The microtubule-affecting drug paclitaxel has antiangiogenic activity
Endothelial cell migration is a critical event during angiogenesis, and inhibitors of cell motility can affect the angiogenic process. Paclitaxel (Taxol(R)), a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits motility and invasiveness of several cell types. The aim of this study was t...
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| Veröffentlicht in: | Clinical cancer research 1996-11, Vol.2 (11), p.1843-1849 |
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| container_title | Clinical cancer research |
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| creator | BELOTTI, D VERGANI, V DRUDIS, T BORSOTTI, P PITELLI, M. R VIALE, G GIAVAZZI, R TARABOLETTI, G |
| description | Endothelial cell migration is a critical event during angiogenesis, and inhibitors of cell motility can affect the angiogenic
process. Paclitaxel (Taxol(R)), a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits motility and invasiveness
of several cell types. The aim of this study was to investigate the effect of paclitaxel on endothelial cell functions and
on angiogenesis. In vivo, paclitaxel (20-28 mg/kg i.v.) significantly inhibited the angiogenic response induced by tumor cell
supernatant embedded in a pellet of reconstituted basement membrane (Matrigel) injected s.c. into C57BL/6N mice. In vitro,
paclitaxel inhibited endothelial cell proliferation, motility, invasiveness, and cord formation on Matrigel in a dose-dependent
manner. The antiangiogenic activity of paclitaxel was not linked to its cytotoxicity, since inhibition of endothelial cell
chemotaxis and invasiveness occurred at drug concentrations which did not affect endothelial cell proliferation. Another cytotoxic
drug, cisplatin, that inhibited endothelial cell proliferation in vitro, did not affect angiogenesis in vivo. These data indicate
that paclitaxel has a strong antiangiogenic activity, a property that might contribute to its antineoplastic activity in vivo. |
| format | Article |
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process. Paclitaxel (Taxol(R)), a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits motility and invasiveness
of several cell types. The aim of this study was to investigate the effect of paclitaxel on endothelial cell functions and
on angiogenesis. In vivo, paclitaxel (20-28 mg/kg i.v.) significantly inhibited the angiogenic response induced by tumor cell
supernatant embedded in a pellet of reconstituted basement membrane (Matrigel) injected s.c. into C57BL/6N mice. In vitro,
paclitaxel inhibited endothelial cell proliferation, motility, invasiveness, and cord formation on Matrigel in a dose-dependent
manner. The antiangiogenic activity of paclitaxel was not linked to its cytotoxicity, since inhibition of endothelial cell
chemotaxis and invasiveness occurred at drug concentrations which did not affect endothelial cell proliferation. Another cytotoxic
drug, cisplatin, that inhibited endothelial cell proliferation in vitro, did not affect angiogenesis in vivo. These data indicate
that paclitaxel has a strong antiangiogenic activity, a property that might contribute to its antineoplastic activity in vivo.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9816139</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Animals ; Antineoplastic agents ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Cell Movement - drug effects ; Cells, Cultured ; Cisplatin - pharmacology ; Collagen - metabolism ; Drug Combinations ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - physiology ; General aspects ; Laminin - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Microtubules - drug effects ; Neoplasms, Experimental - blood supply ; Neoplasms, Experimental - drug therapy ; Neovascularization, Pathologic - prevention & control ; Paclitaxel - pharmacology ; Pharmacology. Drug treatments ; Proteoglycans - metabolism</subject><ispartof>Clinical cancer research, 1996-11, Vol.2 (11), p.1843-1849</ispartof><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2482850$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9816139$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BELOTTI, D</creatorcontrib><creatorcontrib>VERGANI, V</creatorcontrib><creatorcontrib>DRUDIS, T</creatorcontrib><creatorcontrib>BORSOTTI, P</creatorcontrib><creatorcontrib>PITELLI, M. R</creatorcontrib><creatorcontrib>VIALE, G</creatorcontrib><creatorcontrib>GIAVAZZI, R</creatorcontrib><creatorcontrib>TARABOLETTI, G</creatorcontrib><title>The microtubule-affecting drug paclitaxel has antiangiogenic activity</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Endothelial cell migration is a critical event during angiogenesis, and inhibitors of cell motility can affect the angiogenic
process. Paclitaxel (Taxol(R)), a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits motility and invasiveness
of several cell types. The aim of this study was to investigate the effect of paclitaxel on endothelial cell functions and
on angiogenesis. In vivo, paclitaxel (20-28 mg/kg i.v.) significantly inhibited the angiogenic response induced by tumor cell
supernatant embedded in a pellet of reconstituted basement membrane (Matrigel) injected s.c. into C57BL/6N mice. In vitro,
paclitaxel inhibited endothelial cell proliferation, motility, invasiveness, and cord formation on Matrigel in a dose-dependent
manner. The antiangiogenic activity of paclitaxel was not linked to its cytotoxicity, since inhibition of endothelial cell
chemotaxis and invasiveness occurred at drug concentrations which did not affect endothelial cell proliferation. Another cytotoxic
drug, cisplatin, that inhibited endothelial cell proliferation in vitro, did not affect angiogenesis in vivo. These data indicate
