Recombinant fowlpox virus inducing protective immunity in non-avian species
The natural host of fowlpox virus is limited to avian species. When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avia...
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Veröffentlicht in: | Vaccine 1988-12, Vol.6 (6), p.497-503 |
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creator | Taylor, Jill Weinberg, Randall Languet, Bernard Desmettre, Philippe Paoletti, Enzo |
description | The natural host of fowlpox virus is limited to avian species. When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avian (permissive) or non-avian (non-permissive) cells, the rabies glycoprotein was expressed as a membrane-associated antigen. Inoculation of the fowlpox virus recombinant into six different species of mammal resulted in specific immune responses to both fowlpox antigens and to rabies glycoprotein. In mice, cats and dogs the immune response was sufficient to protect against a live rabies virus challenge. The results demonstrate the utility of a fowlpox virus vector in immunizing non-avian species against rabies in the absence of productive viral replication of the fowlpox vector. |
doi_str_mv | 10.1016/0264-410X(88)90100-4 |
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When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avian (permissive) or non-avian (non-permissive) cells, the rabies glycoprotein was expressed as a membrane-associated antigen. Inoculation of the fowlpox virus recombinant into six different species of mammal resulted in specific immune responses to both fowlpox antigens and to rabies glycoprotein. In mice, cats and dogs the immune response was sufficient to protect against a live rabies virus challenge. The results demonstrate the utility of a fowlpox virus vector in immunizing non-avian species against rabies in the absence of productive viral replication of the fowlpox vector.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/0264-410X(88)90100-4</identifier><identifier>PMID: 2854338</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Animals ; Antibody Formation ; Biological and medical sciences ; Cell Membrane ; Fluorescent Antibody Technique ; Fowlpox virus - genetics ; Fundamental and applied biological sciences. Psychology ; glycoprotein ; Glycoproteins - genetics ; immune response ; Immunization ; Microbiology ; Poxviridae - genetics ; Rabies ; Rabies virus ; recombinant DNA ; Recombinant Proteins - genetics ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; vaccinia ; Vertebrates ; Virology</subject><ispartof>Vaccine, 1988-12, Vol.6 (6), p.497-503</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468t-5f1fb7371aa51fcb7cf77a12950a45ffb46d0fb0874ebd7a07a74dd30fe3acf63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0264-410X(88)90100-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6763274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2854338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taylor, Jill</creatorcontrib><creatorcontrib>Weinberg, Randall</creatorcontrib><creatorcontrib>Languet, Bernard</creatorcontrib><creatorcontrib>Desmettre, Philippe</creatorcontrib><creatorcontrib>Paoletti, Enzo</creatorcontrib><title>Recombinant fowlpox virus inducing protective immunity in non-avian species</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The natural host of fowlpox virus is limited to avian species. When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avian (permissive) or non-avian (non-permissive) cells, the rabies glycoprotein was expressed as a membrane-associated antigen. Inoculation of the fowlpox virus recombinant into six different species of mammal resulted in specific immune responses to both fowlpox antigens and to rabies glycoprotein. In mice, cats and dogs the immune response was sufficient to protect against a live rabies virus challenge. The results demonstrate the utility of a fowlpox virus vector in immunizing non-avian species against rabies in the absence of productive viral replication of the fowlpox vector.