Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci. Irreversible inhibition by UDP-chloroacetol

UDP-glucuronic acid is used by many pathogenic bacteria in the construction of an antiphagocytic capsule that is required for virulence. The enzyme UDP-glucose dehydrogenase catalyzes the NAD+-dependent 2-fold oxidation of UDP-glucose and provides a source of the acid. In the present study the recom...

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Veröffentlicht in:	The Journal of biological chemistry 1997-02, Vol.272 (6), p.3416-3422
Hauptverfasser:	Campbell, R E, Sala, R F, van de Rijn, I, Tanner, M E
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Gel Enzyme Inhibitors - pharmacology Kinetics Models, Chemical NAD - metabolism Spectrophotometry, Ultraviolet Streptococcus pyogenes UDPglucose 4-Epimerase - antagonists & inhibitors Uridine Diphosphate - analogs & derivatives Uridine Diphosphate - pharmacology Uridine Diphosphate Glucose Dehydrogenase - metabolism Uridine Diphosphate Xylose - metabolism
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