Delivery of metered dose inhaler aerosols to paralyzed and nonparalyzed rabbits

OBJECTIVE To assess whether paralysis alters pulmonary deposition of albuterol delivered by metered dose inhaler and spacer to small animals. DESIGN A parallel group study of intubated and ventilated rabbits. INTERVENTIONS Animals in group 1 (n = 7) were paralyzed with intravenous pancuronium, and v...

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Veröffentlicht in:	Critical care medicine 1997-01, Vol.25 (1), p.140-144
Hauptverfasser:	Fok, Tai-Fai, Al-Essa, Mazen, Monkman, Shelley, Dolovich, Myrna, Girard, Lisa, Coates, Geoffrey, Kirpalani, Haresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Albuterol - administration & dosage Albuterol - metabolism Animals Biological and medical sciences Bronchodilator Agents - administration & dosage Bronchodilator Agents - metabolism Lung - metabolism Medical sciences Nebulizers and Vaporizers Paralysis - metabolism Pharmacology. Drug treatments Rabbits Respiration Respiration, Artificial Respiratory system
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