Genetic analysis of renin gene expression in the central nervous system of spontaneously hypertensive rats
Renin expression in the central nervous system in spontaneously hypertensive rats (SHR) has been reported to be higher than that in age-matched Wistar–Kyoto (WKY) rats. In the present study, we examined the mechanisms of enhancement of renin mRNA concentration in the brainstem of SHR using F 2 hybri...
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| Veröffentlicht in: | Neuroscience letters 1997-01, Vol.221 (2), p.133-136 |
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| creator | Shimoike, Hitoshi Iwai, Naoharu Kinoshita, Masahiko |
| description | Renin expression in the central nervous system in spontaneously hypertensive rats (SHR) has been reported to be higher than that in age-matched Wistar–Kyoto (WKY) rats. In the present study, we examined the mechanisms of enhancement of renin mRNA concentration in the brainstem of SHR using F
2 hybrid rats derived from cross-breeding SHR with WKY. The SHR allele of the renin gene was significantly associated with higher brain renin mRNA concentration in both 10- and 24-week-old F
2 populations. However, neither the genotype of the renin gene nor the brain renin mRNA concentration was associated with blood pressure or urinary volume. Thus, the higher renin mRNA concentration in the brainstem of SHR was indicated to be genetically determined by the genotype of the renin gene. Further study is required to clarify the pathophysiological meaning of this increased renin expression in the brain of SHR. |
| doi_str_mv | 10.1016/S0304-3940(96)13295-X |
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2 hybrid rats derived from cross-breeding SHR with WKY. The SHR allele of the renin gene was significantly associated with higher brain renin mRNA concentration in both 10- and 24-week-old F
2 populations. However, neither the genotype of the renin gene nor the brain renin mRNA concentration was associated with blood pressure or urinary volume. Thus, the higher renin mRNA concentration in the brainstem of SHR was indicated to be genetically determined by the genotype of the renin gene. Further study is required to clarify the pathophysiological meaning of this increased renin expression in the brain of SHR.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(96)13295-X</identifier><identifier>PMID: 9121682</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aldosterone - blood ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - drug effects ; Body Weight ; Brain Stem - metabolism ; Brainstem ; Cardiology. Vascular system ; Central Nervous System - metabolism ; DNA - genetics ; DNA - isolation & purification ; Experimental diseases ; Female ; Gene Deletion ; Genes ; Genotype ; Hypertension - genetics ; Hypertension - metabolism ; Hypertension - urine ; Liver - chemistry ; Male ; Medical sciences ; Oligonucleotide Probes ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Renin ; Renin - biosynthesis ; Renin - blood ; Renin - genetics ; Renin-angiotensin system ; RNA, Messenger - biosynthesis ; Spontaneously hypertensive rats</subject><ispartof>Neuroscience letters, 1997-01, Vol.221 (2), p.133-136</ispartof><rights>1997 Elsevier Science Ireland Ltd</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-dab9cbf7c8f113e5eb6e237dcc2c3f9d4402f1aff8c47b5f302f878d46cfb2ac3</citedby><cites>FETCH-LOGICAL-c389t-dab9cbf7c8f113e5eb6e237dcc2c3f9d4402f1aff8c47b5f302f878d46cfb2ac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0304-3940(96)13295-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2558650$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9121682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimoike, Hitoshi</creatorcontrib><creatorcontrib>Iwai, Naoharu</creatorcontrib><creatorcontrib>Kinoshita, Masahiko</creatorcontrib><title>Genetic analysis of renin gene expression in the central nervous system of spontaneously hypertensive rats</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Renin expression in the central nervous system in spontaneously hypertensive rats (SHR) has been reported to be higher than that in age-matched Wistar–Kyoto (WKY) rats. In the present study, we examined the mechanisms of enhancement of renin mRNA concentration in the brainstem of SHR using F
2 hybrid rats derived from cross-breeding SHR with WKY. The SHR allele of the renin gene was significantly associated with higher brain renin mRNA concentration in both 10- and 24-week-old F
2 populations. However, neither the genotype of the renin gene nor the brain renin mRNA concentration was associated with blood pressure or urinary volume. Thus, the higher renin mRNA concentration in the brainstem of SHR was indicated to be genetically determined by the genotype of the renin gene. Further study is required to clarify the pathophysiological meaning of this increased renin expression in the brain of SHR.