Wild-Type, but Not Mutant-Type, p53 Enhances Nuclear Accumulation of the NS3 Protein of Hepatitis C Virus

By using vaccinia virus-T7 hybrid expression system, subcellular localization of the NS3 protein of hepatitis C virus was studied. Full-size NS3 (NS3F) and a carboxy-terminally truncated form (NS3ΔC) were localized in the cytoplasm and the nucleus when expressed alone. However, NS3F and NS3ΔC, but n...

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Veröffentlicht in:	Biochemical and biophysical research communications 1997-01, Vol.230 (2), p.431-436
Hauptverfasser:	Ishido, Satoshi, Muramatsu, Sanshiro, Fujita, Tsunenori, Iwanaga, Yasuhiro, Tong, Wen-Yan, Katayama, Yuko, Itoh, Masae, Hotta, Hak
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Nucleus - metabolism DNA Primers Fluorescent Antibody Technique, Indirect Genetic Vectors HeLa Cells Hepacivirus - physiology Humans Polymerase Chain Reaction Recombinant Proteins - analysis Recombinant Proteins - biosynthesis Recombinant Proteins - metabolism Sequence Deletion Serine Endopeptidases - biosynthesis Transfection Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Vaccinia virus Viral Nonstructural Proteins - analysis Viral Nonstructural Proteins - biosynthesis
Online-Zugang:	Volltext
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