</description><subject>Animals</subject><subject>Antibody Formation</subject><subject>Biological and medical sciences</subject><subject>Cell Membrane</subject><subject>Fluorescent Antibody Technique</subject><subject>Fowlpox virus - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>glycoprotein</subject><subject>Glycoproteins - genetics</subject><subject>immune response</subject><subject>Immunization</subject><subject>Microbiology</subject><subject>Poxviridae - genetics</subject><subject>Rabies</subject><subject>Rabies virus</subject><subject>recombinant DNA</subject><subject>Recombinant Proteins - genetics</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>vaccinia</subject><subject>Vertebrates</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMo4_j4BwpdiOiietMkTWYjyOALBwRRcBfSNJFIm45JOzr_3tYZZqmruzjfOVw-hI4wXGDA-SVkOU0phrczIc4ngAFSuoXGWHCSZgyLbTTeILtoL8YPAGAET0ZolAlGCRFj9PhsdFMXzivfJrb5qubNd7JwoYuJ82WnnX9P5qFpjW7dwiSurjvv2mUfJr7xqVo45ZM4N9qZeIB2rKqiOVzfffR6e_MyvU9nT3cP0-tZqmku2pRZbAtOOFaKYasLri3nCmcTBooyawual2ALEJyaouQKuOK0LAlYQ5S2OdlHp6vd_rHPzsRW1i5qU1XKm6aLkgvOKMXkXxCzjOQAA0hXoA5NjMFYOQ-uVmEpMchBthxMysGkFEL-ypa0rx2v97uiNuWmtLbb5yfrXEWtKhuU1y5usJznJOPDzNUKM720hTNBxl6n16Z0ofcuy8b9_ccPboycdQ</recordid><startdate>19881201</startdate><enddate>19881201</enddate><creator>Taylor, Jill</creator><creator>Weinberg, Randall</creator><creator>Languet, Bernard</creator><creator>Desmettre, Philippe</creator><creator>Paoletti, Enzo</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19881201</creationdate><title>Recombinant fowlpox virus inducing protective immunity in non-avian species</title><author>Taylor, Jill ; Weinberg, Randall ; Languet, Bernard ; Desmettre, Philippe ; Paoletti, Enzo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-5f1fb7371aa51fcb7cf77a12950a45ffb46d0fb0874ebd7a07a74dd30fe3acf63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Antibody Formation</topic><topic>Biological and medical sciences</topic><topic>Cell Membrane</topic><topic>Fluorescent Antibody Technique</topic><topic>Fowlpox virus - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>glycoprotein</topic><topic>Glycoproteins - genetics</topic><topic>immune response</topic><topic>Immunization</topic><topic>Microbiology</topic><topic>Poxviridae - genetics</topic><topic>Rabies</topic><topic>Rabies virus</topic><topic>recombinant DNA</topic><topic>Recombinant Proteins - genetics</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>vaccinia</topic><topic>Vertebrates</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taylor, Jill</creatorcontrib><creatorcontrib>Weinberg, Randall</creatorcontrib><creatorcontrib>Languet, Bernard</creatorcontrib><creatorcontrib>Desmettre, Philippe</creatorcontrib><creatorcontrib>Paoletti, Enzo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taylor, Jill</au><au>Weinberg, Randall</au><au>Languet, Bernard</au><au>Desmettre, Philippe</au><au>Paoletti, Enzo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombinant fowlpox virus inducing protective immunity in non-avian species</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1988-12-01</date><risdate>1988</risdate><volume>6</volume><issue>6</issue><spage>497</spage><epage>503</epage><pages>497-503</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The natural host of fowlpox virus is limited to avian species. When inoculated into non-avian tissue culture cells, however, fowlpox virus can initiate an abortive infection. A fowlpox virus was engineered to express rabies virus glycoprotein. On inoculation of the recombinant virus into either avian (permissive) or non-avian (non-permissive) cells, the rabies glycoprotein was expressed as a membrane-associated antigen. Inoculation of the fowlpox virus recombinant into six different species of mammal resulted in specific immune responses to both fowlpox antigens and to rabies glycoprotein. In mice, cats and dogs the immune response was sufficient to protect against a live rabies virus challenge. The results demonstrate the utility of a fowlpox virus vector in immunizing non-avian species against rabies in the absence of productive viral replication of the fowlpox vector.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>2854338</pmid><doi>10.1016/0264-410X(88)90100-4</doi><tpages>7</tpages></addata></record> |
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subjects | Animals Antibody Formation Biological and medical sciences Cell Membrane Fluorescent Antibody Technique Fowlpox virus - genetics Fundamental and applied biological sciences. Psychology glycoprotein Glycoproteins - genetics immune response Immunization Microbiology Poxviridae - genetics Rabies Rabies virus recombinant DNA Recombinant Proteins - genetics Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies vaccinia Vertebrates Virology |
title | Recombinant fowlpox virus inducing protective immunity in non-avian species |
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