Expression of the Zn finger gene, EVI-1, in acute promyelocytic leukemia

The EVI-1 gene encodes a Zn finger, DNA binding protein previously detected in some acute myelogenous leukemias (AML) and myelodysplasias (MDS), but not in normal marrow or cord blood cells. Experimental studies suggest EVI-1 blocks cellular differentiation by binding to GATA-1 or other specific DNA...

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Veröffentlicht in:	Leukemia 1997-02, Vol.11 (2), p.212-220
Hauptverfasser:	XI, Z. F, RUSSELL, M, WOODWARD, S, THOMPSON, F, WAGNER, L, TAETLE, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetamides - pharmacology Acute myeloid leukemia Acute promyeloid leukemia Biological activity Biological and medical sciences Blood cells Cell culture Cell differentiation Cell Differentiation - drug effects Continuous culture Cord blood Deoxyribonucleic acid Differentiation (biology) DNA DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Fusion protein Gene expression Gene Expression Regulation, Leukemic - drug effects Gene sequencing Hematologic and hematopoietic diseases Histiocytic lymphoma HL-60 Cells Humans Isotretinoin - pharmacology Leukemia Leukemia, Promyelocytic, Acute - drug therapy Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma Lymphoma, Large B-Cell, Diffuse - pathology MDS1 and EVI1 Complex Locus Protein Medical sciences Myelodysplastic syndrome Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Nucleotide sequence Oncogene Proteins, Fusion - biosynthesis Oncogene Proteins, Fusion - genetics Pathogenesis Promyeloid leukemia Proto-Oncogenes Retinoic acid Ribonucleic acid RNA Transcription Factors Tretinoin - pharmacology Tretinoin - therapeutic use Tumor Cells, Cultured Zinc Zinc Fingers
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