Amorphous water-soluble cyclodextrin derivatives: 2-hydroxyethyl, 3-hydroxypropyl, 2-hydroxyisobutyl, and carboxamidomethyl derivatives of β-cyclodextrin

The pharmaceutical usefulness of natural, crystalline cyclodextrins can be improved by chemical conversions into water-soluble, amorphous mixtures of their derivatives. Reaction of beta-cyclodextrin with 2-chloroethanol, 3-chloropropanol, isobutylene oxide, or iodoacetamide yielded the title compoun...

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Veröffentlicht in:	Pharmaceutical research 1988-11, Vol.5 (11), p.713-717
Hauptverfasser:	IRIE, T, FUKUNAGA, K, YOSHIDA, A, UEKAMA, K, FALES, H. M, PITHA, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemical Phenomena Chemistry Cyclodextrins - analysis Dextrins - analysis General pharmacology Mass Spectrometry Medical sciences Molecular Conformation Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility Starch - analysis Water
Online-Zugang:	Volltext
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