that paclitaxel has a strong antiangiogenic activity, a property that might contribute to its antineoplastic activity in vivo.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents, Phytogenic - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Movement - drug effects</subject><subject>Cells, Cultured</subject><subject>Cisplatin - pharmacology</subject><subject>Collagen - metabolism</subject><subject>Drug Combinations</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - physiology</subject><subject>General aspects</subject><subject>Laminin - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Microtubules - drug effects</subject><subject>Neoplasms, Experimental - blood supply</subject><subject>Neoplasms, Experimental - drug therapy</subject><subject>Neovascularization, Pathologic - prevention & control</subject><subject>Paclitaxel - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteoglycans - metabolism</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9z0tLxDAQB_AiyrqufgShBxEvhbzaJkdZ1gcseFnPYTpN2kgfa5L6-PYWtniagf-PPzNnyZrmeZlxVuTn805KmRHB2WVyFcIHIVRQIlbJSklaUK7Wye7QmrR36Mc4VVNnMrDWYHRDk9Z-atIjYOci_JgubSGkMEQHQ-PGxgwOU5jll4u_18mFhS6Ym2Vukven3WH7ku3fnl-3j_usZYWMmVCMEIECKK8gxxINoYSCKiuFyjKVC-RcWuR5BbxWSqAV9XwwraiqubV8k9yfeo9-_JxMiLp3AU3XwWDGKehSloVkQszwdoFT1ZtaH73rwf_q5e85v1tyCAid9TCgC_-MCclkTmb2cGKta9pv543GGRrvTTDgsdVMU6qpFJz_ASU5b_k</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>BELOTTI, D</creator><creator>VERGANI, V</creator><creator>DRUDIS, T</creator><creator>BORSOTTI, P</creator><creator>PITELLI, M. 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R ; VIALE, G ; GIAVAZZI, R ; TARABOLETTI, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h268t-492004c4a13ba5c7ce0101a97b9c9f2954c338fc35ba3d994cf4d1041b19d3ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents, Phytogenic - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Movement - drug effects</topic><topic>Cells, Cultured</topic><topic>Cisplatin - pharmacology</topic><topic>Collagen - metabolism</topic><topic>Drug Combinations</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - physiology</topic><topic>General aspects</topic><topic>Laminin - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Microtubules - drug effects</topic><topic>Neoplasms, Experimental - blood supply</topic><topic>Neoplasms, Experimental - drug therapy</topic><topic>Neovascularization, Pathologic - prevention & control</topic><topic>Paclitaxel - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteoglycans - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BELOTTI, D</creatorcontrib><creatorcontrib>VERGANI, V</creatorcontrib><creatorcontrib>DRUDIS, T</creatorcontrib><creatorcontrib>BORSOTTI, P</creatorcontrib><creatorcontrib>PITELLI, M. R</creatorcontrib><creatorcontrib>VIALE, G</creatorcontrib><creatorcontrib>GIAVAZZI, R</creatorcontrib><creatorcontrib>TARABOLETTI, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BELOTTI, D</au><au>VERGANI, V</au><au>DRUDIS, T</au><au>BORSOTTI, P</au><au>PITELLI, M. R</au><au>VIALE, G</au><au>GIAVAZZI, R</au><au>TARABOLETTI, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The microtubule-affecting drug paclitaxel has antiangiogenic activity</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>2</volume><issue>11</issue><spage>1843</spage><epage>1849</epage><pages>1843-1849</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Endothelial cell migration is a critical event during angiogenesis, and inhibitors of cell motility can affect the angiogenic
process. Paclitaxel (Taxol(R)), a microtubule-stabilizing antineoplastic cytotoxic drug, inhibits motility and invasiveness
of several cell types. The aim of this study was to investigate the effect of paclitaxel on endothelial cell functions and
on angiogenesis. In vivo, paclitaxel (20-28 mg/kg i.v.) significantly inhibited the angiogenic response induced by tumor cell
supernatant embedded in a pellet of reconstituted basement membrane (Matrigel) injected s.c. into C57BL/6N mice. In vitro,
paclitaxel inhibited endothelial cell proliferation, motility, invasiveness, and cord formation on Matrigel in a dose-dependent
manner. The antiangiogenic activity of paclitaxel was not linked to its cytotoxicity, since inhibition of endothelial cell
chemotaxis and invasiveness occurred at drug concentrations which did not affect endothelial cell proliferation. Another cytotoxic
drug, cisplatin, that inhibited endothelial cell proliferation in vitro, did not affect angiogenesis in vivo. These data indicate
that paclitaxel has a strong antiangiogenic activity, a property that might contribute to its antineoplastic activity in vivo.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9816139</pmid><tpages>7</tpages></addata></record> |
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| ispartof | Clinical cancer research, 1996-11, Vol.2 (11), p.1843-1849 |
| issn | 1078-0432 1557-3265 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antineoplastic agents Antineoplastic Agents - pharmacology Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Cell Movement - drug effects Cells, Cultured Cisplatin - pharmacology Collagen - metabolism Drug Combinations Endothelium, Vascular - drug effects Endothelium, Vascular - physiology General aspects Laminin - metabolism Male Medical sciences Mice Mice, Inbred C57BL Microtubules - drug effects Neoplasms, Experimental - blood supply Neoplasms, Experimental - drug therapy Neovascularization, Pathologic - prevention & control Paclitaxel - pharmacology Pharmacology. Drug treatments Proteoglycans - metabolism |
| title | The microtubule-affecting drug paclitaxel has antiangiogenic activity |
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