Agonist-Induced Activation of Rat Mesenteric Resistance Vessels: Comparison Between Noradrenaline and Vasopressin
The effects of noradrenaline (NA, 10 M) and [arginine]vasopressin (AVP, 10 M) on tension in Ca -free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar–Kyoto (WKY) rats. The re...
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| Veröffentlicht in: | J. Cardiovasc. Pharmacol.; (United States) 1988, Vol.12 Suppl 5 (Supplement), p.128-133 |
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| container_title | J. Cardiovasc. Pharmacol.; (United States) |
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| creator | Cauvin, Cynthia Weir, Sheila W Wallnöfer, Andreas Rüegg, Urs |
| description | The effects of noradrenaline (NA, 10 M) and [arginine]vasopressin (AVP, 10 M) on tension in Ca -free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar–Kyoto (WKY) rats. The release of intracellular Ca by AVP contributed significantly less to its tension development than does that by NA. Nonetheless, the concentration-response curves for inhibition by isradipine of NA- and AVP-induced tonic tension were nearly identical. Similarly, these two agonists produced the same degree of membrane depolarization. In addition, both agonists were able to stimulate large contractions in vessels previously depolarized by 80 mM K. AVP also stimulated Ca influx into rat cultured aortic smooth muscle cells. In contrast to the stimulation of Ca influx by KCI depolarization, the agonist-stimulated Ca influx was insensitive to inhibition by organic Ca antagonists. It is concluded that Cap+ entry through receptor-operated Ca -permeable channels (ROCs) may contribute to agonist-induced activation of rat aortic and MRV smooth muscle. |
| doi_str_mv | 10.1097/00005344-198800125-00023 |
| format | Article |
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The release of intracellular Ca by AVP contributed significantly less to its tension development than does that by NA. Nonetheless, the concentration-response curves for inhibition by isradipine of NA- and AVP-induced tonic tension were nearly identical. Similarly, these two agonists produced the same degree of membrane depolarization. In addition, both agonists were able to stimulate large contractions in vessels previously depolarized by 80 mM K. AVP also stimulated Ca influx into rat cultured aortic smooth muscle cells. In contrast to the stimulation of Ca influx by KCI depolarization, the agonist-stimulated Ca influx was insensitive to inhibition by organic Ca antagonists. It is concluded that Cap+ entry through receptor-operated Ca -permeable channels (ROCs) may contribute to agonist-induced activation of rat aortic and MRV smooth muscle.</description><identifier>ISSN: 0160-2446</identifier><identifier>EISSN: 1533-4023</identifier><identifier>DOI: 10.1097/00005344-198800125-00023</identifier><identifier>PMID: 2469870</identifier><language>eng</language><publisher>United States: Lippincott-Raven Publishers</publisher><subject>550201 - Biochemistry- Tracer Techniques ; ADRENAL HORMONES ; ALKALINE EARTH ISOTOPES ; ALKALINE EARTH METAL COMPOUNDS ; ANIMALS ; Arginine Vasopressin - pharmacology ; AUTONOMIC NERVOUS SYSTEM AGENTS ; AZINES ; BASIC BIOLOGICAL SCIENCES ; BETA DECAY RADIOISOTOPES ; BETA-MINUS DECAY RADIOISOTOPES ; BIOCHEMICAL REACTION KINETICS ; Calcium - physiology ; CALCIUM 45 ; Calcium Channel Blockers - pharmacology ; CALCIUM COMPOUNDS ; CALCIUM ISOTOPES ; Calcium Radioisotopes ; CARDIOTONICS ; CARDIOVASCULAR AGENTS ; CELL CONSTITUENTS ; CELL CULTURES ; CELL MEMBRANES ; Cells, Cultured ; COMPARATIVE EVALUATIONS ; CONTRACTION ; DAYS LIVING RADIOISOTOPES ; DOSE-RESPONSE RELATIONSHIPS ; DRUGS ; EVEN-ODD NUCLEI ; HETEROCYCLIC COMPOUNDS ; HORMONES ; INTERMEDIATE MASS NUCLEI ; ISOTOPE APPLICATIONS ; ISOTOPES ; Isradipine ; KINETICS ; MAMMALS ; Membrane Potentials - drug effects ; MEMBRANE TRANSPORT ; MEMBRANES ; MUSCLES ; NEUROREGULATORS ; NORADRENALINE ; Norepinephrine - pharmacology ; NUCLEI ; ORGANIC COMPOUNDS ; ORGANIC NITROGEN COMPOUNDS ; PEPTIDE HORMONES ; PITUITARY HORMONES ; PYRIDINES ; Pyridines - pharmacology ; RADIOISOTOPES ; RATS ; Rats, Inbred WKY ; REACTION KINETICS ; RODENTS ; Splanchnic Circulation - drug effects ; SYMPATHOMIMETICS ; TRACER TECHNIQUES ; Vascular Resistance - drug effects ; VASOPRESSIN ; Vasopressins - pharmacology ; VERTEBRATES</subject><ispartof>J. Cardiovasc. Pharmacol.; (United States), 1988, Vol.12 Suppl 5 (Supplement), p.128-133</ispartof><rights>Lippincott-Raven Publishers.