Cerebrospinal Fluid Interleukin-6 in Progressive Neuro-Behçet's Syndrome
Central nervous system (CNS) involvement in Behçet's disease, usually called neuro-Behçet's syndrome (NB), is one of the most serious complications of the disease. The present study examined cerebrospinal fluid (CSF) interleukin-6 (IL-6) activity in patients with NB to explore its relevanc...
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| Veröffentlicht in: | Clinical immunology and immunopathology 1997-01, Vol.82 (1), p.12-17 |
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| container_title | Clinical immunology and immunopathology |
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| creator | Hirohata, Shunsei Isshi, Kunio Oguchi, Hiroko Ohse, Toru Haraoka, Hitomi Takeuchi, Akiteru Hashimoto, Takashi |
| description | Central nervous system (CNS) involvement in Behçet's disease, usually called neuro-Behçet's syndrome (NB), is one of the most serious complications of the disease. The present study examined cerebrospinal fluid (CSF) interleukin-6 (IL-6) activity in patients with NB to explore its relevance to the progressive CNS disease. Paired CSF and serum specimens were obtained from 11 patients who were diagnosed as having progressive NB based on careful clinical observation and from 11 patients with active Behçet's disease but lacking progressive CNS disease. IL-6 levels in the CSF and sera were determined using IL-6-dependent murine hybridoma MH60.BSF2 cells. All 11 patients with progressive NB showed marked elevation of CSF IL-6 activity [0.18–3.90 U/ml, 1.19 ± 1.18 (mean ± SD), normal range, |
| doi_str_mv | 10.1006/clin.1996.4268 |
| format | Article |
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The present study examined cerebrospinal fluid (CSF) interleukin-6 (IL-6) activity in patients with NB to explore its relevance to the progressive CNS disease. Paired CSF and serum specimens were obtained from 11 patients who were diagnosed as having progressive NB based on careful clinical observation and from 11 patients with active Behçet's disease but lacking progressive CNS disease. IL-6 levels in the CSF and sera were determined using IL-6-dependent murine hybridoma MH60.BSF2 cells. All 11 patients with progressive NB showed marked elevation of CSF IL-6 activity [0.18–3.90 U/ml, 1.19 ± 1.18 (mean ± SD), normal range, <0.010 U/ml]. In contrast, only 5 of the 11 control patients showed very modest CSF IL-6 activity below 0.10 U/ml, and CSF IL-6 was not detected in the other 6 patients. There was no difference in the serum IL-6 activities of patients with progressive NB and control patients. There was no significant correlation of CSF IL-6 activity with serum IL-6 activity, CSF cell counts, CSF total protein levels, or the CSF/serum albumin quotient. These results indicate that persistent chronic CNS inflammation, as evidenced by the enhanced production of IL-6 within the CNS, plays an important role in the pathogenesis of progressive neuropsychiatric manifestations in Behçet's disease.</description><identifier>ISSN: 0090-1229</identifier><identifier>EISSN: 1090-2341</identifier><identifier>DOI: 10.1006/clin.1996.4268</identifier><identifier>PMID: 9000037</identifier><identifier>CODEN: CLIIAT</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Adult ; Behcet Syndrome - cerebrospinal fluid ; Behcet Syndrome - complications ; Behcet Syndrome - etiology ; Biological and medical sciences ; Central Nervous System Diseases - blood ; Central Nervous System Diseases - cerebrospinal fluid ; Central Nervous System Diseases - complications ; Female ; Humans ; Immunoglobulin M - cerebrospinal fluid ; Interleukin-6 - blood ; Interleukin-6 - cerebrospinal fluid ; Male ; Medical sciences ; Middle Aged ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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The present study examined cerebrospinal fluid (CSF) interleukin-6 (IL-6) activity in patients with NB to explore its relevance to the progressive CNS disease. Paired CSF and serum specimens were obtained from 11 patients who were diagnosed as having progressive NB based on careful clinical observation and from 11 patients with active Behçet's disease but lacking progressive CNS disease. IL-6 levels in the CSF and sera were determined using IL-6-dependent murine hybridoma MH60.BSF2 cells. All 11 patients with progressive NB showed marked elevation of CSF IL-6 activity [0.18–3.90 U/ml, 1.19 ± 1.18 (mean ± SD), normal range, <0.010 U/ml]. In contrast, only 5 of the 11 control patients showed very modest CSF IL-6 activity below 0.10 U/ml, and CSF IL-6 was not detected in the other 6 patients. There was no difference in the serum IL-6 activities of patients with progressive NB and control patients. There was no significant correlation of CSF IL-6 activity with serum IL-6 activity, CSF cell counts, CSF total protein levels, or the CSF/serum albumin quotient. These results indicate that persistent chronic CNS inflammation, as evidenced by the enhanced production of IL-6 within the CNS, plays an important role in the pathogenesis of progressive neuropsychiatric manifestations in Behçet's disease.