Early magnetic resonance imaging and histologic findings in a model of femoral head necrosis
The authors examined early magnetic resonance images and histologic findings of avascular necrosis of the femoral head in a canine model. The avascular necrosis of the femoral head model was surgically induced. Animals were euthanized at 3 days, 1, 2, and 4 weeks, and the proximal femurs were retrie...
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| Veröffentlicht in: | Clinical orthopaedics and related research 1997, Vol.334 (334), p.68-72 |
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| container_title | Clinical orthopaedics and related research |
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| creator | NAKAMURA, T MATSUMOTO, T NISHINO, M TOMITA, K KADOYA, M |
| description | The authors examined early magnetic resonance images and histologic findings of avascular necrosis of the femoral head in a canine model. The avascular necrosis of the femoral head model was surgically induced. Animals were euthanized at 3 days, 1, 2, and 4 weeks, and the proximal femurs were retrieved. Magnetic resonance images and histologic sections were performed on each of the specimens obtained. Twenty-five mongrel dogs were studied, 4 dogs at 3 days and 7 dogs at each of the other intervals. Findings suggest that histologic changes may be seen as early as 3 days, with marrow edema and hemorrhage as early findings, and fibrous marrow transformation and appositional bone growth as later findings. Magnetic resonance imaging abnormalities did not occur until 1 week after injury and were seen in all animals by 4 weeks. |
| doi_str_mv | 10.1097/00003086-199701000-00009 |
| format | Article |
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The avascular necrosis of the femoral head model was surgically induced. Animals were euthanized at 3 days, 1, 2, and 4 weeks, and the proximal femurs were retrieved. Magnetic resonance images and histologic sections were performed on each of the specimens obtained. Twenty-five mongrel dogs were studied, 4 dogs at 3 days and 7 dogs at each of the other intervals. Findings suggest that histologic changes may be seen as early as 3 days, with marrow edema and hemorrhage as early findings, and fibrous marrow transformation and appositional bone growth as later findings. 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The avascular necrosis of the femoral head model was surgically induced. Animals were euthanized at 3 days, 1, 2, and 4 weeks, and the proximal femurs were retrieved. Magnetic resonance images and histologic sections were performed on each of the specimens obtained. Twenty-five mongrel dogs were studied, 4 dogs at 3 days and 7 dogs at each of the other intervals. Findings suggest that histologic changes may be seen as early as 3 days, with marrow edema and hemorrhage as early findings, and fibrous marrow transformation and appositional bone growth as later findings. Magnetic resonance imaging abnormalities did not occur until 1 week after injury and were seen in all animals by 4 weeks.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diseases of the osteoarticular system</subject><subject>Dogs</subject><subject>Femur Head Necrosis - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Primary Myelofibrosis - pathology</subject><subject>Time Factors</subject><subject>Vascular bone diseases</subject><issn>0009-921X</issn><issn>1528-1132</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v3CAQRVWr7Wbbn1CJQ9WbEwaMgWMV5UuKlEsq9VDJGmPYUNmQwu4h_z44u91ruIx4897AvEcIBXYOzKgLVo9gumvAGMWg3poFMh_IGiTXDYDgH8l6gRrD4fdnclbK30XUSr4iK8OY1EatyZ8rzNMLnXEb3S5Yml1JEaN1NFQsxC3FONKnUHZpSttK8CGOFS40RIp0TqObaPLUuzllnOiTw5FGZ3MqoXwhnzxOxX091g35dX31eHnb3D_c3F3-vG9sK7pdYxRqLdlQP8S5G-xoB6aYGbT0reId4gAtamtBABc4SCGk912r_YgGNHixIT8Oc59z-rd3ZdfPoVg3TRhd2pdeac2EAv0uETrgoM1C1AfiskjJzvfPuRqSX3pg_ZJA_z-B_pTAG2Sq9Nvxjf0wu_EkPFpe-9-PfSwWJ5-r26GcaFzKjoESr3v1jcI</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>NAKAMURA, T</creator><creator>MATSUMOTO, T</creator><creator>NISHINO, M</creator><creator>TOMITA, K</creator><creator>KADOYA, M</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Early magnetic resonance imaging and histologic findings in a model of femoral head necrosis</title><author>NAKAMURA, T ; MATSUMOTO, T ; NISHINO, M ; TOMITA, K ; KADOYA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-97a8850b89722ebcdcb0709b85f4726aab14a8cc13123ab5335ff648fda9181f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diseases of the osteoarticular system</topic><topic>Dogs</topic><topic>Femur Head Necrosis - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Primary Myelofibrosis - pathology</topic><topic>Time Factors</topic><topic>Vascular bone diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NAKAMURA, T</creatorcontrib><creatorcontrib>MATSUMOTO, T</creatorcontrib><creatorcontrib>NISHINO, M</creatorcontrib><creatorcontrib>TOMITA, K</creatorcontrib><creatorcontrib>KADOYA, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical orthopaedics and related research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAKAMURA, T</au><au>MATSUMOTO, T</au><au>NISHINO, M</au><au>TOMITA, K</au><au>KADOYA, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early magnetic resonance imaging and histologic findings in a model of femoral head necrosis</atitle><jtitle>Clinical orthopaedics and related research</jtitle><addtitle>Clin Orthop Relat Res</addtitle><date>1997</date><risdate>1997</risdate><volume>334</volume><issue>334</issue><spage>68</spage><epage>72</epage><pages>68-72</pages><issn>0009-921X</issn><eissn>1528-1132</eissn><coden>CORTBR</coden><abstract>The authors examined early magnetic resonance images and histologic findings of avascular necrosis of the femoral head in a canine model. 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| ispartof | Clinical orthopaedics and related research, 1997, Vol.334 (334), p.68-72 |
| issn | 0009-921X 1528-1132 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Biological and medical sciences Diseases of the osteoarticular system Dogs Femur Head Necrosis - pathology Magnetic Resonance Imaging Medical sciences Microscopy, Electron Primary Myelofibrosis - pathology Time Factors Vascular bone diseases |
| title | Early magnetic resonance imaging and histologic findings in a model of femoral head necrosis |
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