The acetylcholinesterase genes of C. elegans: Identification of a third gene ( ace-3) and mosaic mapping of a synthetic lethal phenotype
In C. elegans, the newly identified ace-3 is the third gene affecting acetylcholinesterase (ACNE) activity. ace-3 II specifically affects class C ACNE and is unlinked to ace-1 X or ace-2 I, which affect the other two AChE classes (A and B, respectively). Strains homozygous for an ace-3 mutation have...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1988-04, Vol.1 (2), p.165-173 |
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| creator | Johnson, Carl D. Rand, James B. Herman, Robert K. Stern, Brian D. Russell, Richard L. |
| description | In C. elegans, the newly identified
ace-3 is the third gene affecting acetylcholinesterase (ACNE) activity.
ace-3 II specifically affects class C ACNE and is unlinked to
ace-1 X or
ace-2 I, which affect the other two AChE classes (A and B, respectively). Strains homozygous for an
ace-3 mutation have no apparent behavioral or developmental defect;
ace-1 ace-3 and
ace-2 ace-3 double mutants are also nearly wild type. In contrast,
ace-1 ace-2 ace-3 triple mutant animals are paralyzed and developmentally arrested; their embryonic development is relatively unimpaired, but they are unable to grow beyond the hatching stage. Based on the analysis of genetic mosaics, we conclude that in the absence of
ace-2 and
ace-3 function, the expression of
ace-1(+) in muscle cells, but not in neurons, is essential for postembryonic viability. |
| doi_str_mv | 10.1016/0896-6273(88)90201-2 |
| format | Article |
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ace-3 is the third gene affecting acetylcholinesterase (ACNE) activity.
ace-3 II specifically affects class C ACNE and is unlinked to
ace-1 X or
ace-2 I, which affect the other two AChE classes (A and B, respectively). Strains homozygous for an
ace-3 mutation have no apparent behavioral or developmental defect;
ace-1 ace-3 and
ace-2 ace-3 double mutants are also nearly wild type. In contrast,
ace-1 ace-2 ace-3 triple mutant animals are paralyzed and developmentally arrested; their embryonic development is relatively unimpaired, but they are unable to grow beyond the hatching stage. Based on the analysis of genetic mosaics, we conclude that in the absence of
ace-2 and
ace-3 function, the expression of
ace-1(+) in muscle cells, but not in neurons, is essential for postembryonic viability.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/0896-6273(88)90201-2</identifier><identifier>PMID: 3272166</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acetylcholinesterase - genetics ; Animals ; Chromosome Mapping ; Genes, Lethal ; Mutation ; Nematoda - enzymology ; Nematoda - genetics ; Phenotype</subject><ispartof>Neuron (Cambridge, Mass.), 1988-04, Vol.1 (2), p.165-173</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c338t-e2c418c8dad4c4484aafa0ae0ac6723d0f563d2ebe2b18796af9d83ef3533e2f3</citedby><cites>FETCH-LOGICAL-c338t-e2c418c8dad4c4484aafa0ae0ac6723d0f563d2ebe2b18796af9d83ef3533e2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0896-6273(88)90201-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3272166$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Carl D.</creatorcontrib><creatorcontrib>Rand, James B.</creatorcontrib><creatorcontrib>Herman, Robert K.</creatorcontrib><creatorcontrib>Stern, Brian D.</creatorcontrib><creatorcontrib>Russell, Richard L.</creatorcontrib><title>The acetylcholinesterase genes of C. elegans: Identification of a third gene ( ace-3) and mosaic mapping of a synthetic lethal phenotype</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>In C. elegans, the newly identified
ace-3 is the third gene affecting acetylcholinesterase (ACNE) activity.