</description><subject>Adult</subject><subject>Behcet Syndrome - cerebrospinal fluid</subject><subject>Behcet Syndrome - complications</subject><subject>Behcet Syndrome - etiology</subject><subject>Biological and medical sciences</subject><subject>Central Nervous System Diseases - blood</subject><subject>Central Nervous System Diseases - cerebrospinal fluid</subject><subject>Central Nervous System Diseases - complications</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin M - cerebrospinal fluid</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-6 - cerebrospinal fluid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Sarcoidosis. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Time Factors</topic><toplevel>online_resources</toplevel><creatorcontrib>Hirohata, Shunsei</creatorcontrib><creatorcontrib>Isshi, Kunio</creatorcontrib><creatorcontrib>Oguchi, Hiroko</creatorcontrib><creatorcontrib>Ohse, Toru</creatorcontrib><creatorcontrib>Haraoka, Hitomi</creatorcontrib><creatorcontrib>Takeuchi, Akiteru</creatorcontrib><creatorcontrib>Hashimoto, Takashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical immunology and immunopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hirohata, Shunsei</au><au>Isshi, Kunio</au><au>Oguchi, Hiroko</au><au>Ohse, Toru</au><au>Haraoka, Hitomi</au><au>Takeuchi, Akiteru</au><au>Hashimoto, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebrospinal Fluid Interleukin-6 in Progressive Neuro-Behçet's Syndrome</atitle><jtitle>Clinical immunology and immunopathology</jtitle><addtitle>Clin Immunol Immunopathol</addtitle><date>1997-01</date><risdate>1997</risdate><volume>82</volume><issue>1</issue><spage>12</spage><epage>17</epage><pages>12-17</pages><issn>0090-1229</issn><eissn>1090-2341</eissn><coden>CLIIAT</coden><abstract>Central nervous system (CNS) involvement in Behçet's disease, usually called neuro-Behçet's syndrome (NB), is one of the most serious complications of the disease. The present study examined cerebrospinal fluid (CSF) interleukin-6 (IL-6) activity in patients with NB to explore its relevance to the progressive CNS disease. Paired CSF and serum specimens were obtained from 11 patients who were diagnosed as having progressive NB based on careful clinical observation and from 11 patients with active Behçet's disease but lacking progressive CNS disease. IL-6 levels in the CSF and sera were determined using IL-6-dependent murine hybridoma MH60.BSF2 cells. All 11 patients with progressive NB showed marked elevation of CSF IL-6 activity [0.18–3.90 U/ml, 1.19 ± 1.18 (mean ± SD), normal range, <0.010 U/ml]. In contrast, only 5 of the 11 control patients showed very modest CSF IL-6 activity below 0.10 U/ml, and CSF IL-6 was not detected in the other 6 patients. There was no difference in the serum IL-6 activities of patients with progressive NB and control patients. There was no significant correlation of CSF IL-6 activity with serum IL-6 activity, CSF cell counts, CSF total protein levels, or the CSF/serum albumin quotient. These results indicate that persistent chronic CNS inflammation, as evidenced by the enhanced production of IL-6 within the CNS, plays an important role in the pathogenesis of progressive neuropsychiatric manifestations in Behçet's disease.</abstract><cop>San Diego, CA</cop><cop>New York, NY</cop><cop>Boston</cop><pub>Elsevier Inc</pub><pmid>9000037</pmid><doi>10.1006/clin.1996.4268</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Behcet Syndrome - cerebrospinal fluid Behcet Syndrome - complications Behcet Syndrome - etiology Biological and medical sciences Central Nervous System Diseases - blood Central Nervous System Diseases - cerebrospinal fluid Central Nervous System Diseases - complications Female Humans Immunoglobulin M - cerebrospinal fluid Interleukin-6 - blood Interleukin-6 - cerebrospinal fluid Male Medical sciences Middle Aged Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Time Factors |
| title | Cerebrospinal Fluid Interleukin-6 in Progressive Neuro-Behçet's Syndrome |
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