Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing
The alternative splicing of a previously undiscovered 30 base exon confers a new level of polypeptide diversity on the N-CAM family of cell-surface glycoproteins. It results in the insertion of 10 amino acids into the fourth of five extracellular immunoglobulin-like folds. Each major size class of r...
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| Veröffentlicht in: | Neuron (Cambridge, Mass.) Mass.), 1988-12, Vol.1 (10), p.1007-1017 |
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| container_title | Neuron (Cambridge, Mass.) |
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| creator | Small, Stephen J. Haines, Susan L. Akeson, Richard A. |
| description | The alternative splicing of a previously undiscovered 30 base exon confers a new level of polypeptide diversity on the N-CAM family of cell-surface glycoproteins. It results in the insertion of 10 amino acids into the fourth of five extracellular immunoglobulin-like folds. Each major size class of rat brain N-CAM mRNAs consists of members that contain or lack the exon. Furthermore, this splicing event is developmentally controlled: RNAs containing the inserted exon are expressed at extremely low levels ( |
| doi_str_mv | 10.1016/0896-6273(88)90158-4 |
| format | Article |
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It results in the insertion of 10 amino acids into the fourth of five extracellular immunoglobulin-like folds. Each major size class of rat brain N-CAM mRNAs consists of members that contain or lack the exon. Furthermore, this splicing event is developmentally controlled: RNAs containing the inserted exon are expressed at extremely low levels (<3%) in embryonic brain but increase postnatally to 40%–45% of all N-CAM mRNAs in adult brain. Antibodies that recognize the alternative 10 amino acid segment react with a subset of N-CAM-expressing neurons in cultures of embryonic rat cells.</description><identifier>ISSN: 0896-6273</identifier><identifier>EISSN: 1097-4199</identifier><identifier>DOI: 10.1016/0896-6273(88)90158-4</identifier><identifier>PMID: 2483093</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Amino Acid Sequence ; Amino Acids - analysis ; Animals ; Base Sequence ; Brain - cytology ; Brain - metabolism ; Cell Adhesion Molecules, Neuronal - analysis ; Cell Adhesion Molecules, Neuronal - genetics ; Cell Adhesion Molecules, Neuronal - metabolism ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Epitopes - immunology ; Exons ; Gene Expression ; Immunoglobulins - immunology ; Molecular Sequence Data ; Peptides - analysis ; Peptides - immunology ; Rats ; RNA Splicing ; RNA, Messenger - analysis ; RNA, Messenger - genetics</subject><ispartof>Neuron (Cambridge, Mass.), 1988-12, Vol.1 (10), p.1007-1017</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-be5805634b6b41978f0ecb3a4937b751136c3b4a3416987301cbe2b5e68b15f03</citedby><cites>FETCH-LOGICAL-c423t-be5805634b6b41978f0ecb3a4937b751136c3b4a3416987301cbe2b5e68b15f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0896-6273(88)90158-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2483093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Small, Stephen J.</creatorcontrib><creatorcontrib>Haines, Susan L.</creatorcontrib><creatorcontrib>Akeson, Richard A.</creatorcontrib><title>Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing</title><title>Neuron (Cambridge, Mass.)</title><addtitle>Neuron</addtitle><description>The alternative splicing of a previously undiscovered 30 base exon confers a new level of polypeptide diversity on the N-CAM family of cell-surface glycoproteins. It results in the insertion of 10 amino acids into the fourth of five extracellular immunoglobulin-like folds. Each major size class of rat brain N-CAM mRNAs consists of members that contain or lack the exon. Furthermore, this splicing event is developmentally controlled: RNAs containing the inserted exon are expressed at extremely low levels (<3%) in embryonic brain but increase postnatally to 40%–45% of all N-CAM mRNAs in adult brain. Antibodies that recognize the alternative 10 amino acid segment react with a subset of N-CAM-expressing neurons in cultures of embryonic rat cells.