Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein

The agent responsible for transmissible spongiform encephalopathies (TSEs) is thought to be a malfolded, protease-resistant version (PrPres) of the normal cellular prion protein (PrP). The interspecies transmission of bovine spongiform encephalopathy (BSE) to mice was studied. Although all of the mi...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1997-01, Vol.275 (5298), p.402-405
Hauptverfasser:	Lasmezas, C.I. (Commissariat a l'Energie Atomique, Fontenay-aux-Roses, France.), Deslys, J.P, Robain, I, Jaegly, A, Beringue, V, Peyrin, J.M, Fournier, J.G, Hauw, J.J, Rossier, J, Dormont, D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy Animals Apoptosis Astrocytes - pathology Biological and medical sciences Bovine spongiform encephalopathy Brain Brain - pathology Brain Chemistry Cattle Cerebral hemispheres CEREBRO Creutzfeldt Jakob syndrome Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease transmission ENCEFALOPATIA ESPONGIFORME ENCEPHALE ENCEPHALOPATHIE SPONGIFORME Encephalopathy, Bovine Spongiform - metabolism Encephalopathy, Bovine Spongiform - pathology Encephalopathy, Bovine Spongiform - transmission Endopeptidases - metabolism Inoculum Lesions Medical sciences Mice Mice, Inbred C57BL Nerve Tissue Proteins - analysis Nervous system diseases Neurology Pathology Phenotype Physiological aspects Prions Prions (Proteins) Prions - analysis PROTEINAS PROTEINE Proteins Purkinje cells Purkinje Cells - pathology RATON Rodents Serial Passage SINTOMAS SOURIS SYMPTOME Time Factors TRANSMISION DE ENFERMEDADES TRANSMISSION DES MALADIES Vacuoles - pathology
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