</description><subject>Aldosterone - blood</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - drug effects</subject><subject>Body Weight</subject><subject>Brain Stem - metabolism</subject><subject>Brainstem</subject><subject>Cardiology. Vascular system</subject><subject>Central Nervous System - metabolism</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>Experimental diseases</subject><subject>Female</subject><subject>Gene Deletion</subject><subject>Genes</subject><subject>Genotype</subject><subject>Hypertension - genetics</subject><subject>Hypertension - metabolism</subject><subject>Hypertension - urine</subject><subject>Liver - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Oligonucleotide Probes</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Renin</subject><subject>Renin - biosynthesis</subject><subject>Renin - blood</subject><subject>Renin - genetics</subject><subject>Renin-angiotensin system</subject><subject>RNA, Messenger - biosynthesis</subject><subject>Spontaneously hypertensive rats</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2LFDEQhoMo67j6ExZyENFDaz46nfRJZNFVWPCgwt5COl1xs_Sk21RmsP-9mZ1hrp5C6n0qVXkIueLsPWe8-_CDSdY2sm_Z2757x6XoVXP3hGy40aLRvRZPyeaMPCcvEB8YY4qr9oJc9FzwzogNebiBBCV66pKbVoxI50AzpJjo75pQ-LtkQIxzorVU7oF6SCW7iSbI-3mHFFcssD204TKn4hLU6rTS-3WBXCBh3APNruBL8iy4CeHV6bwkv758_nn9tbn9fvPt-tNt46XpSzO6ofdD0N4EziUoGDoQUo_eCy9DP7YtE4G7EIxv9aCCrFejzdh2PgzCeXlJ3hzfXfL8ZwdY7Daih2k6rma10fX7squgOoI-z4gZgl1y3Lq8Ws7swbF9dGwPAm3f2UfH9q72XZ0G7IYtjOeuk9Savz7lDr2bQnbJRzxjQinTKVaxj0cMqox9hGzRR0gexpjBFzvO8T-L_ANxM5x2</recordid><startdate>19970117</startdate><enddate>19970117</enddate><creator>Shimoike, Hitoshi</creator><creator>Iwai, Naoharu</creator><creator>Kinoshita, Masahiko</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19970117</creationdate><title>Genetic analysis of renin gene expression in the central nervous system of spontaneously hypertensive rats</title><author>Shimoike, Hitoshi ; Iwai, Naoharu ; Kinoshita, Masahiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-dab9cbf7c8f113e5eb6e237dcc2c3f9d4402f1aff8c47b5f302f878d46cfb2ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Aldosterone - blood</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - drug effects</topic><topic>Body Weight</topic><topic>Brain Stem - metabolism</topic><topic>Brainstem</topic><topic>Cardiology. Vascular system</topic><topic>Central Nervous System - metabolism</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>Experimental diseases</topic><topic>Female</topic><topic>Gene Deletion</topic><topic>Genes</topic><topic>Genotype</topic><topic>Hypertension - genetics</topic><topic>Hypertension - metabolism</topic><topic>Hypertension - urine</topic><topic>Liver - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Oligonucleotide Probes</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Renin</topic><topic>Renin - biosynthesis</topic><topic>Renin - blood</topic><topic>Renin - genetics</topic><topic>Renin-angiotensin system</topic><topic>RNA, Messenger - biosynthesis</topic><topic>Spontaneously hypertensive rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shimoike, Hitoshi</creatorcontrib><creatorcontrib>Iwai, Naoharu</creatorcontrib><creatorcontrib>Kinoshita, Masahiko</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimoike, Hitoshi</au><au>Iwai, Naoharu</au><au>Kinoshita, Masahiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic analysis of renin gene expression in the central nervous system of spontaneously hypertensive rats</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1997-01-17</date><risdate>1997</risdate><volume>221</volume><issue>2</issue><spage>133</spage><epage>136</epage><pages>133-136</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Renin expression in the central nervous system in spontaneously hypertensive rats (SHR) has been reported to be higher than that in age-matched Wistar–Kyoto (WKY) rats. In the present study, we examined the mechanisms of enhancement of renin mRNA concentration in the brainstem of SHR using F
2 hybrid rats derived from cross-breeding SHR with WKY. The SHR allele of the renin gene was significantly associated with higher brain renin mRNA concentration in both 10- and 24-week-old F
2 populations. However, neither the genotype of the renin gene nor the brain renin mRNA concentration was associated with blood pressure or urinary volume. Thus, the higher renin mRNA concentration in the brainstem of SHR was indicated to be genetically determined by the genotype of the renin gene. Further study is required to clarify the pathophysiological meaning of this increased renin expression in the brain of SHR.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9121682</pmid><doi>10.1016/S0304-3940(96)13295-X</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1997-01, Vol.221 (2), p.133-136 |
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| language | eng |
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| subjects | Aldosterone - blood Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Body Weight Brain Stem - metabolism Brainstem Cardiology. Vascular system Central Nervous System - metabolism DNA - genetics DNA - isolation & purification Experimental diseases Female Gene Deletion Genes Genotype Hypertension - genetics Hypertension - metabolism Hypertension - urine Liver - chemistry Male Medical sciences Oligonucleotide Probes Rats Rats, Inbred SHR Rats, Inbred WKY Renin Renin - biosynthesis Renin - blood Renin - genetics Renin-angiotensin system RNA, Messenger - biosynthesis Spontaneously hypertensive rats |
| title | Genetic analysis of renin gene expression in the central nervous system of spontaneously hypertensive rats |
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