Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer
Epidemiological studies continue to identify an association of dietary antioxidant micronutrients in cancer prevention. A number of case-control and cohort studies have demonstrated a relationship between high intake of foods rich in carotenoids, tocopherols, and vitamin C with a reduced risk of cer...
Gespeichert in:
| Veröffentlicht in: | Clinical cancer research 1996-01, Vol.2 (1), p.181-185 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 185 |
|---|---|
| container_issue | 1 |
| container_start_page | 181 |
| container_title | Clinical cancer research |
| container_volume | 2 |
| creator | PALAN, P. R MIKHAIL, M. S GOLDBERG, G. L BASU, J RUNOWICZ, C. D ROMNEY, S. L |
| description | Epidemiological studies continue to identify an association of dietary antioxidant micronutrients in cancer prevention. A
number of case-control and cohort studies have demonstrated a relationship between high intake of foods rich in carotenoids,
tocopherols, and vitamin C with a reduced risk of certain human malignancies. The purpose of this study was to investigate
the comparative plasma levels of a profile of known dietary antioxidants, namely, beta-carotene, lycopene, canthaxanthin,
retinol, alpha-tocopherol, and tau-tocopherol. The target population was women with a histopathological diagnosis of cervical
intraepithelial neoplasia (CIN) or cervical cancer and a control group. All women resided in the same catchment area (Bronx
Borough, New York City) and were of similar inner-city socioeconomic backgrounds representing a fairly homogenous population
group. A cross-sectional sample of 235 women was recruited with informed consent. Plasma nutrient levels were measured by
reverse-phase high pressure liquid chromatography under study codes. The mean plasma levels of carotenoids (beta-carotene,
lycopene, and canthaxanthin), as well as alpha-tocopherol, were significantly lower in women with CIN and cervical cancer.
In contrast, the mean plasma level of tau-tocopherol was higher among patients with CIN, while the mean plasma level of retinol
was comparable among the groups. There were significant linear trends for all three carotenoids and quadratic trends for alpha-
and tau-tocopherol with the degree of cervical histopathology. Plasma beta-carotene concentrations in cigarette smokers were
significantly lower regardless of cervical pathology, whereas plasma lycopene and canthaxanthin levels were significantly
lower in smokers with CIN. The findings of a decrease in all plasma antioxidant nutrient levels except tau-tocopherol in women
with CIN and cancer suggest a potential role for antioxidant deficiency in the pathogenesis of CIN and carcinoma of the cervix,
which requires further investigation. |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_78765109</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78765109</sourcerecordid><originalsourceid>FETCH-LOGICAL-h266t-92f319cabb745e0853c5557f9d13f1c1b12682e81c10494fa5ae51b96bbfb7693</originalsourceid><addsrcrecordid>eNpNkMtOwzAQRSMEKlD4BCQvEKtGspPYSZao4iVVggWso7E7IUbOA9sp9C_4ZNw2Qmw8ZzR3HtdH0RnjPI_TRPDjwDQvYpqlyWl07twHpSxjNJtFs7JgglF-Fv28GHAtEIMbNI70NZHoIVZge48dLojZqn7Yk4LON_C9e3W3IBa97nqzINCtCZihgXiPHsbY96GpQdsbojui0G60gh17Czho36DRIe-wH8J6DfvGMD8oL6KTGozDyynOo7f7u9flY7x6fnha3q7iJhHCx2VSp6xUIGWecaQFTxUPxutyzdKaKSZZIooEi4A0K7MaOCBnshRS1jIXZTqPbg5zB9t_juh81Wqn0BgIV42uyotccEZ3wqtJOMoW19VgdQt2W01fGOrXUx1cMFnbYEO7P1lScsH5v32Nfm--tMXq4NeiQ7CqqZKKVaxg6S86yops</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78765109</pqid></control><display><type>article</type><title>Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer</title><source>MEDLINE</source><source>American Association for Cancer Research</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>PALAN, P. R ; MIKHAIL, M. S ; GOLDBERG, G. L ; BASU, J ; RUNOWICZ, C. D ; ROMNEY, S. L</creator><creatorcontrib>PALAN, P. R ; MIKHAIL, M. S ; GOLDBERG, G. L ; BASU, J ; RUNOWICZ, C. D ; ROMNEY, S. L</creatorcontrib><description>Epidemiological studies continue to identify an association of dietary antioxidant micronutrients in cancer prevention. A
number of case-control and cohort studies have demonstrated a relationship between high intake of foods rich in carotenoids,
