Cyclosporin A and PSC 833 prevent up-regulation of MDR1 expression by anthracyclines in a human multidrug-resistant cell line

We have previously demonstrated that within 24 h of exposure of the CEM/A7R cell line to epirubicin (EPI), MDR1 gene expression is induced. The aim of the current study was to investigate the role of cyclosporin A (CyA) and PSC 833, two biochemical modulators of the classical multidrug-resistant phe...

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Veröffentlicht in:	Clinical cancer research 1996-04, Vol.2 (4), p.713-720
Hauptverfasser:	HU, X. F, SLATER, A, WALL, D. M, PARKIN, J. D, KANTHARIDIS, P, ZALCBERG, J. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - pharmacology Antineoplastic agents ATP-Binding Cassette, Sub-Family B, Member 1 - analysis ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - genetics Biological and medical sciences Cyclosporine - pharmacology Cyclosporins - pharmacology Dose-Response Relationship, Drug Drug Resistance, Multiple Drug Resistance, Neoplasm Epirubicin - pharmacology General aspects Humans Medical sciences Pharmacology. Drug treatments RNA, Messenger Tumor Cells, Cultured Up-Regulation
Online-Zugang:	Volltext
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