Diagnosis of Measles with an IgM Capture EIA: The Optimal Timing of Specimen Collection after Rash Onset
The optimal timing for collection of a single serum specimen to diagnose measles by using a monoclonal antibody-capture EIA was evaluated. Results of testing paired serum samples from 166 measles cases with at least 1 IgM-positive specimen were analyzed. Among persons whose second samples were IgM-p...
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| Veröffentlicht in: | The Journal of infectious diseases 1997-01, Vol.175 (1), p.195-199 |
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| container_title | The Journal of infectious diseases |
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| creator | Helfand, Rita F. Heath, Janet L. Anderson, Larry J. Maes, Edmond F. Guris, Dalya Bellini, William J. |
| description | The optimal timing for collection of a single serum specimen to diagnose measles by using a monoclonal antibody-capture EIA was evaluated. Results of testing paired serum samples from 166 measles cases with at least 1 IgM-positive specimen were analyzed. Among persons whose second samples were IgM-positive, the seropositivity rate for first samples was 77% when collected within 72 hand 100% when collected 4-11 days after rash onset. Among unvaccinated persons whose first samples were IgM-positive, the rate for IgM positivity of second specimens declined from 100% at 4 days to 94% at 4 weeks after rash onset, then declined further to 63% at 5 weeks. Some previously vaccinated persons became IgM-negative during the third week after rash onset. In general, a single serum specimen collected between 72 hand 4 weeks after rash onset can be used to diagnose most cases of measles with an IgM capture EIA. |
| doi_str_mv | 10.1093/infdis/175.1.195 |
| format | Article |
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Results of testing paired serum samples from 166 measles cases with at least 1 IgM-positive specimen were analyzed. Among persons whose second samples were IgM-positive, the seropositivity rate for first samples was 77% when collected within 72 hand 100% when collected 4-11 days after rash onset. Among unvaccinated persons whose first samples were IgM-positive, the rate for IgM positivity of second specimens declined from 100% at 4 days to 94% at 4 weeks after rash onset, then declined further to 63% at 5 weeks. Some previously vaccinated persons became IgM-negative during the third week after rash onset. In general, a single serum specimen collected between 72 hand 4 weeks after rash onset can be used to diagnose most cases of measles with an IgM capture EIA.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/175.1.195</identifier><identifier>PMID: 8985220</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adolescent ; Adult ; Antibodies ; Antibodies, Viral - blood ; Biological and medical sciences ; Blood Specimen Collection ; Child ; Child, Preschool ; Concise Communications ; Diseases ; Epidemiology ; Exanthema ; Human viral diseases ; Humans ; Immunoenzyme Techniques ; Immunoglobulin M - blood ; Infant ; Infections ; Infectious diseases ; Measles ; Measles - diagnosis ; Measles Vaccine - immunology ; Measles vaccines ; measles virus ; Measles virus - immunology ; Medical sciences ; Middle Aged ; Preventive medicine ; Specimens ; Time Factors ; Vaccination ; Viral diseases ; Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><ispartof>The Journal of infectious diseases, 1997-01, Vol.175 (1), p.195-199</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 by the University of Chicago 1997</rights><rights>1997 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-e8da00661425c1b793ec30252d363d1fd2859e578113d2155fdb83a5665c30b73</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30130017$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30130017$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,1578,4010,27900,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2542694$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8985220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Helfand, Rita F.</creatorcontrib><creatorcontrib>Heath, Janet L.</creatorcontrib><creatorcontrib>Anderson, Larry J.</creatorcontrib><creatorcontrib>Maes, Edmond F.</creatorcontrib><creatorcontrib>Guris, Dalya</creatorcontrib><creatorcontrib>Bellini, William J.</creatorcontrib><title>Diagnosis of Measles with an IgM Capture EIA: The Optimal Timing of Specimen Collection after Rash Onset</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>The optimal timing for collection of a single serum specimen to diagnose measles by using a monoclonal antibody-capture EIA was evaluated. Results of testing paired serum samples from 166 measles cases with at least 1 IgM-positive specimen were analyzed. Among persons whose second samples were IgM-positive, the seropositivity rate for first samples was 77% when collected within 72 hand 100% when collected 4-11 days after rash onset. Among unvaccinated persons whose first samples were IgM-positive, the rate for IgM positivity of second specimens declined from 100% at 4 days to 94% at 4 weeks after rash onset, then declined further to 63% at 5 weeks. Some previously vaccinated persons became IgM-negative during the third week after rash onset. In general, a single serum specimen collected between 72 hand 4 weeks after rash onset can be used to diagnose most cases of measles with an IgM capture EIA.