tocopherols, and vitamin C with a reduced risk of certain human malignancies. The purpose of this study was to investigate
the comparative plasma levels of a profile of known dietary antioxidants, namely, beta-carotene, lycopene, canthaxanthin,
retinol, alpha-tocopherol, and tau-tocopherol. The target population was women with a histopathological diagnosis of cervical
intraepithelial neoplasia (CIN) or cervical cancer and a control group. All women resided in the same catchment area (Bronx
Borough, New York City) and were of similar inner-city socioeconomic backgrounds representing a fairly homogenous population
group. A cross-sectional sample of 235 women was recruited with informed consent. Plasma nutrient levels were measured by
reverse-phase high pressure liquid chromatography under study codes. The mean plasma levels of carotenoids (beta-carotene,
lycopene, and canthaxanthin), as well as alpha-tocopherol, were significantly lower in women with CIN and cervical cancer.
In contrast, the mean plasma level of tau-tocopherol was higher among patients with CIN, while the mean plasma level of retinol
was comparable among the groups. There were significant linear trends for all three carotenoids and quadratic trends for alpha-
and tau-tocopherol with the degree of cervical histopathology. Plasma beta-carotene concentrations in cigarette smokers were
significantly lower regardless of cervical pathology, whereas plasma lycopene and canthaxanthin levels were significantly
lower in smokers with CIN. The findings of a decrease in all plasma antioxidant nutrient levels except tau-tocopherol in women
with CIN and cancer suggest a potential role for antioxidant deficiency in the pathogenesis of CIN and carcinoma of the cervix,
which requires further investigation.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9816105</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Aged ; beta Carotene - blood ; Biological and medical sciences ; Canthaxanthin - blood ; Carotenoids - blood ; Cervical Intraepithelial Neoplasia - blood ; Cervical Intraepithelial Neoplasia - prevention & control ; Chromatography, High Pressure Liquid ; Cross-Sectional Studies ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Smoking - blood ; Tumors ; Uterine Cervical Neoplasms - blood ; Uterine Cervical Neoplasms - prevention & control ; Vitamin A - blood ; Vitamin E - blood</subject><ispartof>Clinical cancer research, 1996-01, Vol.2 (1), p.181-185</ispartof><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2956559$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9816105$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PALAN, P. R</creatorcontrib><creatorcontrib>MIKHAIL, M. S</creatorcontrib><creatorcontrib>GOLDBERG, G. L</creatorcontrib><creatorcontrib>BASU, J</creatorcontrib><creatorcontrib>RUNOWICZ, C. D</creatorcontrib><creatorcontrib>ROMNEY, S. L</creatorcontrib><title>Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>Epidemiological studies continue to identify an association of dietary antioxidant micronutrients in cancer prevention. A
number of case-control and cohort studies have demonstrated a relationship between high intake of foods rich in carotenoids,
tocopherols, and vitamin C with a reduced risk of certain human malignancies. The purpose of this study was to investigate
the comparative plasma levels of a profile of known dietary antioxidants, namely, beta-carotene, lycopene, canthaxanthin,
retinol, alpha-tocopherol, and tau-tocopherol. The target population was women with a histopathological diagnosis of cervical
intraepithelial neoplasia (CIN) or cervical cancer and a control group. All women resided in the same catchment area (Bronx
Borough, New York City) and were of similar inner-city socioeconomic backgrounds representing a fairly homogenous population
group. A cross-sectional sample of 235 women was recruited with informed consent. Plasma nutrient levels were measured by
reverse-phase high pressure liquid chromatography under study codes. The mean plasma levels of carotenoids (beta-carotene,
lycopene, and canthaxanthin), as well as alpha-tocopherol, were significantly lower in women with CIN and cervical cancer.
