The heterotrimeric G protein G alpha i2 mediates lysophosphatidic acid-stimulated induction of the c-fos gene in mouse fibroblasts

Lysophosphatidic acid (LPA) utilizes a heterotrimeric guanine nucleotide regulatory (G) protein-coupled receptor to activate the mitogen-activated protein kinase pathway and induce mitogenesis in fibroblasts and other cells. A single cell assay system was used to examine the functional interaction o...

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Veröffentlicht in:	The Journal of biological chemistry 1997-01, Vol.272 (2), p.773-781
Hauptverfasser:	Chuprun, J K, Raymond, J R, Blackshear, P J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Fibroblasts - metabolism Genes, fos GTP-Binding Protein alpha Subunit, Gi2 GTP-Binding Protein alpha Subunits, Gi-Go GTP-Binding Proteins - metabolism Insulin - pharmacology Lysophospholipids - pharmacology Mice Microinjections Pertussis Toxin Proto-Oncogene Proteins - metabolism Receptors, Cell Surface - metabolism Receptors, G-Protein-Coupled Receptors, Lysophosphatidic Acid Virulence Factors, Bordetella - pharmacology
Online-Zugang:	Volltext
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