Effects of suberogorgin and its derivates on learning and memory in mice
To study the relationship between the effects of suberogorgin (Sub) and its derivates on memory and their anti-acetylcholinesterase (AChE) actions. The step-down latency (SDL) and the escape latency (EL) of mice were determined at the same time in a passive avoidance task after Sub, N-suberogorgamid...
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| Veröffentlicht in: | Zhōngguó yàolĭ xuébào 1996-05, Vol.17 (3), p.215-218 |
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| creator | PENG, W.-D XU, S.-B PENG, X |
| description | To study the relationship between the effects of suberogorgin (Sub) and its derivates on memory and their anti-acetylcholinesterase (AChE) actions.
The step-down latency (SDL) and the escape latency (EL) of mice were determined at the same time in a passive avoidance task after Sub, N-suberogorgamide-N-N-dicyclohexyl urea (Sub-DU), or N-cyclohexyl suberogorgamide (N-CS) was injected i.p. The AChE activities in brain hemogenates were determined with colorimetry.
Sub 1.9, Sub-DU 3.0, or physostigmine (Phys) 0.15 mg.kg-1 obviously lengthened the SDL by 195%, 271%, and 210%, and shortened the EL by 56%, 61%, and 33%, and the two formers inhibited the brain AChE activities by 17% and 19%, respectively in aging (3-4 months) mice. These actions were decreased in a dose-dependent manner when Sub or Sub-DU was increased to 2.9-4.3 or 4.5-6.7 mg.kg-1 respectively. Sub 1.9, Sub-DU 2.0, and Phys 0.15 mg.kg-1 also lengthened the SDL by 187%, 209%, and 152%, and shortened the EL by 52%, 62%, and 57%, respectively in aged (12-14 months) mice. Sub 1.3-1.9, Sub-DU 0.9-2.0, or Phys 0.15 mg.kg-1 reversed the cycloheximide- or scopolamine-induced disruptions of memory retention. No obvious effect of N-CS on the acquisition of memory and the AChE activity in mice was observed.
The improvements of Sub and Sub-DU on memory were chiefly related to their anti-AChE actions. |
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The step-down latency (SDL) and the escape latency (EL) of mice were determined at the same time in a passive avoidance task after Sub, N-suberogorgamide-N-N-dicyclohexyl urea (Sub-DU), or N-cyclohexyl suberogorgamide (N-CS) was injected i.p. The AChE activities in brain hemogenates were determined with colorimetry.
Sub 1.9, Sub-DU 3.0, or physostigmine (Phys) 0.15 mg.kg-1 obviously lengthened the SDL by 195%, 271%, and 210%, and shortened the EL by 56%, 61%, and 33%, and the two formers inhibited the brain AChE activities by 17% and 19%, respectively in aging (3-4 months) mice. These actions were decreased in a dose-dependent manner when Sub or Sub-DU was increased to 2.9-4.3 or 4.5-6.7 mg.kg-1 respectively. Sub 1.9, Sub-DU 2.0, and Phys 0.15 mg.kg-1 also lengthened the SDL by 187%, 209%, and 152%, and shortened the EL by 52%, 62%, and 57%, respectively in aged (12-14 months) mice. Sub 1.3-1.9, Sub-DU 0.9-2.0, or Phys 0.15 mg.kg-1 reversed the cycloheximide- or scopolamine-induced disruptions of memory retention. No obvious effect of N-CS on the acquisition of memory and the AChE activity in mice was observed.
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The step-down latency (SDL) and the escape latency (EL) of mice were determined at the same time in a passive avoidance task after Sub, N-suberogorgamide-N-N-dicyclohexyl urea (Sub-DU), or N-cyclohexyl suberogorgamide (N-CS) was injected i.p. The AChE activities in brain hemogenates were determined with colorimetry.
Sub 1.9, Sub-DU 3.0, or physostigmine (Phys) 0.15 mg.kg-1 obviously lengthened the SDL by 195%, 271%, and 210%, and shortened the EL by 56%, 61%, and 33%, and the two formers inhibited the brain AChE activities by 17% and 19%, respectively in aging (3-4 months) mice. These actions were decreased in a dose-dependent manner when Sub or Sub-DU was increased to 2.9-4.3 or 4.5-6.7 mg.kg-1 respectively. Sub 1.9, Sub-DU 2.0, and Phys 0.15 mg.kg-1 also lengthened the SDL by 187%, 209%, and 152%, and shortened the EL by 52%, 62%, and 57%, respectively in aged (12-14 months) mice. Sub 1.3-1.9, Sub-DU 0.9-2.0, or Phys 0.15 mg.kg-1 reversed the cycloheximide- or scopolamine-induced disruptions of memory retention. No obvious effect of N-CS on the acquisition of memory and the AChE activity in mice was observed.