In contrast, the mean plasma level of tau-tocopherol was higher among patients with CIN, while the mean plasma level of retinol
was comparable among the groups. There were significant linear trends for all three carotenoids and quadratic trends for alpha-
and tau-tocopherol with the degree of cervical histopathology. Plasma beta-carotene concentrations in cigarette smokers were
significantly lower regardless of cervical pathology, whereas plasma lycopene and canthaxanthin levels were significantly
lower in smokers with CIN. The findings of a decrease in all plasma antioxidant nutrient levels except tau-tocopherol in women
with CIN and cancer suggest a potential role for antioxidant deficiency in the pathogenesis of CIN and carcinoma of the cervix,
which requires further investigation.</description><subject>Adult</subject><subject>Aged</subject><subject>beta Carotene - blood</subject><subject>Biological and medical sciences</subject><subject>Canthaxanthin - blood</subject><subject>Carotenoids - blood</subject><subject>Cervical Intraepithelial Neoplasia - blood</subject><subject>Cervical Intraepithelial Neoplasia - prevention & control</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Smoking - blood</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - blood</subject><subject>Uterine Cervical Neoplasms - prevention & control</subject><subject>Vitamin A - blood</subject><subject>Vitamin E - blood</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRSMEKlD4BCQvEKtGspPYSZao4iVVggWso7E7IUbOA9sp9C_4ZNw2Qmw8ZzR3HtdH0RnjPI_TRPDjwDQvYpqlyWl07twHpSxjNJtFs7JgglF-Fv28GHAtEIMbNI70NZHoIVZge48dLojZqn7Yk4LON_C9e3W3IBa97nqzINCtCZihgXiPHsbY96GpQdsbojui0G60gh17Czho36DRIe-wH8J6DfvGMD8oL6KTGozDyynOo7f7u9flY7x6fnha3q7iJhHCx2VSp6xUIGWecaQFTxUPxutyzdKaKSZZIooEi4A0K7MaOCBnshRS1jIXZTqPbg5zB9t_juh81Wqn0BgIV42uyotccEZ3wqtJOMoW19VgdQt2W01fGOrXUx1cMFnbYEO7P1lScsH5v32Nfm--tMXq4NeiQ7CqqZKKVaxg6S86yops</recordid><startdate>19960101</startdate><enddate>19960101</enddate><creator>PALAN, P. R</creator><creator>MIKHAIL, M. S</creator><creator>GOLDBERG, G. L</creator><creator>BASU, J</creator><creator>RUNOWICZ, C. D</creator><creator>ROMNEY, S. L</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19960101</creationdate><title>Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer</title><author>PALAN, P. R ; MIKHAIL, M. S ; GOLDBERG, G. L ; BASU, J ; RUNOWICZ, C. D ; ROMNEY, S. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-92f319cabb745e0853c5557f9d13f1c1b12682e81c10494fa5ae51b96bbfb7693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>beta Carotene - blood</topic><topic>Biological and medical sciences</topic><topic>Canthaxanthin - blood</topic><topic>Carotenoids - blood</topic><topic>Cervical Intraepithelial Neoplasia - blood</topic><topic>Cervical Intraepithelial Neoplasia - prevention & control</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Smoking - blood</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - blood</topic><topic>Uterine Cervical Neoplasms - prevention & control</topic><topic>Vitamin A - blood</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PALAN, P. R</creatorcontrib><creatorcontrib>MIKHAIL, M. S</creatorcontrib><creatorcontrib>GOLDBERG, G. L</creatorcontrib><creatorcontrib>BASU, J</creatorcontrib><creatorcontrib>RUNOWICZ, C. D</creatorcontrib><creatorcontrib>ROMNEY, S. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PALAN, P. R</au><au>MIKHAIL, M. S</au><au>GOLDBERG, G. L</au><au>BASU, J</au><au>RUNOWICZ, C. D</au><au>ROMNEY, S. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1996-01-01</date><risdate>1996</risdate><volume>2</volume><issue>1</issue><spage>181</spage><epage>185</epage><pages>181-185</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>Epidemiological studies continue to identify an association of dietary antioxidant micronutrients in cancer prevention. A
