Lack of Predictable Site-Dependent Differences and Time-Dependent Changes in Postmortem Concentrations of Cocaine, Benzoylecgonine, and Cocaethylene in Humans
This study evaluated the stability of cocaine, benzoylecgonine, and cocaethylene in postmortem fluids in cases of cocaine-related death. Femoral and ventricular blood and cisternal cerebrospinal fluid were collected soon after death and again at the time of autopsy. In addition, iliac blood was coll...
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| Veröffentlicht in: | Journal of analytical toxicology 1997-01, Vol.21 (1), p.23-31 |
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| container_title | Journal of analytical toxicology |
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| creator | Logan, B.K. Smirnow, D. Gullberg, R.G. |
| description | This study evaluated the stability of cocaine, benzoylecgonine, and cocaethylene in postmortem fluids in cases of cocaine-related death. Femoral and ventricular blood and cisternal cerebrospinal fluid were collected soon after death and again at the time of autopsy. In addition, iliac blood was collected at autopsy. There were no consistent patterns of site-specific differences for any of the analytes, and the central compartment showed both higher and lower concentrations than the peripheral. There was no consistent pattern of direction or magnitude of change in the concentrations with respect to time for any of the analytes. This is consistent with anecdotal reports from other workers and is believed to be a result of competing processes of tissue release and chemical and enzymatic degradation of the analytes. Postmortem cocaine and metabolite concentrations in blood are not necessarily reflective of the perimortem concentrations and should not be the primary consideration in determining the cause of death in suspected cocaine-related deaths. |
| doi_str_mv | 10.1093/jat/21.1.23 |
| format | Article |
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Femoral and ventricular blood and cisternal cerebrospinal fluid were collected soon after death and again at the time of autopsy. In addition, iliac blood was collected at autopsy. There were no consistent patterns of site-specific differences for any of the analytes, and the central compartment showed both higher and lower concentrations than the peripheral. There was no consistent pattern of direction or magnitude of change in the concentrations with respect to time for any of the analytes. This is consistent with anecdotal reports from other workers and is believed to be a result of competing processes of tissue release and chemical and enzymatic degradation of the analytes. Postmortem cocaine and metabolite concentrations in blood are not necessarily reflective of the perimortem concentrations and should not be the primary consideration in determining the cause of death in suspected cocaine-related deaths.</description><identifier>ISSN: 0146-4760</identifier><identifier>EISSN: 1945-2403</identifier><identifier>DOI: 10.1093/jat/21.1.23</identifier><identifier>PMID: 9013288</identifier><identifier>CODEN: JATOD3</identifier><language>eng</language><publisher>Niles, IL: Oxford University Press</publisher><subject>Adult ; Autopsy ; Biological and medical sciences ; Blood ; Body Fluid Compartments ; Body Fluids - chemistry ; Cause of Death ; Cerebrospinal fluid ; Chromatography, High Pressure Liquid ; Cocaethylene ; Cocaine ; Cocaine - analogs & derivatives ; Cocaine - pharmacokinetics ; Dopamine Uptake Inhibitors - analysis ; Drug addictions ; Drug Stability ; Female ; Femur ; Forensic Medicine - methods ; Humans ; Male ; Medical sciences ; Metabolites ; Middle Aged ; Narcotics - pharmacokinetics ; Postmortem Changes ; Time Factors ; Tissue Distribution ; Toxicology ; Workers</subject><ispartof>Journal of analytical toxicology, 1997-01, Vol.21 (1), p.23-31</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-5296dc8f444d2721b095c1af0a21138811c0cbb02ecbfe26f505a648fc18d3153</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2535670$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9013288$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Logan, B.K.</creatorcontrib><creatorcontrib>Smirnow, D.</creatorcontrib><creatorcontrib>Gullberg, R.G.</creatorcontrib><title>Lack of Predictable Site-Dependent Differences and Time-Dependent Changes in Postmortem Concentrations of Cocaine, Benzoylecgonine, and Cocaethylene in Humans</title><title>Journal of analytical toxicology</title><addtitle>Journal of Analytical Toxicology</addtitle><addtitle>Journal of Analytical Toxicology</addtitle><description>This study evaluated the stability of cocaine, benzoylecgonine, and cocaethylene in postmortem fluids in cases of cocaine-related death. Femoral and ventricular blood and cisternal cerebrospinal fluid were collected soon after death and again at the time of autopsy. In addition, iliac blood was collected at autopsy. There were no consistent patterns of site-specific differences for any of the analytes, and the central compartment showed both higher and lower concentrations than the peripheral. There was no consistent pattern of direction or magnitude of change in the concentrations with respect to time for any of the analytes. This is consistent with anecdotal reports from other workers and is believed to be a result of competing processes of tissue release and chemical and enzymatic degradation of the analytes. Postmortem cocaine and metabolite concentrations in blood are not necessarily reflective of the perimortem concentrations and should not be the primary consideration in determining the cause of death in suspected cocaine-related deaths.