HER‐2/neu Signal Transduction in Human Breast and Ovarian Cancer

The HER‐2/neu proto‐oncogene encodes a 185 kDa transmembrane receptor tyrosine kinase with significant sequence homology to other members of the class I receptor tyrosine kinase family. The HER‐2/neu gene is amplified and/or overexpressed in 25%‐30% of human breast and ovarian cancers, and overexpre...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 1997-01, Vol.15 (1), p.1-8
Hauptverfasser:	Reese, David M., Slamon, Dennis J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast cancer Breast Neoplasms - chemistry Breast Neoplasms - genetics Epidermal growth factor erbB receptors Female Heregulin HER‐2/neu Humans Ovarian cancer Ovarian Neoplasms - chemistry Ovarian Neoplasms - genetics Receptor, ErbB-2 - physiology Signal Transduction
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