number of case-control and cohort studies have demonstrated a relationship between high intake of foods rich in carotenoids,
tocopherols, and vitamin C with a reduced risk of certain human malignancies. The purpose of this study was to investigate
the comparative plasma levels of a profile of known dietary antioxidants, namely, beta-carotene, lycopene, canthaxanthin,
retinol, alpha-tocopherol, and tau-tocopherol. The target population was women with a histopathological diagnosis of cervical
intraepithelial neoplasia (CIN) or cervical cancer and a control group. All women resided in the same catchment area (Bronx
Borough, New York City) and were of similar inner-city socioeconomic backgrounds representing a fairly homogenous population
group. A cross-sectional sample of 235 women was recruited with informed consent. Plasma nutrient levels were measured by
reverse-phase high pressure liquid chromatography under study codes. The mean plasma levels of carotenoids (beta-carotene,
lycopene, and canthaxanthin), as well as alpha-tocopherol, were significantly lower in women with CIN and cervical cancer.
In contrast, the mean plasma level of tau-tocopherol was higher among patients with CIN, while the mean plasma level of retinol
was comparable among the groups. There were significant linear trends for all three carotenoids and quadratic trends for alpha-
and tau-tocopherol with the degree of cervical histopathology. Plasma beta-carotene concentrations in cigarette smokers were
significantly lower regardless of cervical pathology, whereas plasma lycopene and canthaxanthin levels were significantly
lower in smokers with CIN. The findings of a decrease in all plasma antioxidant nutrient levels except tau-tocopherol in women
with CIN and cancer suggest a potential role for antioxidant deficiency in the pathogenesis of CIN and carcinoma of the cervix,
which requires further investigation.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9816105</pmid><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-0432 |
| ispartof | Clinical cancer research, 1996-01, Vol.2 (1), p.181-185 |
| issn | 1078-0432 1557-3265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78765109 |
| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Aged beta Carotene - blood Biological and medical sciences Canthaxanthin - blood Carotenoids - blood Cervical Intraepithelial Neoplasia - blood Cervical Intraepithelial Neoplasia - prevention & control Chromatography, High Pressure Liquid Cross-Sectional Studies Female Gynecology. Andrology. Obstetrics Humans Mammary gland diseases Medical sciences Middle Aged Smoking - blood Tumors Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - prevention & control Vitamin A - blood Vitamin E - blood |
| title | Plasma levels of beta-carotene, lycopene, canthaxanthin, retinol, and alpha- and tau-tocopherol in cervical intraepithelial neoplasia and cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T11%3A00%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20levels%20of%20beta-carotene,%20lycopene,%20canthaxanthin,%20retinol,%20and%20alpha-%20and%20tau-tocopherol%20in%20cervical%20intraepithelial%20neoplasia%20and%20cancer&rft.jtitle=Clinical%20cancer%20research&rft.au=PALAN,%20P.%20R&rft.date=1996-01-01&rft.volume=2&rft.issue=1&rft.spage=181&rft.epage=185&rft.pages=181-185&rft.issn=1078-0432&rft.eissn=1557-3265&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E78765109%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78765109&rft_id=info:pmid/9816105&rfr_iscdi=true |