Retinal pigment epithelial cells from dystrophic rats form normal tight junctions in vitro

In the genetically defective Royal College of Surgeons (RCS) rat model for retinal degeneration, a breakdown occurs in the retinal pigment epithelial (RPE) cell tight junctions just as the photoreceptors begin to degenerate. These experiments sought to determine the impact of the RPE genetic defect...

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Veröffentlicht in:	Investigative ophthalmology & visual science 1997-01, Vol.38 (1), p.188-195
Hauptverfasser:	Chang, CW, Defoe, DM, Caldwell, RB
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Biological and medical sciences Blood-Retinal Barrier Cell Culture Techniques Cell Membrane Permeability Culture Media Culture Media, Conditioned Fluorescent Antibody Technique, Indirect L-Lactate Dehydrogenase - metabolism Medical sciences Membrane Potentials Membrane Proteins - metabolism Ophthalmology Phosphoproteins - metabolism Pigment Epithelium of Eye - metabolism Pigment Epithelium of Eye - pathology Rats Rats, Mutant Strains Retinal Degeneration - genetics Retinal Degeneration - metabolism Retinal Degeneration - pathology Retinopathies Tight Junctions - metabolism Tight Junctions - pathology Zonula Occludens-1 Protein
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