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antibodies, Viral - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Specimen Collection</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Concise Communications</subject><subject>Diseases</subject><subject>Epidemiology</subject><subject>Exanthema</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulin M - blood</subject><subject>Infant</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Measles</subject><subject>Measles - diagnosis</subject><subject>Measles Vaccine - immunology</subject><subject>Measles vaccines</subject><subject>measles virus</subject><subject>Measles virus - immunology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Preventive medicine</subject><subject>Specimens</subject><subject>Time Factors</subject><subject>Vaccination</subject><subject>Viral diseases</subject><subject>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc2P0zAQxS0EWkrhzgXJQogLStcfcWJzW5WFrbSlaLdIiIvlJk7rktjBdgT89zhK6YELQrLsw_vNmxk_AJ5jtMBI0Etjm9qES1yyBV5gwR6AGWa0zIoC04dghhAhGeZCPAZPQjgihHJalBfgggvOCEEzcHhn1N66YAJ0DVxrFVod4A8TD1BZuNqv4VL1cfAaXq-u3sLtQcNNH02nWrg1nbH7sey-15XptIVL17a6isZZqJqoPbxT4QA3Nuj4FDxqVBv0s9M7B5_fX2-XN9nt5sNqeXWbVQyLmGleK4TS-DlhFd6VguqKIsJITQta46YmnAnNSo4xrQlmrKl3nCpWFCxxu5LOwevJt_fu-6BDlJ0JlW5bZbUbgix5mQ6j_wQx4zQfrzl4-Rd4dIO3aQlJCBXjEGNbNEGVdyF43cjep1_yvyRGcoxKTlHJFJXEMkWVSl6cfIddp-tzwSmbpL866SpUqm28slUy-IMRlpNC5Al7M2Fu6P-j6TFE5888RZgihMc9skk3IeqfZ135b7IoabK5-fJVFvyO3H9En-Sa_gZKusEE</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Helfand, Rita F.</creator><creator>Heath, Janet L.</creator><creator>Anderson, Larry J.</creator><creator>Maes, Edmond F.</creator><creator>Guris, Dalya</creator><creator>Bellini, William J.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>Diagnosis of Measles with an IgM Capture EIA: The Optimal Timing of Specimen Collection after Rash Onset</title><author>Helfand, Rita F. ; Heath, Janet L. ; Anderson, Larry J. ; Maes, Edmond F. ; Guris, Dalya ; Bellini, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-e8da00661425c1b793ec30252d363d1fd2859e578113d2155fdb83a5665c30b73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Antibodies</topic><topic>Antibodies, Viral - blood</topic><topic>Biological and medical sciences</topic><topic>Blood Specimen Collection</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Concise Communications</topic><topic>Diseases</topic><topic>Epidemiology</topic><topic>Exanthema</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulin M - blood</topic><topic>Infant</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Measles</topic><topic>Measles - diagnosis</topic><topic>Measles Vaccine - immunology</topic><topic>Measles vaccines</topic><topic>measles virus</topic><topic>Measles virus - immunology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Preventive medicine</topic><topic>Specimens</topic><topic>Time Factors</topic><topic>Vaccination</topic><topic>Viral diseases</topic><topic>Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Helfand, Rita F.</creatorcontrib><creatorcontrib>Heath, Janet L.</creatorcontrib><creatorcontrib>Anderson, Larry J.</creatorcontrib><creatorcontrib>Maes, Edmond F.</creatorcontrib><creatorcontrib>Guris, Dalya</creatorcontrib><creatorcontrib>Bellini, William J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Helfand, Rita F.</au><au>Heath, Janet L.</au><au>Anderson, Larry J.</au><au>Maes, Edmond F.</au><au>Guris, Dalya</au><au>Bellini, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnosis of Measles with an IgM Capture EIA: The Optimal Timing of Specimen Collection after Rash Onset</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J Infect Dis</stitle><addtitle>J Infect Dis</addtitle><date>1997-01</date><risdate>1997</risdate><volume>175</volume><issue>1</issue><spage>195</spage><epage>199</epage><pages>195-199</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The optimal timing for collection of a single serum specimen to diagnose measles by using a monoclonal antibody-capture EIA was evaluated. Results of testing paired serum samples from 166 measles cases with at least 1 IgM-positive specimen were analyzed. Among persons whose second samples were IgM-positive, the seropositivity rate for first samples was 77% when collected within 72 hand 100% when collected 4-11 days after rash onset. Among unvaccinated persons whose first samples were IgM-positive, the rate for IgM positivity of second specimens declined from 100% at 4 days to 94% at 4 weeks after rash onset, then declined further to 63% at 5 weeks. Some previously vaccinated persons became IgM-negative during the third week after rash onset. In general, a single serum specimen collected between 72 hand 4 weeks after rash onset can be used to diagnose most cases of measles with an IgM capture EIA.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>8985220</pmid><doi>10.1093/infdis/175.1.195</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of infectious diseases, 1997-01, Vol.175 (1), p.195-199 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Adult Antibodies Antibodies, Viral - blood Biological and medical sciences Blood Specimen Collection Child Child, Preschool Concise Communications Diseases Epidemiology Exanthema Human viral diseases Humans Immunoenzyme Techniques Immunoglobulin M - blood Infant Infections Infectious diseases Measles Measles - diagnosis Measles Vaccine - immunology Measles vaccines measles virus Measles virus - immunology Medical sciences Middle Aged Preventive medicine Specimens Time Factors Vaccination Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye |
| title | Diagnosis of Measles with an IgM Capture EIA: The Optimal Timing of Specimen Collection after Rash Onset |
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