The improvements of Sub and Sub-DU on memory were chiefly related to their anti-AChE actions.</description><subject>Acetylcholinesterase - metabolism</subject><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Female</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Retention (Psychology) - drug effects</subject><subject>Sesquiterpenes - pharmacology</subject><issn>0253-9756</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9zz1rwzAQBmANLWlI8xMKHko3g-zThzWWkDaFQJfsRrJORsWWXcku5N_XpKa3vHDvw8HdkS0tOeRKcvFA9il90WVEKatSbchGVUUpodqS09E5bKaUDS5Ls8E4tENsfch0sJlf9haj_9ETLiJkHeoYfGhvbY_9EK_ZYnvf4CO5d7pLuF9zRy5vx8vhlJ8_3z8Or-d8LIFPuXLCKmcYWC0cBUElctsAlIJSC4U0oKhRYIRDIcBYxmwhCqaQ8RvckZe_s2McvmdMU9371GDX6YDDnGpZScEVlwt8WuFserT1GH2v47VeP1_657XXqdGdizo0Pv0zKChjBYVfJDdgtw</recordid><startdate>19960501</startdate><enddate>19960501</enddate><creator>PENG, W.-D</creator><creator>XU, S.-B</creator><creator>PENG, X</creator><general>Science Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19960501</creationdate><title>Effects of suberogorgin and its derivates on learning and memory in mice</title><author>PENG, W.-D ; XU, S.-B ; PENG, X</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p235t-9f6d9fb43da6f03607e5dc332600d317b390b93b6fe663bd44d16149e45e5dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Acetylcholinesterase - metabolism</topic><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Female</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease)</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopharmacology</topic><topic>Retention (Psychology) - drug effects</topic><topic>Sesquiterpenes - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>PENG, W.-D</creatorcontrib><creatorcontrib>XU, S.-B</creatorcontrib><creatorcontrib>PENG, X</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhōngguó yàolĭ xuébào</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PENG, W.-D</au><au>XU, S.-B</au><au>PENG, X</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of suberogorgin and its derivates on learning and memory in mice</atitle><jtitle>Zhōngguó yàolĭ xuébào</jtitle><addtitle>Zhongguo Yao Li Xue Bao</addtitle><date>1996-05-01</date><risdate>1996</risdate><volume>17</volume><issue>3</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0253-9756</issn><abstract>To study the relationship between the effects of suberogorgin (Sub) and its derivates on memory and their anti-acetylcholinesterase (AChE) actions.
The step-down latency (SDL) and the escape latency (EL) of mice were determined at the same time in a passive avoidance task after Sub, N-suberogorgamide-N-N-dicyclohexyl urea (Sub-DU), or N-cyclohexyl suberogorgamide (N-CS) was injected i.p. The AChE activities in brain hemogenates were determined with colorimetry.
Sub 1.9, Sub-DU 3.0, or physostigmine (Phys) 0.15 mg.kg-1 obviously lengthened the SDL by 195%, 271%, and 210%, and shortened the EL by 56%, 61%, and 33%, and the two formers inhibited the brain AChE activities by 17% and 19%, respectively in aging (3-4 months) mice. These actions were decreased in a dose-dependent manner when Sub or Sub-DU was increased to 2.9-4.3 or 4.5-6.7 mg.kg-1 respectively. Sub 1.9, Sub-DU 2.0, and Phys 0.15 mg.kg-1 also lengthened the SDL by 187%, 209%, and 152%, and shortened the EL by 52%, 62%, and 57%, respectively in aged (12-14 months) mice. Sub 1.3-1.9, Sub-DU 0.9-2.0, or Phys 0.15 mg.kg-1 reversed the cycloheximide- or scopolamine-induced disruptions of memory retention. No obvious effect of N-CS on the acquisition of memory and the AChE activity in mice was observed.
The improvements of Sub and Sub-DU on memory were chiefly related to their anti-AChE actions.</abstract><cop>Beijing</cop><pub>Science Press</pub><pmid>9812738</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Zhōngguó yàolĭ xuébào, 1996-05, Vol.17 (3), p.215-218 |
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| subjects | Acetylcholinesterase - metabolism Animals Avoidance Learning - drug effects Biological and medical sciences Brain - metabolism Cholinesterase Inhibitors - pharmacology Female Male Medical sciences Memory - drug effects Mice Neuropharmacology Pharmacology. Drug treatments Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology Retention (Psychology) - drug effects Sesquiterpenes - pharmacology |
| title | Effects of suberogorgin and its derivates on learning and memory in mice |
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