ace-3 II specifically affects class C ACNE and is unlinked to
ace-1 X or
ace-2 I, which affect the other two AChE classes (A and B, respectively). Strains homozygous for an
ace-3 mutation have no apparent behavioral or developmental defect;
ace-1 ace-3 and
ace-2 ace-3 double mutants are also nearly wild type. In contrast,
ace-1 ace-2 ace-3 triple mutant animals are paralyzed and developmentally arrested; their embryonic development is relatively unimpaired, but they are unable to grow beyond the hatching stage. Based on the analysis of genetic mosaics, we conclude that in the absence of
ace-2 and
ace-3 function, the expression of
ace-1(+) in muscle cells, but not in neurons, is essential for postembryonic viability.</description><subject>Acetylcholinesterase - genetics</subject><subject>Animals</subject><subject>Chromosome Mapping</subject><subject>Genes, Lethal</subject><subject>Mutation</subject><subject>Nematoda - enzymology</subject><subject>Nematoda - genetics</subject><subject>Phenotype</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9q3DAQxkVoSDdp3qAFnUpycKp_a8s9FMrSNIFAL-lZzErjtYotuZK2sG_Qx66dXXLsacR8v_nEfEPIe87uOOP1J6bbuqpFI2-0vm2ZYLwSZ2TFWdtUirftG7J6Rd6Sy5x_McbVuuUX5EKKRvC6XpG_zz1SsFgOg-3j4APmggky0h3Obxo7urmjOOAOQv5MHx2G4jtvofgYFhVo6X1yLzi9WawqeUshODrGDN7SEabJh92RzYdQeixze8DSw0CnHkMshwnfkfMOhozXp3pFft5_e948VE8_vj9uvj5VVkpdKhRWcW21A6esUloBdMAAGdi6EdKxbl1LJ3CLYst109bQtU5L7ORaShSdvCIfj75Tir_387Zm9NniMEDAuM-m0ZqtpWpmUB1Bm2LOCTszJT9COhjOzHIAs6RrlnSN1ublAEbMYx9O_vvtiO516JT4rH856jgv-cdjMtl6DBadT2iLcdH__4N_3AGWQQ</recordid><startdate>198804</startdate><enddate>198804</enddate><creator>Johnson, Carl D.</creator><creator>Rand, James B.</creator><creator>Herman, Robert K.</creator><creator>Stern, Brian D.</creator><creator>Russell, Richard L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198804</creationdate><title>The acetylcholinesterase genes of C. elegans: Identification of a third gene ( ace-3) and mosaic mapping of a synthetic lethal phenotype</title><author>Johnson, Carl D. ; Rand, James B. ; Herman, Robert K. ; Stern, Brian D. ; Russell, Richard L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c338t-e2c418c8dad4c4484aafa0ae0ac6723d0f563d2ebe2b18796af9d83ef3533e2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Acetylcholinesterase - genetics</topic><topic>Animals</topic><topic>Chromosome Mapping</topic><topic>Genes, Lethal</topic><topic>Mutation</topic><topic>Nematoda - enzymology</topic><topic>Nematoda - genetics</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Carl D.</creatorcontrib><creatorcontrib>Rand, James B.</creatorcontrib><creatorcontrib>Herman, Robert K.</creatorcontrib><creatorcontrib>Stern, Brian D.</creatorcontrib><creatorcontrib>Russell, Richard L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Carl D.</au><au>Rand, James B.</au><au>Herman, Robert K.</au><au>Stern, Brian D.</au><au>Russell, Richard L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The acetylcholinesterase genes of C. elegans: Identification of a third gene ( ace-3) and mosaic mapping of a synthetic lethal phenotype</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1988-04</date><risdate>1988</risdate><volume>1</volume><issue>2</issue><spage>165</spage><epage>173</epage><pages>165-173</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>In C. elegans, the newly identified
ace-3 is the third gene affecting acetylcholinesterase (ACNE) activity.
ace-3 II specifically affects class C ACNE and is unlinked to
ace-1 X or
ace-2 I, which affect the other two AChE classes (A and B, respectively). Strains homozygous for an
ace-3 mutation have no apparent behavioral or developmental defect;
ace-1 ace-3 and
ace-2 ace-3 double mutants are also nearly wild type. In contrast,
ace-1 ace-2 ace-3 triple mutant animals are paralyzed and developmentally arrested; their embryonic development is relatively unimpaired, but they are unable to grow beyond the hatching stage. Based on the analysis of genetic mosaics, we conclude that in the absence of
ace-2 and
ace-3 function, the expression of
ace-1(+) in muscle cells, but not in neurons, is essential for postembryonic viability.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3272166</pmid><doi>10.1016/0896-6273(88)90201-2</doi><tpages>9</tpages></addata></record> |
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| issn | 0896-6273 1097-4199 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acetylcholinesterase - genetics Animals Chromosome Mapping Genes, Lethal Mutation Nematoda - enzymology Nematoda - genetics Phenotype |
| title | The acetylcholinesterase genes of C. elegans: Identification of a third gene ( ace-3) and mosaic mapping of a synthetic lethal phenotype |
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