</description><subject>Amino Acid Sequence</subject><subject>Amino Acids - analysis</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Cell Adhesion Molecules, Neuronal - analysis</subject><subject>Cell Adhesion Molecules, Neuronal - genetics</subject><subject>Cell Adhesion Molecules, Neuronal - metabolism</subject><subject>Cells, Cultured</subject><subject>Chemical Phenomena</subject><subject>Chemistry</subject><subject>Epitopes - immunology</subject><subject>Exons</subject><subject>Gene Expression</subject><subject>Immunoglobulins - immunology</subject><subject>Molecular Sequence Data</subject><subject>Peptides - analysis</subject><subject>Peptides - immunology</subject><subject>Rats</subject><subject>RNA Splicing</subject><subject>RNA, Messenger - analysis</subject><subject>RNA, Messenger - genetics</subject><issn>0896-6273</issn><issn>1097-4199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMuOFCEUhonRjD2jb6AJK6OLUiioAjYmk46OJuNloWsC1KkelIISqI699cmttjuzdHUW_-Xk_xB6RslrSmj_hkjVN30r2EspXylCO9nwB2hDiRINp0o9RJt7y2N0WcoPQijvFL1AFy2XjCi2QX--pnCYYa5-ALw32ZvqU8Q-YhPx52Z7_QnD75qNgxCWYDL207TEtAvJLsHHJvifgMcUBuwLHmAPIc0TxGpCOOAMuzVTYcD1Lqdld4dNqJDj-mMPuMzBOx93T9Cj0YQCT8_3Cn1__-7b9kNz--Xm4_b6tnG8ZbWx0EnS9Yzb3q7zhBwJOMsMV0xY0VHKescsN4zTXknBCHUWWttBLy3tRsKu0ItT75zTrwVK1ZMvx10mQlqKFlKSVgixGvnJ6HIqJcOo5-wnkw-aEn1Er49c9ZGrllL_Q6_5Gnt-7l_sBMN96Mx61d-edFhH7j1kXZyH6GDwGVzVQ_L_f_AXgVWVhg</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Small, Stephen J.</creator><creator>Haines, Susan L.</creator><creator>Akeson, Richard A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing</title><author>Small, Stephen J. ; Haines, Susan L. ; Akeson, Richard A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-be5805634b6b41978f0ecb3a4937b751136c3b4a3416987301cbe2b5e68b15f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amino Acid Sequence</topic><topic>Amino Acids - analysis</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>Cell Adhesion Molecules, Neuronal - analysis</topic><topic>Cell Adhesion Molecules, Neuronal - genetics</topic><topic>Cell Adhesion Molecules, Neuronal - metabolism</topic><topic>Cells, Cultured</topic><topic>Chemical Phenomena</topic><topic>Chemistry</topic><topic>Epitopes - immunology</topic><topic>Exons</topic><topic>Gene Expression</topic><topic>Immunoglobulins - immunology</topic><topic>Molecular Sequence Data</topic><topic>Peptides - analysis</topic><topic>Peptides - immunology</topic><topic>Rats</topic><topic>RNA Splicing</topic><topic>RNA, Messenger - analysis</topic><topic>RNA, Messenger - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Small, Stephen J.</creatorcontrib><creatorcontrib>Haines, Susan L.</creatorcontrib><creatorcontrib>Akeson, Richard A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuron (Cambridge, Mass.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Small, Stephen J.</au><au>Haines, Susan L.</au><au>Akeson, Richard A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing</atitle><jtitle>Neuron (Cambridge, Mass.)</jtitle><addtitle>Neuron</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>1</volume><issue>10</issue><spage>1007</spage><epage>1017</epage><pages>1007-1017</pages><issn>0896-6273</issn><eissn>1097-4199</eissn><abstract>The alternative splicing of a previously undiscovered 30 base exon confers a new level of polypeptide diversity on the N-CAM family of cell-surface glycoproteins. It results in the insertion of 10 amino acids into the fourth of five extracellular immunoglobulin-like folds. Each major size class of rat brain N-CAM mRNAs consists of members that contain or lack the exon. Furthermore, this splicing event is developmentally controlled: RNAs containing the inserted exon are expressed at extremely low levels (<3%) in embryonic brain but increase postnatally to 40%–45% of all N-CAM mRNAs in adult brain. Antibodies that recognize the alternative 10 amino acid segment react with a subset of N-CAM-expressing neurons in cultures of embryonic rat cells.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>2483093</pmid><doi>10.1016/0896-6273(88)90158-4</doi><tpages>11</tpages></addata></record> |
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| ispartof | Neuron (Cambridge, Mass.), 1988-12, Vol.1 (10), p.1007-1017 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Amino Acid Sequence Amino Acids - analysis Animals Base Sequence Brain - cytology Brain - metabolism Cell Adhesion Molecules, Neuronal - analysis Cell Adhesion Molecules, Neuronal - genetics Cell Adhesion Molecules, Neuronal - metabolism Cells, Cultured Chemical Phenomena Chemistry Epitopes - immunology Exons Gene Expression Immunoglobulins - immunology Molecular Sequence Data Peptides - analysis Peptides - immunology Rats RNA Splicing RNA, Messenger - analysis RNA, Messenger - genetics |
| title | Polypeptide variation in an N-CAM extracellular immunoglobulin-like fold is developmentally regulated through alternative splicing |
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