Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots
From a dichloromethane extract of Newbouldia laevis roots, four new (6-hydroxydehydroiso-α-lapachone, 7-hydroxydehydroiso-α-lapachone, 5,7-dihydroxydehydroiso-α-lapachone and 3-hydroxy-5-methoxydehydroiso-α-lapachone) and six known naphthoquinones have been isolated. Their structures were establishe...
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| Veröffentlicht in: | Phytochemistry (Oxford) 1996-07, Vol.42 (5), p.1315-1320 |
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| container_title | Phytochemistry (Oxford) |
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| creator | Gafner, Stefan Wolfender, Jean-Luc Nianga, Malo Stoeckli-Evans, Helen Hostettmann, Kurt |
| description | From a dichloromethane extract of
Newbouldia laevis roots, four new (6-hydroxydehydroiso-α-lapachone, 7-hydroxydehydroiso-α-lapachone, 5,7-dihydroxydehydroiso-α-lapachone and 3-hydroxy-5-methoxydehydroiso-α-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry,
1H and
13C NMR) and that of 7-hydroxydehydroiso-α-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against
Cladosporium cucumerinum and
Candida albicans, and activity against the bacteria
Bacillus subtilis and
Escherichia coli. |
| doi_str_mv | 10.1016/0031-9422(96)00135-5 |
| format | Article |
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Newbouldia laevis roots, four new (6-hydroxydehydroiso-α-lapachone, 7-hydroxydehydroiso-α-lapachone, 5,7-dihydroxydehydroiso-α-lapachone and 3-hydroxy-5-methoxydehydroiso-α-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry,
1H and
13C NMR) and that of 7-hydroxydehydroiso-α-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against
Cladosporium cucumerinum and
Candida albicans, and activity against the bacteria
Bacillus subtilis and
Escherichia coli.</description><identifier>ISSN: 0031-9422</identifier><identifier>EISSN: 1873-3700</identifier><identifier>DOI: 10.1016/0031-9422(96)00135-5</identifier><identifier>PMID: 9397206</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Antifungal Agents - chemistry ; Antifungal Agents - isolation & purification ; Biological and medical sciences ; Biotechnology ; Chemical control ; Control ; Crystallography, X-Ray ; Fundamental and applied biological sciences. Psychology ; Fungal plant pathogens ; General pharmacology ; Medical sciences ; Naphthoquinones - chemistry ; Naphthoquinones - isolation & purification ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytopathology. Animal pests. Plant and forest protection ; Plants, Medicinal - chemistry ; Spectrum Analysis</subject><ispartof>Phytochemistry (Oxford), 1996-07, Vol.42 (5), p.1315-1320</ispartof><rights>1996</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-60051d5118ad40b05a3fa02f2347b929f8b187f73b510cea9b1f7b472d688f843</citedby><cites>FETCH-LOGICAL-c483t-60051d5118ad40b05a3fa02f2347b929f8b187f73b510cea9b1f7b472d688f843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0031-9422(96)00135-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3170629$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9397206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gafner, Stefan</creatorcontrib><creatorcontrib>Wolfender, Jean-Luc</creatorcontrib><creatorcontrib>Nianga, Malo</creatorcontrib><creatorcontrib>Stoeckli-Evans, Helen</creatorcontrib><creatorcontrib>Hostettmann, Kurt</creatorcontrib><title>Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots</title><title>Phytochemistry (Oxford)</title><addtitle>Phytochemistry</addtitle><description>From a dichloromethane extract of
Newbouldia laevis roots, four new (6-hydroxydehydroiso-α-lapachone, 7-hydroxydehydroiso-α-lapachone, 5,7-dihydroxydehydroiso-α-lapachone and 3-hydroxy-5-methoxydehydroiso-α-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry,
1H and
13C NMR) and that of 7-hydroxydehydroiso-α-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against
Cladosporium cucumerinum and
Candida albicans, and activity against the bacteria
Bacillus subtilis and
Escherichia coli.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Antifungal Agents - chemistry</subject><subject>Antifungal Agents - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Chemical control</subject><subject>Control</subject><subject>Crystallography, X-Ray</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal plant pathogens</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>Naphthoquinones - chemistry</subject><subject>Naphthoquinones - isolation & purification</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phytopathology. Animal pests. 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Newbouldia laevis roots, four new (6-hydroxydehydroiso-α-lapachone, 7-hydroxydehydroiso-α-lapachone, 5,7-dihydroxydehydroiso-α-lapachone and 3-hydroxy-5-methoxydehydroiso-α-lapachone) and six known naphthoquinones have been isolated. Their structures were established by spectroscopic methods (UV, EI mass spectrometry,
1H and
13C NMR) and that of 7-hydroxydehydroiso-α-lapachone was confirmed by X-ray crystallography. All naphthoquinones showed antifungal activity against
Cladosporium cucumerinum and
Candida albicans, and activity against the bacteria
Bacillus subtilis and
Escherichia coli.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>9397206</pmid><doi>10.1016/0031-9422(96)00135-5</doi><tpages>6</tpages></addata></record> |
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| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Antifungal Agents - chemistry Antifungal Agents - isolation & purification Biological and medical sciences Biotechnology Chemical control Control Crystallography, X-Ray Fundamental and applied biological sciences. Psychology Fungal plant pathogens General pharmacology Medical sciences Naphthoquinones - chemistry Naphthoquinones - isolation & purification Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phytopathology. Animal pests. Plant and forest protection Plants, Medicinal - chemistry Spectrum Analysis |
| title | Antifungal and antibacterial naphthoquinones from Newbouldia laevis roots |
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