ApoE-4 and age at onset of Alzheimer's disease : The NIMH genetics initiative

To explore the impact of apoE-4 on Alzheimer's disease (AD) and its age at onset. A genetic linkage study using affected relative pairs, predominantly siblings. Three academic medical centers ascertained subjects from memory disorder clinics, nursing homes, and the local community. 310 families...

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Veröffentlicht in:	Neurology 1997, Vol.48 (1), p.139-147
Hauptverfasser:	BLACKER, D, HAINES, J. L, ALBERT, M. S, TANZI, R, RODES, L, TERWEDOW, H, GO, R. C. P, HARRELL, L. E, PERRY, R. T, BASSETT, S. S, CHASE, G, MEYERS, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Age of Onset Aged Aging - psychology Alleles Alzheimer Disease - blood Alzheimer Disease - epidemiology Alzheimer Disease - genetics Apolipoprotein E4 Apolipoproteins E - analysis Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency Genetic Linkage Genotype Humans Lod Score Male Medical sciences Middle Aged Neurology Pedigree Reference Values
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