A study of pentylenetetrazol kindling in rats and mice

The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determines in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice p...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1988-12, Vol.31 (4), p.867-870
Hauptverfasser:	Craig, Charles R., Colasanti, Brenda K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Drug Administration Schedule Drug Tolerance Kindling Kindling, Neurologic Mice Pentylenetetrazol Pentylenetetrazole - administration & dosage Pentylenetetrazole - pharmacology Rats Rats, Inbred Strains Social Isolation Time Factors Tolerance
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Zusammenfassung:	The effect of repeated injection of pentylenetetrazol on pentylenetetrazol seizure thresholds was determines in mice and rats. Once per week treatment of rats with pentylenetetrazol resulted in the development of a state of kindling. On the other hand, when pentylenetetrazol was administered twice per week, a phenomenon resembling tolerance was observed. In mice, it was not possible to demonstrate kindling under experimental conditions utilizing either one or two treatments with PTZ per week.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(88)90397-8