Recombinant fowlpox virus inducing protective immunity in non-avian species

The natural host of fowlpox virus is limited to avian species. When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avia...

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Veröffentlicht in:Vaccine 1988-12, Vol.6 (6), p.497-503
Hauptverfasser: Taylor, Jill, Weinberg, Randall, Languet, Bernard, Desmettre, Philippe, Paoletti, Enzo
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container_end_page 503
container_issue 6
container_start_page 497
container_title Vaccine
container_volume 6
creator Taylor, Jill
Weinberg, Randall
Languet, Bernard
Desmettre, Philippe
Paoletti, Enzo
description The natural host of fowlpox virus is limited to avian species. When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avian (permissive) or non-avian (non-permissive) cells, the rabies glycoprotein was expressed as a membrane-associated antigen. Inoculation of the fowlpox virus recombinant into six different species of mammal resulted in specific immune responses to both fowlpox antigens and to rabies glycoprotein. In mice, cats and dogs the immune response was sufficient to protect against a live rabies virus challenge. The results demonstrate the utility of a fowlpox virus vector in immunizing non-avian species against rabies in the absence of productive viral replication of the fowlpox vector.
doi_str_mv 10.1016/0264-410X(88)90100-4
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source MEDLINE; ScienceDirect Journals (5 years ago - present)
subjects Animals
Antibody Formation
Biological and medical sciences
Cell Membrane
Fluorescent Antibody Technique
Fowlpox virus - genetics
Fundamental and applied biological sciences. Psychology
glycoprotein
Glycoproteins - genetics
immune response
Immunization
Microbiology
Poxviridae - genetics
Rabies
Rabies virus
recombinant DNA
Recombinant Proteins - genetics
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
vaccinia
Vertebrates
Virology
title Recombinant fowlpox virus inducing protective immunity in non-avian species
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