Retinoic acid and IFN inhibition of cell proliferation is associated with apoptosis in squamous carcinoma cell lines : Role of IRF-1 and TGase II-dependent pathways

Both retinoids and IFNs are known to inhibit proliferation of many normal and transformed cells and to have an in vivo antitumor effect against a variety of cancers, including squamous cell carcinoma. Because the combination of IFNs and all-trans retinoic acid (RA) could improve their antitumor effe...

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Veröffentlicht in:	Cell growth & differentiation 1997, Vol.8 (1), p.91-100
Hauptverfasser:	GIANDOMENICO, V, LANCILLOTTI, F, FIORUCCI, G, PERCARIO, Z. A, RIVABENE, R, MALORNI, W, AFFABRIS, E, ROMEO, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Apoptosis - drug effects Biological and medical sciences Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Division - drug effects DNA Fragmentation DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene Expression Regulation General aspects GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism GTP-Binding Proteins Humans Interferon Regulatory Factor-1 Interferon-alpha - pharmacology Medical sciences Pharmacology. Drug treatments Phosphoproteins - genetics Phosphoproteins - metabolism Recombinant Proteins Transglutaminases - genetics Transglutaminases - metabolism Tretinoin - pharmacology Tumor Cells, Cultured
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