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00005344-198806125-00023$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>314,776,780,881,4010,4595,27902,27903,27904,65209</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2469870$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/5965165$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Cauvin, Cynthia</creatorcontrib><creatorcontrib>Weir, Sheila W</creatorcontrib><creatorcontrib>Wallnöfer, Andreas</creatorcontrib><creatorcontrib>Rüegg, Urs</creatorcontrib><creatorcontrib>Preclinical Research, Sandoz Ltd., Basel (Switzerland)</creatorcontrib><title>Agonist-Induced Activation of Rat Mesenteric Resistance Vessels: Comparison Between Noradrenaline and Vasopressin</title><title>J. Cardiovasc. Pharmacol.; (United States)</title><addtitle>J Cardiovasc Pharmacol</addtitle><description>The effects of noradrenaline (NA, 10 M) and [arginine]vasopressin (AVP, 10 M) on tension in Ca -free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar–Kyoto (WKY) rats. The release of intracellular Ca by AVP contributed significantly less to its tension development than does that by NA. Nonetheless, the concentration-response curves for inhibition by isradipine of NA- and AVP-induced tonic tension were nearly identical. Similarly, these two agonists produced the same degree of membrane depolarization. In addition, both agonists were able to stimulate large contractions in vessels previously depolarized by 80 mM K. AVP also stimulated Ca influx into rat cultured aortic smooth muscle cells. In contrast to the stimulation of Ca influx by KCI depolarization, the agonist-stimulated Ca influx was insensitive to inhibition by organic Ca antagonists. It is concluded that Cap+ entry through receptor-operated Ca -permeable channels (ROCs) may contribute to agonist-induced activation of rat aortic and MRV smooth muscle.</description><subject>550201 - Biochemistry- Tracer Techniques</subject><subject>ADRENAL HORMONES</subject><subject>ALKALINE EARTH ISOTOPES</subject><subject>ALKALINE EARTH METAL COMPOUNDS</subject><subject>ANIMALS</subject><subject>Arginine Vasopressin - pharmacology</subject><subject>AUTONOMIC NERVOUS SYSTEM AGENTS</subject><subject>AZINES</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>BETA DECAY RADIOISOTOPES</subject><subject>BETA-MINUS DECAY RADIOISOTOPES</subject><subject>BIOCHEMICAL REACTION KINETICS</subject><subject>Calcium - physiology</subject><subject>CALCIUM 45</subject><subject>Calcium Channel Blockers - pharmacology</subject><subject>CALCIUM COMPOUNDS</subject><subject>CALCIUM ISOTOPES</subject><subject>Calcium Radioisotopes</subject><subject>CARDIOTONICS</subject><subject>CARDIOVASCULAR AGENTS</subject><subject>CELL CONSTITUENTS</subject><subject>CELL CULTURES</subject><subject>CELL MEMBRANES</subject><subject>Cells, Cultured</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>CONTRACTION</subject><subject>DAYS LIVING RADIOISOTOPES</subject><subject>DOSE-RESPONSE RELATIONSHIPS</subject><subject>DRUGS</subject><subject>EVEN-ODD NUCLEI</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HORMONES</subject><subject>INTERMEDIATE MASS NUCLEI</subject><subject>ISOTOPE APPLICATIONS</subject><subject>ISOTOPES</subject><subject>Isradipine</subject><subject>KINETICS</subject><subject>MAMMALS</subject><subject>Membrane Potentials - drug effects</subject><subject>MEMBRANE TRANSPORT</subject><subject>MEMBRANES</subject><subject>MUSCLES</subject><subject>NEUROREGULATORS</subject><subject>NORADRENALINE</subject><subject>Norepinephrine - pharmacology</subject><subject>NUCLEI</subject><subject>ORGANIC COMPOUNDS</subject><subject>ORGANIC NITROGEN COMPOUNDS</subject><subject>PEPTIDE HORMONES</subject><subject>PITUITARY HORMONES</subject><subject>PYRIDINES</subject><subject>Pyridines - pharmacology</subject><subject>RADIOISOTOPES</subject><subject>RATS</subject><subject>Rats, Inbred WKY</subject><subject>REACTION KINETICS</subject><subject>RODENTS</subject><subject>Splanchnic Circulation - drug effects</subject><subject>SYMPATHOMIMETICS</subject><subject>TRACER TECHNIQUES</subject><subject>Vascular Resistance - drug effects</subject><subject>VASOPRESSIN</subject><subject>Vasopressins - pharmacology</subject><subject>VERTEBRATES</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkV1vFCEUhomxqWv1J5gQL7wbC8PHDN6tm6pNWk0a7S2hzBkXnYUth-nGfy-6203KDYTzvIdwHkIoZ-85M905q0sJKRtu-p4x3qqm3rTiGVlwJUQj6_k5WTCuWdNKqV-Ql4i_KihVp0_JaSu16Tu2IPfLnykGLM1lHGYPA136Eh5cCSnSNNIbV-g1IMQCOXh6A1hZFz3QW0CECT_QVdpsXQ5YAx-h7AAi_ZqyGzJEN4UI1MWB3jpM21wjIb4iJ6ObEF4f9jPy49PF99WX5urb58vV8qrxrTKiGbgZjTfgOuWYGDvnvW61ckZ5J-TIegFSAu_8wEExdle_qls2OvB-7GTPxBl5u--bsASLPhTwa59iBF-sMlpxrSr0bg9tc7qfAYvdBPQwTS5CmtF2fVfHbHgF-z3oc0LMMNptDhuX_1jO7D8l9lGJPSqx_5XU6JvDG_PdBoZj8OCg1uW-vktTHTP-nuYdZLsGN5W1fWpaH02Lv61ll30</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Cauvin, Cynthia</creator><creator>Weir, Sheila W</creator><creator>Wallnöfer, Andreas</creator><creator>Rüegg, Urs</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>1988</creationdate><title>Agonist-Induced Activation of Rat Mesenteric Resistance Vessels: Comparison Between Noradrenaline and Vasopressin</title><author>Cauvin, Cynthia ; Weir, Sheila W ; Wallnöfer, Andreas ; Rüegg, Urs</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2593-d19f9c9ea75a03f7acc6265a95ca34f083e44e17cd1e500b016620faeccf74803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>550201 - Biochemistry- Tracer Techniques</topic><topic>ADRENAL HORMONES</topic><topic>ALKALINE EARTH ISOTOPES</topic><topic>ALKALINE EARTH METAL COMPOUNDS</topic><topic>ANIMALS</topic><topic>Arginine Vasopressin - pharmacology</topic><topic>AUTONOMIC NERVOUS SYSTEM AGENTS</topic><topic>AZINES</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>BETA DECAY RADIOISOTOPES</topic><topic>BETA-MINUS DECAY RADIOISOTOPES</topic><topic>BIOCHEMICAL REACTION KINETICS</topic><topic>Calcium - physiology</topic><topic>CALCIUM 45</topic><topic>Calcium Channel Blockers - pharmacology</topic><topic>CALCIUM COMPOUNDS</topic><topic>CALCIUM ISOTOPES</topic><topic>Calcium Radioisotopes</topic><topic>CARDIOTONICS</topic><topic>CARDIOVASCULAR AGENTS</topic><topic>CELL CONSTITUENTS</topic><topic>CELL CULTURES</topic><topic>CELL MEMBRANES</topic><topic>Cells, Cultured</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>CONTRACTION</topic><topic>DAYS LIVING RADIOISOTOPES</topic><topic>DOSE-RESPONSE RELATIONSHIPS</topic><topic>DRUGS</topic><topic>EVEN-ODD NUCLEI</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HORMONES</topic><topic>INTERMEDIATE MASS NUCLEI</topic><topic>ISOTOPE APPLICATIONS</topic><topic>ISOTOPES</topic><topic>Isradipine</topic><topic>KINETICS</topic><topic>MAMMALS</topic><topic>Membrane Potentials - drug effects</topic><topic>MEMBRANE TRANSPORT</topic><topic>MEMBRANES</topic><topic>MUSCLES</topic><topic>NEUROREGULATORS</topic><topic>NORADRENALINE</topic><topic>Norepinephrine - pharmacology</topic><topic>NUCLEI</topic><topic>ORGANIC COMPOUNDS</topic><topic>ORGANIC NITROGEN COMPOUNDS</topic><topic>PEPTIDE HORMONES</topic><topic>PITUITARY HORMONES</topic><topic>PYRIDINES</topic><topic>Pyridines - pharmacology</topic><topic>RADIOISOTOPES</topic><topic>RATS</topic><topic>Rats, Inbred WKY</topic><topic>REACTION KINETICS</topic><topic>RODENTS</topic><topic>Splanchnic Circulation - drug effects</topic><topic>SYMPATHOMIMETICS</topic><topic>TRACER TECHNIQUES</topic><topic>Vascular Resistance - drug effects</topic><topic>VASOPRESSIN</topic><topic>Vasopressins - pharmacology</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cauvin, Cynthia</creatorcontrib><creatorcontrib>Weir, Sheila W</creatorcontrib><creatorcontrib>Wallnöfer, Andreas</creatorcontrib><creatorcontrib>Rüegg, Urs</creatorcontrib><creatorcontrib>Preclinical Research, Sandoz Ltd., Basel (Switzerland)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>J. Cardiovasc. Pharmacol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cauvin, Cynthia</au><au>Weir, Sheila W</au><au>Wallnöfer, Andreas</au><au>Rüegg, Urs</au><aucorp>Preclinical Research, Sandoz Ltd., Basel (Switzerland)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Agonist-Induced Activation of Rat Mesenteric Resistance Vessels: Comparison Between Noradrenaline and Vasopressin</atitle><jtitle>J. Cardiovasc. Pharmacol.; (United States)</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1988</date><risdate>1988</risdate><volume>12 Suppl 5</volume><issue>Supplement</issue><spage>128</spage><epage>133</epage><pages>128-133</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>The effects of noradrenaline (NA, 10 M) and [arginine]vasopressin (AVP, 10 M) on tension in Ca -free medium and on membrane potential, and the inhibition of NA- and AVP-induced contractions by isradipine, have been compared in mesenteric resistance vessels (MRVs) from Wistar–Kyoto (WKY) rats. The release of intracellular Ca by AVP contributed significantly less to its tension development than does that by NA. Nonetheless, the concentration-response curves for inhibition by isradipine of NA- and AVP-induced tonic tension were nearly identical. Similarly, these two agonists produced the same degree of membrane depolarization. In addition, both agonists were able to stimulate large contractions in vessels previously depolarized by 80 mM K. AVP also stimulated Ca influx into rat cultured aortic smooth muscle cells. In contrast to the stimulation of Ca influx by KCI depolarization, the agonist-stimulated Ca influx was insensitive to inhibition by organic Ca antagonists. It is concluded that Cap+ entry through receptor-operated Ca -permeable channels (ROCs) may contribute to agonist-induced activation of rat aortic and MRV smooth muscle.</abstract><cop>United States</cop><pub>Lippincott-Raven Publishers</pub><pmid>2469870</pmid><doi>10.1097/00005344-198800125-00023</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0160-2446 |
| ispartof | J. Cardiovasc. Pharmacol.; (United States), 1988, Vol.12 Suppl 5 (Supplement), p.128-133 |
| issn | 0160-2446 1533-4023 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78753491 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete |
| subjects | 550201 - Biochemistry- Tracer Techniques ADRENAL HORMONES ALKALINE EARTH ISOTOPES ALKALINE EARTH METAL COMPOUNDS ANIMALS Arginine Vasopressin - pharmacology AUTONOMIC NERVOUS SYSTEM AGENTS AZINES BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES BIOCHEMICAL REACTION KINETICS Calcium - physiology CALCIUM 45 Calcium Channel Blockers - pharmacology CALCIUM COMPOUNDS CALCIUM ISOTOPES Calcium Radioisotopes CARDIOTONICS CARDIOVASCULAR AGENTS CELL CONSTITUENTS CELL CULTURES CELL MEMBRANES Cells, Cultured COMPARATIVE EVALUATIONS CONTRACTION DAYS LIVING RADIOISOTOPES DOSE-RESPONSE RELATIONSHIPS DRUGS EVEN-ODD NUCLEI HETEROCYCLIC COMPOUNDS HORMONES INTERMEDIATE MASS NUCLEI ISOTOPE APPLICATIONS ISOTOPES Isradipine KINETICS MAMMALS Membrane Potentials - drug effects MEMBRANE TRANSPORT MEMBRANES MUSCLES NEUROREGULATORS NORADRENALINE Norepinephrine - pharmacology NUCLEI ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS PEPTIDE HORMONES PITUITARY HORMONES PYRIDINES Pyridines - pharmacology RADIOISOTOPES RATS Rats, Inbred WKY REACTION KINETICS RODENTS Splanchnic Circulation - drug effects SYMPATHOMIMETICS TRACER TECHNIQUES Vascular Resistance - drug effects VASOPRESSIN Vasopressins - pharmacology VERTEBRATES |
| title | Agonist-Induced Activation of Rat Mesenteric Resistance Vessels: Comparison Between Noradrenaline and Vasopressin |
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