Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes

The human and rat genes for a fifth muscarinic receptor have been cloned and expressed in mammalian cells. The 532 amino acid human protein has 89% sequence identity to the 531 amino acid rat protein and is most closely related to the m3 receptor. Both proteins are encoded by single exons. The recep...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 1988-07, Vol.1 (5), p.403-410
Hauptverfasser:	Bonner, Tom I., Young, Alice C., Bran, Mark R., Buckley, Noel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Binding, Competitive Cell Line Cloning, Molecular Gene Expression Genetic Vectors Humans Inositol Phosphates - metabolism Kinetics Molecular Sequence Data Parasympatholytics - pharmacology Pirenzepine - analogs & derivatives Pirenzepine - pharmacology Rats Receptors, Muscarinic - genetics Receptors, Muscarinic - metabolism Restriction Mapping Sequence Homology, Nucleic Acid Transfection
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