Cholinergic activation of phosphoinositide signaling is impaired in Alzheimer's disease brain

The function of the phosphoinositide signal transduction system was compared in membranes from Alzheimer's disease (AD) and control postmortem brain. [ 3H]Phosphatidylinositol hydrolysis was concentration-dependently stimulated by GTP[S] and this was 40% lower than controls in AD prefrontal cor...

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Veröffentlicht in:	Neurobiology of aging 1997, Vol.18 (1), p.111-120
Hauptverfasser:	Jope, Richard S., Song, Ling, Powers, Richard E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - physiopathology Alzheimer's disease Biological and medical sciences Brain - physiopathology Brain Chemistry - drug effects Brain Chemistry - physiology Choline O-Acetyltransferase - metabolism Cholinergic Cholinergic Agonists - pharmacology Cholinesterase Inhibitors - pharmacology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female G-protein GTP-Binding Proteins - metabolism Guanosine 5'-O-(3-Thiotriphosphate) - pharmacology Humans Hydrolysis In Vitro Techniques Male Medical sciences Muscarinic stimulation Neurology Parasympathetic Nervous System - physiopathology Phosphatidylinositol Phosphatidylinositols - metabolism Phosphatidylinositols - physiology Phosphoinositide hydrolysis Signal Transduction - physiology
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