Peripheral NMDA receptors contribute to activation of nociceptors: a c-fos expression study in rats

By using immunocytochemical techniques, we demonstrated that: (1) unilateral injection of N-methyl- d-aspartate (NMDA; 10, 20, 50 μmol) into the plantar aspect of hindpaw of the normal waked rats elicited a dose-dependent increase of c-fos expression in the superficial laminae on the side of the spi...

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Veröffentlicht in:	Neuroscience letters 1997-01, Vol.221 (2), p.101-104
Hauptverfasser:	Wang, H, Liu, R.J, Zhang, R.X, Qiao, J.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences c-fos Expression Dizocilpine Maleate - administration & dosage Dizocilpine Maleate - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Agonists - administration & dosage Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Female Fundamental and applied biological sciences. Psychology Male MK-801 N-Methyl- d-aspartate N-Methylaspartate - administration & dosage N-Methylaspartate - pharmacology Nociceptors - drug effects Nociceptors - physiology Peripheral N-methyl- d-aspartate receptor Peripheral nociception Presynaptic Terminals - drug effects Presynaptic Terminals - metabolism Proto-Oncogene Proteins c-fos - biosynthesis Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - drug effects Receptors, N-Methyl-D-Aspartate - physiology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal Cord - drug effects Spinal Cord - metabolism Vertebrates: nervous system and sense organs
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