Bcl2 is the guardian of microtubule integrity

We have investigated the ability of several drugs commonly used in the treatment of human cancer to induce bcl2 phosphorylation and cell death in human cell lines derived from acute leukemia, lymphoma, breast cancer, and prostate cancer. The results of this analysis indicate that drugs affecting the...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1997-01, Vol.57 (2), p.229-233
Hauptverfasser:	HALDAR, S, BASU, A, CROCE, C. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects Biological and medical sciences Chronic Disease G2 Phase General aspects Humans Leukemia - metabolism Leukemia - pathology Lymphoma, B-Cell - drug therapy Lymphoma, B-Cell - metabolism Male Medical sciences Microtubules - drug effects Paclitaxel - analogs & derivatives Paclitaxel - pharmacology Pharmacology. Drug treatments Phosphorylation Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism Proto-Oncogene Proteins c-bcl-2 - physiology Taxoids Tumor Cells, Cultured - drug effects
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