Effect of 5-Hydroxytryptamine on Sodium- and Potassium-Dependent Adenosine Triphosphatase and Its Reactivity toward Ouabain

Activity of vertebrate Na+,K+-ATPase was inhibited by 5-hydroxytryptamine. Inhibition was reversible, and activity could be restored by dilution of 5-hydroxytryptamine (5HT). The ability of indole derivatives to inhibit depended on the presence of a net charge on the third atom of the indole C-3 sid...

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