Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells

Alloreactive CTL clones and naive CTL precursor cells (CTLp) from TCR-transgenic mice were analyzed for their response in total and in TCR-associated kinase activation upon stimulation with the relevant class I allo-APCs. The responses were found to be stronger and more sustained for the CTL clone a...

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Veröffentlicht in:	The Journal of immunology (1950) 1997-01, Vol.158 (1), p.19-28
Hauptverfasser:	Anel, A, Martínez-Lorenzo, M J, Schmitt-Verhulst, A M, Boyer, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD8 Antigens - pharmacology Clone Cells Hematopoietic Stem Cells - drug effects Mice Mice, Inbred CBA Mice, Transgenic Phosphorylation Receptor-CD3 Complex, Antigen, T-Cell - drug effects Signal Transduction - drug effects T-Lymphocytes, Cytotoxic - drug effects Tyrosine - metabolism
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