In vivo measurement of T2 distributions and water contents in normal human brain
Using a 32‐echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had si...
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| Veröffentlicht in: | Magnetic resonance in medicine 1997-01, Vol.37 (1), p.34-43 |
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| container_title | Magnetic resonance in medicine |
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| creator | Whittall, Kenneth P Mackay, Alex L. Graeb, Douglas A. Nugent, Robert A. Li, David K. B. Paty, Donald W. |
| description | Using a 32‐echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T2 between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T2 of the main peak for both white and gray matter was from 70 to 86 ms. T2 distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. Thus, quantitative measurement and analysis of T2 relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. These differences may make short T2 components reliable markers for normal myelin. |
| doi_str_mv | 10.1002/mrm.1910370107 |
| format | Article |
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Thus, quantitative measurement and analysis of T2 relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. 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B.</creatorcontrib><creatorcontrib>Paty, Donald W.</creatorcontrib><title>In vivo measurement of T2 distributions and water contents in normal human brain</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Using a 32‐echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T2 between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T2 of the main peak for both white and gray matter was from 70 to 86 ms. T2 distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. Thus, quantitative measurement and analysis of T2 relaxation reveals differences in brain tissue water environments not discernible on conventional MR images. These differences may make short T2 components reliable markers for normal myelin.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Biological and medical sciences</subject><subject>Body Water - metabolism</subject><subject>Brain - anatomy & histology</subject><subject>Brain - metabolism</subject><subject>brain white and gray matter</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>myelin content</subject><subject>Myelin Proteins - analysis</subject><subject>Nervous system</subject><subject>Phantoms, Imaging</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>T2 relaxation</subject><subject>water content</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtPxCAUhYnR6PjYujNhYdxVL4-WstTxmfiK0cyS0EIjWqhCO-q_t2Ym4-qGe74D5ByE9gkcEwB64qM_JpIAE0BArKEJySnNaC75OpqA4JAxIvkW2k7pDQCkFHwTbZZSlAWDCXq8CXju5h32VqchWm9Dj7sGP1NsXOqjq4bedSFhHQz-0r2NuO5CP1IJu4BDF71u8evgdcBV1C7soo1Gt8nuLecOerm8eJ5eZ7cPVzfT09vMMeAiY4WsKGXUEmkMNJWh46aoDCtyAqQuaslrGH-uQYOhFaFCmJITTkUNsmgk20FHi3s_Yvc52NQr71Jt21YH2w1JiVIIRksyggdLcKi8NeojOq_jj1pGMOqHS12nWrdN1KF2aYXRnDPJ_96TC-zLtfZnJRNQfzWosQb1X4O6e7r7P43ebOEdE7XfK6-O76oQTORqdn-lxNl0NjuHS0XYL1t6iQY</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Whittall, Kenneth P</creator><creator>Mackay, Alex L.</creator><creator>Graeb, Douglas A.</creator><creator>Nugent, Robert A.</creator><creator>Li, David K. 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B. ; Paty, Donald W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3047-369b2232e19dd0fbd23696bd365101c6c94c0319a0a0d2b1277d841427c096f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Biological and medical sciences</topic><topic>Body Water - metabolism</topic><topic>Brain - anatomy & histology</topic><topic>Brain - metabolism</topic><topic>brain white and gray matter</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>myelin content</topic><topic>Myelin Proteins - analysis</topic><topic>Nervous system</topic><topic>Phantoms, Imaging</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>T2 relaxation</topic><topic>water content</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whittall, Kenneth P</creatorcontrib><creatorcontrib>Mackay, Alex L.</creatorcontrib><creatorcontrib>Graeb, Douglas A.</creatorcontrib><creatorcontrib>Nugent, Robert A.</creatorcontrib><creatorcontrib>Li, David K. B.</creatorcontrib><creatorcontrib>Paty, Donald W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whittall, Kenneth P</au><au>Mackay, Alex L.</au><au>Graeb, Douglas A.</au><au>Nugent, Robert A.</au><au>Li, David K. B.</au><au>Paty, Donald W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo measurement of T2 distributions and water contents in normal human brain</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>1997-01</date><risdate>1997</risdate><volume>37</volume><issue>1</issue><spage>34</spage><epage>43</epage><pages>34-43</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Using a 32‐echo imaging pulse sequence, T2 relaxation decay curves were acquired from five white‐ and six gray‐matter brain structures outlined in 12 normal volunteers. The water contents of white and gray matter were 0.71 (0.01) and 0.83 (0.03) g/ml, respectively. All white‐matter structures had significantly higher myelin water percentages (signal percentage with T2 between 10 and 50 ms) than all gray‐matter structures. The range in geometric mean T2 of the main peak for both white and gray matter was from 70 to 86 ms. T2 distributions from the posterior internal capsules and splenium of the corpus callosum were significantly wider (width is related to water environment inhomogeneity) than those from any other white‐ or gray‐matter structures. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Algorithms Biological and medical sciences Body Water - metabolism Brain - anatomy & histology Brain - metabolism brain white and gray matter Female Humans Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging - methods Magnetic Resonance Spectroscopy Male Medical sciences myelin content Myelin Proteins - analysis Nervous system Phantoms, Imaging Radiodiagnosis. Nmr imagery. Nmr spectrometry T2 relaxation water content |
| title | In vivo measurement of T2 distributions and water contents in normal human brain |
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