Obese Patients with Sleep Apnea Syndrome Treated by Progesterone
Two obese patients with sleep apnea syndrome were administered chlormadinone acetate (CMA), a synthetic progesterone, known as a potent respiratory stimulant to augment load compensation response as well as CO2 chemosensitivity. Before CMA administration, both cases showed normal chemosensitivity of...
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| Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1988, Vol.156(Suppl), pp.151-157 |
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| container_title | The Tohoku Journal of Experimental Medicine |
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| creator | KIMURA, HIROSHI TATSUMI, KOUICHIRO KUNITOMO, FUMIO OKITA, SHINYA TOJIMA, HIROKAZU KOUCHIYAMA, SHIRO MASUYAMA, SHIGERU SHINOZAKI, TOSHIHIDE MIKAMI, MAKOTO WATANABE, SHOHEI ISHIKAWA, YOU HONDA, YOSHIYUKI KURIYAMA, TAKAYUKI |
| description | Two obese patients with sleep apnea syndrome were administered chlormadinone acetate (CMA), a synthetic progesterone, known as a potent respiratory stimulant to augment load compensation response as well as CO2 chemosensitivity. Before CMA administration, both cases showed normal chemosensitivity of hypoxic and hypercapnic ventilatory responses (HVR and HCVR) at daytime, although marked oxygen desaturation with sleep apnea was observed. During CMA administration for 7 days, HVR, HCVR and occlusion pressure response to flow-resistive loading were altogether augmented. In one case obstructive sleep apnea (OSA) was altered to obstructive hypopnea, and in the other case central apnea disappeared completely, resulting in remarkable improvement of oxygen desaturation at sleep and daytime somnolence in both cases. We conclude that CMA might be useful in the treatment of sleep apnea syndrome. |
| doi_str_mv | 10.1620/tjem.156.Suppl_151 |
| format | Article |
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Before CMA administration, both cases showed normal chemosensitivity of hypoxic and hypercapnic ventilatory responses (HVR and HCVR) at daytime, although marked oxygen desaturation with sleep apnea was observed. During CMA administration for 7 days, HVR, HCVR and occlusion pressure response to flow-resistive loading were altogether augmented. In one case obstructive sleep apnea (OSA) was altered to obstructive hypopnea, and in the other case central apnea disappeared completely, resulting in remarkable improvement of oxygen desaturation at sleep and daytime somnolence in both cases. We conclude that CMA might be useful in the treatment of sleep apnea syndrome.</description><identifier>ISSN: 0040-8727</identifier><identifier>EISSN: 1349-3329</identifier><identifier>DOI: 10.1620/tjem.156.Suppl_151</identifier><identifier>PMID: 2479120</identifier><language>eng</language><publisher>Japan: Tohoku University Medical Press</publisher><subject>Adolescent ; Blood Gas Analysis ; Chlormadinone Acetate - therapeutic use ; Electrocardiography ; Electroencephalography ; Electromyography ; Electrooculography ; Humans ; load compensation ; Male ; Middle Aged ; Obesity - complications ; obstructive sleep apnea ; progesterone ; sleep apnea syndrome ; Sleep Apnea Syndromes - blood ; Sleep Apnea Syndromes - drug therapy ; Sleep Apnea Syndromes - etiology</subject><ispartof>The Tohoku Journal of Experimental Medicine, 1988, Vol.156(Suppl), pp.151-157</ispartof><rights>Tohoku University