</description><subject>Adult</subject><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Body Fluid Compartments</subject><subject>Body Fluids - chemistry</subject><subject>Cause of Death</subject><subject>Cerebrospinal fluid</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cocaethylene</subject><subject>Cocaine</subject><subject>Cocaine - analogs & derivatives</subject><subject>Cocaine - pharmacokinetics</subject><subject>Dopamine Uptake Inhibitors - analysis</subject><subject>Drug addictions</subject><subject>Drug Stability</subject><subject>Female</subject><subject>Femur</subject><subject>Forensic Medicine - methods</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Narcotics - pharmacokinetics</subject><subject>Postmortem Changes</subject><subject>Time Factors</subject><subject>Tissue Distribution</subject><subject>Toxicology</subject><subject>Workers</subject><issn>0146-4760</issn><issn>1945-2403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U-L1DAYBvAiyjqunjwLPYgI2tn8bdOjdl1HGHBkVxAvIU3f7Ga3TcYkBdcP42e13RlGT-4p8D4_niS8WfYcoyVGNT25VumE4CVeEvogW-Ca8YIwRB9mC4RZWbCqRI-zJzFeI4RLUdKj7KhGmBIhFtnvtdI3uTf5JkBndVJtD_m5TVCcwhZcBy7lp9YYCOA0xFy5Lr-ww79xc6Xc5RRZl298TIMPCYa88ZN3KahkvYvzDY3Xyjp4m78H98vf9qAvvbsbzKVzCulqGjuYq1bjoFx8mj0yqo_wbH8eZ1_PPlw0q2L9-eOn5t260EzQVHBSl50WhjHWkYrgFtVcY2WQIhhTITDWSLctIqBbA6Q0HHFVMmE0Fh3FnB5nr3a92-B_jBCTHGzU0PfKgR-jrIRAmBN8L8S8rrkQYoKv_w-nzbHpGYhO9M2O6uBjDGDkNthBhdsJ3Tk5bVgSLLEks36xLx7bAbqD3a90yl_ucxW16k1QTtt4YIRTXlbo70f8uL3nvmIHbUzw80BVuJFlRSsuV9--yy_ibMOaBslz-geGbMqi</recordid><startdate>19970101</startdate><enddate>19970101</enddate><creator>Logan, B.K.</creator><creator>Smirnow, D.</creator><creator>Gullberg, R.G.</creator><general>Oxford University Press</general><general>Preston</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19970101</creationdate><title>Lack of Predictable Site-Dependent Differences and Time-Dependent Changes in Postmortem Concentrations of Cocaine, Benzoylecgonine, and Cocaethylene in Humans</title><author>Logan, B.K. ; Smirnow, D. ; Gullberg, R.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-5296dc8f444d2721b095c1af0a21138811c0cbb02ecbfe26f505a648fc18d3153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Body Fluid Compartments</topic><topic>Body Fluids - chemistry</topic><topic>Cause of Death</topic><topic>Cerebrospinal fluid</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cocaethylene</topic><topic>Cocaine</topic><topic>Cocaine - analogs & derivatives</topic><topic>Cocaine - pharmacokinetics</topic><topic>Dopamine Uptake Inhibitors - analysis</topic><topic>Drug addictions</topic><topic>Drug Stability</topic><topic>Female</topic><topic>Femur</topic><topic>Forensic Medicine - methods</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Narcotics - pharmacokinetics</topic><topic>Postmortem Changes</topic><topic>Time Factors</topic><topic>Tissue Distribution</topic><topic>Toxicology</topic><topic>Workers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Logan, B.K.</creatorcontrib><creatorcontrib>Smirnow, D.</creatorcontrib><creatorcontrib>Gullberg, R.G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of analytical toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Logan, B.K.</au><au>Smirnow, D.</au><au>Gullberg, R.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of Predictable Site-Dependent Differences and Time-Dependent Changes in Postmortem Concentrations of Cocaine, Benzoylecgonine, and Cocaethylene in Humans</atitle><jtitle>Journal of analytical toxicology</jtitle><stitle>Journal of Analytical Toxicology</stitle><addtitle>Journal of Analytical Toxicology</addtitle><date>1997-01-01</date><risdate>1997</risdate><volume>21</volume><issue>1</issue><spage>23</spage><epage>31</epage><pages>23-31</pages><issn>0146-4760</issn><eissn>1945-2403</eissn><coden>JATOD3</coden><abstract>This study evaluated the stability of cocaine, benzoylecgonine, and cocaethylene in postmortem fluids in cases of cocaine-related death. Femoral and ventricular blood and cisternal cerebrospinal fluid were collected soon after death and again at the time of autopsy. In addition, iliac blood was collected at autopsy. There were no consistent patterns of site-specific differences for any of the analytes, and the central compartment showed both higher and lower concentrations than the peripheral. There was no consistent pattern of direction or magnitude of change in the concentrations with respect to time for any of the analytes. This is consistent with anecdotal reports from other workers and is believed to be a result of competing processes of tissue release and chemical and enzymatic degradation of the analytes. Postmortem cocaine and metabolite concentrations in blood are not necessarily reflective of the perimortem concentrations and should not be the primary consideration in determining the cause of death in suspected cocaine-related deaths.</abstract><cop>Niles, IL</cop><pub>Oxford University Press</pub><pmid>9013288</pmid><doi>10.1093/jat/21.1.23</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0146-4760 1945-2403 |
| language | eng |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adult Autopsy Biological and medical sciences Blood Body Fluid Compartments Body Fluids - chemistry Cause of Death Cerebrospinal fluid Chromatography, High Pressure Liquid Cocaethylene Cocaine Cocaine - analogs & derivatives Cocaine - pharmacokinetics Dopamine Uptake Inhibitors - analysis Drug addictions Drug Stability Female Femur Forensic Medicine - methods Humans Male Medical sciences Metabolites Middle Aged Narcotics - pharmacokinetics Postmortem Changes Time Factors Tissue Distribution Toxicology Workers |
| title | Lack of Predictable Site-Dependent Differences and Time-Dependent Changes in Postmortem Concentrations of Cocaine, Benzoylecgonine, and Cocaethylene in Humans |
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