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kolb, B</creatorcontrib><creatorcontrib>Côté, S</creatorcontrib><creatorcontrib>Ribeiro-da-Silva, A</creatorcontrib><creatorcontrib>Cuello, A.C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kolb, B</au><au>Côté, S</au><au>Ribeiro-da-Silva, A</au><au>Cuello, A.C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>1997-02-01</date><risdate>1997</risdate><volume>76</volume><issue>4</issue><spage>1139</spage><epage>1151</epage><pages>1139-1151</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>This study examined the behavioural and anatomical effects of intraventricular injections of nerve growth factor in rats with unilateral damage that included Zilles' areas Fr1, FL, HL, Par1 and the anterior portion of Oc2. Nerve growth factor-treated lesion rats showed attenuation of behavioural symptoms in measures of forelimb function (Whishaw reaching task) and hindlimb function (beam traversing task) as well as a measure of spatial navigation (Morris water task). Analysis of dendritic arborization using a modified Golgi–Cox procedure also showed a complete reversal of lesion-induced atrophy of dendritic fields in pyramidal neurons in motor (Zilles' Fr2) and cingulate (Zilles' Cg1) cortex. In addition, there was a reversal of a lesion-induced reduction in spine density.
These results demonstrate that nerve growth factor treatment can facilitate functional recovery from cortical injury. This recovery may be mediated by a reorganization of intrinsic cortical circuitry that is reflected in changes in dendritic arborization and spine density of pyramidal neurons.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>9027874</pmid><doi>10.1016/S0306-4522(96)00448-4</doi><tpages>13</tpages></addata></record> |
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| subjects | Animals Atrophy Behavioral psychophysiology Biological and medical sciences Cerebral Infarction - pathology cortex Dendrites - drug effects Dendrites - ultrastructure dendritic arborization Forelimb - physiology functional recovery Fundamental and applied biological sciences. Psychology Hindlimb - physiology Male Maze Learning - physiology Miscellaneous Motor Cortex - cytology Motor Cortex - physiology Nerve Growth Factors - pharmacology NGF Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyramidal Cells - drug effects Pyramidal Cells - ultrastructure Rats Rats, Wistar Somatosensory Cortex - cytology Somatosensory Cortex - physiology Synapses - physiology synaptogenesis |
| title | Nerve growth factor treatment prevents dendritic atrophy and promotes recovery of function after cortical injury |
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