Medical Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4431-9e40d7e910ccc25940055647ebaa7dde46b5d5163276e80d0cd82bfc08b74e893</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1876,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2479120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KIMURA, HIROSHI</creatorcontrib><creatorcontrib>TATSUMI, KOUICHIRO</creatorcontrib><creatorcontrib>KUNITOMO, FUMIO</creatorcontrib><creatorcontrib>OKITA, SHINYA</creatorcontrib><creatorcontrib>TOJIMA, HIROKAZU</creatorcontrib><creatorcontrib>KOUCHIYAMA, SHIRO</creatorcontrib><creatorcontrib>MASUYAMA, SHIGERU</creatorcontrib><creatorcontrib>SHINOZAKI, TOSHIHIDE</creatorcontrib><creatorcontrib>MIKAMI, MAKOTO</creatorcontrib><creatorcontrib>WATANABE, SHOHEI</creatorcontrib><creatorcontrib>ISHIKAWA, YOU</creatorcontrib><creatorcontrib>HONDA, YOSHIYUKI</creatorcontrib><creatorcontrib>KURIYAMA, TAKAYUKI</creatorcontrib><title>Obese Patients with Sleep Apnea Syndrome Treated by Progesterone</title><title>The Tohoku Journal of Experimental Medicine</title><addtitle>Tohoku J. Exp. Med.</addtitle><description>Two obese patients with sleep apnea syndrome were administered chlormadinone acetate (CMA), a synthetic progesterone, known as a potent respiratory stimulant to augment load compensation response as well as CO2 chemosensitivity. Before CMA administration, both cases showed normal chemosensitivity of hypoxic and hypercapnic ventilatory responses (HVR and HCVR) at daytime, although marked oxygen desaturation with sleep apnea was observed. During CMA administration for 7 days, HVR, HCVR and occlusion pressure response to flow-resistive loading were altogether augmented. In one case obstructive sleep apnea (OSA) was altered to obstructive hypopnea, and in the other case central apnea disappeared completely, resulting in remarkable improvement of oxygen desaturation at sleep and daytime somnolence in both cases. We conclude that CMA might be useful in the treatment of sleep apnea syndrome.</description><subject>Adolescent</subject><subject>Blood Gas Analysis</subject><subject>Chlormadinone Acetate - therapeutic use</subject><subject>Electrocardiography</subject><subject>Electroencephalography</subject><subject>Electromyography</subject><subject>Electrooculography</subject><subject>Humans</subject><subject>load compensation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>obstructive sleep apnea</subject><subject>progesterone</subject><subject>sleep apnea syndrome</subject><subject>Sleep Apnea Syndromes - blood</subject><subject>Sleep Apnea Syndromes - drug therapy</subject><subject>Sleep Apnea Syndromes - etiology</subject><issn>0040-8727</issn><issn>1349-3329</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtrwkAUhYfSYq3tHygUsuou9s4jmWRXKX2BVEG7HiYzV43k1ZmE4r9vrCKu7uKc8134CLmnMKYxg6d2i-WYRvF40TVNoWhEL8iQcpGGnLP0kgwBBISJZPKa3Hi_BeACZDwgAyZkShkMyfMsQ4_BXLc5Vq0PfvN2EywKxCaYNBXqYLGrrKtLDJYOdYs2yHbB3NVr9C26usJbcrXShce74x2R77fX5ctHOJ29f75MpqERgtMwRQFWYkrBGMOiVABEUSwkZlpLa1HEWWQjGnMmY0zAgrEJy1YGkkwKTFI-Io8HbuPqn67_rsrcGywKXWHdeSUTmTApeF9kh6JxtfcOV6pxeandTlFQe21qr62XFauTtn70cKR3WYn2NDl66vOvQ771rV7jKdeuzU2B_0ia9uxz7NmDU9FstFNY8T8YN4dJ</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>KIMURA, HIROSHI</creator><creator>TATSUMI, KOUICHIRO</creator><creator>KUNITOMO, FUMIO</creator><creator>OKITA, SHINYA</creator><creator>TOJIMA, HIROKAZU</creator><creator>KOUCHIYAMA, SHIRO</creator><creator>MASUYAMA, SHIGERU</creator><creator>SHINOZAKI, TOSHIHIDE</creator><creator>MIKAMI, MAKOTO</creator><creator>WATANABE, SHOHEI</creator><creator>ISHIKAWA, YOU</creator><creator>HONDA, YOSHIYUKI</creator><creator>KURIYAMA, TAKAYUKI</creator><general>Tohoku