Whole gut washout for severe sepsis: Review of technique and preliminary results
Background. The purpose of this study was to determine the safety and feasibility of whole gut washout for severe sepsis in human beings. Methods. High-volume polyethylene glycol-3500 was administered to patients with severe sepsis. Body temperature, white blood cell count, and ventilatory indexes w...
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| Veröffentlicht in: | Surgery 1997, Vol.121 (1), p.89-94 |
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| creator | Alverdy, John Piano, Giancarlo |
| description | Background. The purpose of this study was to determine the safety and feasibility of whole gut washout for severe sepsis in human beings.
Methods. High-volume polyethylene glycol-3500 was administered to patients with severe sepsis. Body temperature, white blood cell count, and ventilatory indexes were recorded 24 hours before and 24 hours after whole gut washout.
Results. A significant decrease in febrile response was observed after gut washout with polyethylene glycol. Improvements in Pao
2, positive end-expiratory pressure, and peak airway pressure were observed. The washout was well tolerated in all but one patient.
Conclusions. High-volume whole gut washout for severe sepsis appears safe in critically ill patients and may offer some promise in reducing enterogenic inflammation after catabolic stress. |
| doi_str_mv | 10.1016/S0039-6060(97)90187-2 |
| format | Article |
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Methods. High-volume polyethylene glycol-3500 was administered to patients with severe sepsis. Body temperature, white blood cell count, and ventilatory indexes were recorded 24 hours before and 24 hours after whole gut washout.
Results. A significant decrease in febrile response was observed after gut washout with polyethylene glycol. Improvements in Pao
2, positive end-expiratory pressure, and peak airway pressure were observed. The washout was well tolerated in all but one patient.
Conclusions. High-volume whole gut washout for severe sepsis appears safe in critically ill patients and may offer some promise in reducing enterogenic inflammation after catabolic stress.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/S0039-6060(97)90187-2</identifier><identifier>PMID: 9001556</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Body Temperature ; Emergency and intensive care: infection, septic shock ; Feasibility Studies ; Female ; Humans ; Infection - blood ; Infection - physiopathology ; Infection - therapy ; Intensive care medicine ; Intestines ; Leukocyte Count ; Male ; Medical sciences ; Middle Aged ; Polyethylene Glycols - therapeutic use ; Respiratory Function Tests ; Therapeutic Irrigation ; Time Factors</subject><ispartof>Surgery, 1997, Vol.121 (1), p.89-94</ispartof><rights>1997</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-300ac5c91afd82128b926dfb68d73d5ffcc5636e3024c7a4c3fb9cc61bd410793</citedby><cites>FETCH-LOGICAL-c389t-300ac5c91afd82128b926dfb68d73d5ffcc5636e3024c7a4c3fb9cc61bd410793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0039-6060(97)90187-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2543922$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9001556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alverdy, John</creatorcontrib><creatorcontrib>Piano, Giancarlo</creatorcontrib><title>Whole gut washout for severe sepsis: Review of technique and preliminary results</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background. The purpose of this study was to determine the safety and feasibility of whole gut washout for severe sepsis in human beings.
Methods. High-volume polyethylene glycol-3500 was administered to patients with severe sepsis. Body temperature, white blood cell count, and ventilatory indexes were recorded 24 hours before and 24 hours after whole gut washout.
Results. A significant decrease in febrile response was observed after gut washout with polyethylene glycol. Improvements in Pao
2, positive end-expiratory pressure, and peak airway pressure were observed. The washout was well tolerated in all but one patient.
Conclusions. High-volume whole gut washout for severe sepsis appears safe in critically ill patients and may offer some promise in reducing enterogenic inflammation after catabolic stress.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Body Temperature</subject><subject>Emergency and intensive care: infection, septic shock</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Infection - blood</subject><subject>Infection - physiopathology</subject><subject>Infection - therapy</subject><subject>Intensive care medicine</subject><subject>Intestines</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polyethylene Glycols - therapeutic use</subject><subject>Respiratory Function Tests</subject><subject>Therapeutic Irrigation</subject><subject>Time Factors</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKtvCT6jkA0LlEBjbiT-4oKqiUKkSiA9xtBx7zBplk8VOWvHv8XZXe-3pPcwzM68eQs4ZvGXA5LvvAMI0EiRcGPXGANOq4U_IinWCN0pI9pSsjshzclrKHwAwLdMn5MQAsK6TK_L113oakP5eZnrvynqqGadMC95hxhrbksp7-g3vEt7TKdIZ_XpMfxekbgx0m3FImzS6_I9mLMswlxfkWXRDwZeHPCM_rz_-uPrc3H75dHN1edt4oc3cCADnO2-Yi0FzxnVvuAyxlzooEboYve-kkCiAt1651ovYG-8l60PLQBlxRl7v727zVOuU2W5S8TgMbsRpKVZpZYwGXcFuD_o8lZIx2m1Om9rYMrA7k_bBpN1pskbZB5OW173zw4Ol32A4bh3U1fmrw9wV74aY3ehTOWK8a4XhuzMf9hhWGdVitsUnHD2GlNHPNkzpkSL_AcInkFk</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Alverdy, John</creator><creator>Piano, Giancarlo</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>Whole gut washout for severe sepsis: Review of technique and preliminary results</title><author>Alverdy, John ; Piano, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-300ac5c91afd82128b926dfb68d73d5ffcc5636e3024c7a4c3fb9cc61bd410793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Body Temperature</topic><topic>Emergency and intensive care: infection, septic shock</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Infection - blood</topic><topic>Infection - physiopathology</topic><topic>Infection - therapy</topic><topic>Intensive care medicine</topic><topic>Intestines</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polyethylene Glycols - therapeutic use</topic><topic>Respiratory Function Tests</topic><topic>Therapeutic Irrigation</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alverdy, John</creatorcontrib><creatorcontrib>Piano, Giancarlo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alverdy, John</au><au>Piano, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole gut washout for severe sepsis: Review of technique and preliminary results</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>1997</date><risdate>1997</risdate><volume>121</volume><issue>1</issue><spage>89</spage><epage>94</epage><pages>89-94</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background. The purpose of this study was to determine the safety and feasibility of whole gut washout for severe sepsis in human beings.
Methods. High-volume polyethylene glycol-3500 was administered to patients with severe sepsis. Body temperature, white blood cell count, and ventilatory indexes were recorded 24 hours before and 24 hours after whole gut washout.
Results. A significant decrease in febrile response was observed after gut washout with polyethylene glycol. Improvements in Pao
2, positive end-expiratory pressure, and peak airway pressure were observed. The washout was well tolerated in all but one patient.
Conclusions. High-volume whole gut washout for severe sepsis appears safe in critically ill patients and may offer some promise in reducing enterogenic inflammation after catabolic stress.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>9001556</pmid><doi>10.1016/S0039-6060(97)90187-2</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Body Temperature Emergency and intensive care: infection, septic shock Feasibility Studies Female Humans Infection - blood Infection - physiopathology Infection - therapy Intensive care medicine Intestines Leukocyte Count Male Medical sciences Middle Aged Polyethylene Glycols - therapeutic use Respiratory Function Tests Therapeutic Irrigation Time Factors |
| title | Whole gut washout for severe sepsis: Review of technique and preliminary results |
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