Binding of 99Tcm sulphur colloid to blood components: implications in renal transplant rejection
The percentage binding of 99Tcm sulphur colloid to blood components (formed elements and plasma proteins) was studied within 1 min of the intravenous injection of the radiopharmaceutical in humans as well as rats. In humans, 68% of the total blood counts were bound to the formed elements (erythrocyt...
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| Veröffentlicht in: | Nuclear medicine communications 1988-11, Vol.9 (11), p.899-906 |
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| creator | Nadkarni, G D Shimpi, H H Noronha, O P |
| description | The percentage binding of 99Tcm sulphur colloid to blood components (formed elements and plasma proteins) was studied within 1 min of the intravenous injection of the radiopharmaceutical in humans as well as rats. In humans, 68% of the total blood counts were bound to the formed elements (erythrocytes, leucocytes and platelets). The binding pattern (as percentage of plasma counts) among the plasma protein fractions in humans was as follows: albumin, 9.85 +/- 2.06; fibrinogen, 56.70 +/- 7.96; and total proteins, 66.55 +/- 7.32. Activity bound to fibrinogen represented 82.3 +/- 9.1% of the total protein-bound activity in humans. In rats as well fibrinogen was the predominant binding protein (73.8 +/- 5.6). The significant binding of the 99Tcm sulphur colloid to plasma fibrinogen and formed elements of blood may be one of the reasons for the uptake of this radiocolloid in renal transplants before rejection. |
| doi_str_mv | 10.1097/00006231-198811000-00007 |
| format | Article |
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In humans, 68% of the total blood counts were bound to the formed elements (erythrocytes, leucocytes and platelets). The binding pattern (as percentage of plasma counts) among the plasma protein fractions in humans was as follows: albumin, 9.85 +/- 2.06; fibrinogen, 56.70 +/- 7.96; and total proteins, 66.55 +/- 7.32. Activity bound to fibrinogen represented 82.3 +/- 9.1% of the total protein-bound activity in humans. In rats as well fibrinogen was the predominant binding protein (73.8 +/- 5.6). 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In humans, 68% of the total blood counts were bound to the formed elements (erythrocytes, leucocytes and platelets). The binding pattern (as percentage of plasma counts) among the plasma protein fractions in humans was as follows: albumin, 9.85 +/- 2.06; fibrinogen, 56.70 +/- 7.96; and total proteins, 66.55 +/- 7.32. Activity bound to fibrinogen represented 82.3 +/- 9.1% of the total protein-bound activity in humans. In rats as well fibrinogen was the predominant binding protein (73.8 +/- 5.6). The significant binding of the 99Tcm sulphur colloid to plasma fibrinogen and formed elements of blood may be one of the reasons for the uptake of this radiocolloid in renal transplants before rejection.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Blood Platelets - metabolism</subject><subject>Erythrocytes - metabolism</subject><subject>Fibrinogen - metabolism</subject><subject>Graft Rejection</subject><subject>Kidney Transplantation</subject><subject>Leukocytes - metabolism</subject><subject>Male</subject><subject>Rats</subject><subject>Technetium Tc 99m Sulfur Colloid - blood</subject><issn>0143-3636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMlOwzAQhn0AlVJ4BCSfuAXsuPHCDSo2qRKXcg6OF3Dl2MFODrw9Li2dy8x8s-oHAGJ0g5Fgt6gYrQmusOAc45JVO8ROwBzhJakIJfQMnOe8LZQTymZgRhBrEKZz8PHggnbhE0YLhdioHubJD19Tgip6H52GY4Sdj1EX0A8xmDDmO-j6wTslRxdDhi7AZIL0cEwy5MHLMBawNWpXvgCnVvpsLg9-Ad6fHjerl2r99vy6ul9XCqOaVk3dWS6sWhLdYI3E0jaiM0vGO0x0Z2pdYomNNYhwaWjdaaIFttwaSZghhCzA9X7vkOL3ZPLY9i4r48s3Jk65ZZzRhghRGvm-UaWYczK2HZLrZfppMWp3grb_grZHQf8QK6NXhxtT1xt9HDyoSX4BMLx0eg</recordid><startdate>198811</startdate><enddate>198811</enddate><creator>Nadkarni, G D</creator><creator>Shimpi, H H</creator><creator>Noronha, O P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198811</creationdate><title>Binding of 99Tcm sulphur colloid to blood components: implications in renal transplant rejection</title><author>Nadkarni, G D ; Shimpi, H H ; Noronha, O P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1026-52bf89fc43d51d094f59be478b13dbe2de47a1efe038ae62bd3d91f8fea37e333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Binding Sites</topic><topic>Blood Platelets - metabolism</topic><topic>Erythrocytes - metabolism</topic><topic>Fibrinogen - metabolism</topic><topic>Graft Rejection</topic><topic>Kidney Transplantation</topic><topic>Leukocytes - metabolism</topic><topic>Male</topic><topic>Rats</topic><topic>Technetium Tc 99m Sulfur Colloid - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nadkarni, G D</creatorcontrib><creatorcontrib>Shimpi, H H</creatorcontrib><creatorcontrib>Noronha, O P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nuclear medicine communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nadkarni, G D</au><au>Shimpi, H H</au><au>Noronha, O P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of 99Tcm sulphur colloid to blood components: implications in renal transplant rejection</atitle><jtitle>Nuclear medicine communications</jtitle><addtitle>Nucl Med Commun</addtitle><date>1988-11</date><risdate>1988</risdate><volume>9</volume><issue>11</issue><spage>899</spage><epage>906</epage><pages>899-906</pages><issn>0143-3636</issn><abstract>The percentage binding of 99Tcm sulphur colloid to blood components (formed elements and plasma proteins) was studied within 1 min of the intravenous injection of the radiopharmaceutical in humans as well as rats. In humans, 68% of the total blood counts were bound to the formed elements (erythrocytes, leucocytes and platelets). The binding pattern (as percentage of plasma counts) among the plasma protein fractions in humans was as follows: albumin, 9.85 +/- 2.06; fibrinogen, 56.70 +/- 7.96; and total proteins, 66.55 +/- 7.32. Activity bound to fibrinogen represented 82.3 +/- 9.1% of the total protein-bound activity in humans. In rats as well fibrinogen was the predominant binding protein (73.8 +/- 5.6). The significant binding of the 99Tcm sulphur colloid to plasma fibrinogen and formed elements of blood may be one of the reasons for the uptake of this radiocolloid in renal transplants before rejection.</abstract><cop>England</cop><pmid>3075016</pmid><doi>10.1097/00006231-198811000-00007</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0143-3636 |
| ispartof | Nuclear medicine communications, 1988-11, Vol.9 (11), p.899-906 |
| issn | 0143-3636 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Binding Sites Blood Platelets - metabolism Erythrocytes - metabolism Fibrinogen - metabolism Graft Rejection Kidney Transplantation Leukocytes - metabolism Male Rats Technetium Tc 99m Sulfur Colloid - blood |
| title | Binding of 99Tcm sulphur colloid to blood components: implications in renal transplant rejection |
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