University Medical Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Obese Patients with Sleep Apnea Syndrome Treated by Progesterone</title><author>KIMURA, HIROSHI ; TATSUMI, KOUICHIRO ; KUNITOMO, FUMIO ; OKITA, SHINYA ; TOJIMA, HIROKAZU ; KOUCHIYAMA, SHIRO ; MASUYAMA, SHIGERU ; SHINOZAKI, TOSHIHIDE ; MIKAMI, MAKOTO ; WATANABE, SHOHEI ; ISHIKAWA, YOU ; HONDA, YOSHIYUKI ; KURIYAMA, TAKAYUKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4431-9e40d7e910ccc25940055647ebaa7dde46b5d5163276e80d0cd82bfc08b74e893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Blood Gas Analysis</topic><topic>Chlormadinone Acetate - therapeutic use</topic><topic>Electrocardiography</topic><topic>Electroencephalography</topic><topic>Electromyography</topic><topic>Electrooculography</topic><topic>Humans</topic><topic>load compensation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>obstructive sleep apnea</topic><topic>progesterone</topic><topic>sleep apnea syndrome</topic><topic>Sleep Apnea Syndromes - blood</topic><topic>Sleep Apnea Syndromes - drug therapy</topic><topic>Sleep Apnea Syndromes - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KIMURA, HIROSHI</creatorcontrib><creatorcontrib>TATSUMI, KOUICHIRO</creatorcontrib><creatorcontrib>KUNITOMO, FUMIO</creatorcontrib><creatorcontrib>OKITA, SHINYA</creatorcontrib><creatorcontrib>TOJIMA, HIROKAZU</creatorcontrib><creatorcontrib>KOUCHIYAMA, SHIRO</creatorcontrib><creatorcontrib>MASUYAMA, SHIGERU</creatorcontrib><creatorcontrib>SHINOZAKI, TOSHIHIDE</creatorcontrib><creatorcontrib>MIKAMI, MAKOTO</creatorcontrib><creatorcontrib>WATANABE, SHOHEI</creatorcontrib><creatorcontrib>ISHIKAWA, YOU</creatorcontrib><creatorcontrib>HONDA, YOSHIYUKI</creatorcontrib><creatorcontrib>KURIYAMA, TAKAYUKI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Tohoku Journal of Experimental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KIMURA, HIROSHI</au><au>TATSUMI, KOUICHIRO</au><au>KUNITOMO, FUMIO</au><au>OKITA, SHINYA</au><au>TOJIMA, HIROKAZU</au><au>KOUCHIYAMA, SHIRO</au><au>MASUYAMA, SHIGERU</au><au>SHINOZAKI, TOSHIHIDE</au><au>MIKAMI, MAKOTO</au><au>WATANABE, SHOHEI</au><au>ISHIKAWA, YOU</au><au>HONDA, YOSHIYUKI</au><au>KURIYAMA, TAKAYUKI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obese Patients with Sleep Apnea Syndrome Treated by Progesterone</atitle><jtitle>The Tohoku Journal of Experimental Medicine</jtitle><addtitle>Tohoku J. 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| ispartof | The Tohoku Journal of Experimental Medicine, 1988, Vol.156(Suppl), pp.151-157 |
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| source | J-STAGE Free; MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Blood Gas Analysis Chlormadinone Acetate - therapeutic use Electrocardiography Electroencephalography Electromyography Electrooculography Humans load compensation Male Middle Aged Obesity - complications obstructive sleep apnea progesterone sleep apnea syndrome Sleep Apnea Syndromes - blood Sleep Apnea Syndromes - drug therapy Sleep Apnea Syndromes - etiology |
| title | Obese Patients with Sleep Apnea Syndrome Treated by Progesterone |
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