Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct Dementia patients
The binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) to platelets was studied in 22 patients with probable Alzheimer's disease (AD), 11 with multi-infarct dementia (MID), 22 age-matched normal old controls, and 20 young subjects. The results showed a s...
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| Veröffentlicht in: | Neurobiology of aging 1996-11, Vol.17 (6), p.865-868 |
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| creator | Hershkowitz, Moshe Adunsky, Abraham |
| description | The binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) to platelets was studied in 22 patients with probable Alzheimer's disease (AD), 11 with multi-infarct dementia (MID), 22 age-matched normal old controls, and 20 young subjects. The results showed a significantly lower degree of PAF binding to platelets of AD and MID patients than in those of the old controls and young subjects (133.3 ± 8.5, and 123.4 ± 16.5 vs. 202.3 ± 11.6 and 206.7 ± 17.3 receptors/cell, respectively;
p < 0.01). These differences were due to reduced
B
max, while
K
d remained unchanged. No significant difference was observed between the PAF binding to platelets of AD and MID patients nor between that of old and young controls. No correlation was found between age and binding in the various elderly groups. However, a significant correlation was found between PAF binding and degree of cognitive impairment in the AD patients. This is the first evidence to support a possible involvement of PAF in dementing disorders. |
| doi_str_mv | 10.1016/S0197-4580(96)00073-5 |
| format | Article |
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p < 0.01). These differences were due to reduced
B
max, while
K
d remained unchanged. No significant difference was observed between the PAF binding to platelets of AD and MID patients nor between that of old and young controls. No correlation was found between age and binding in the various elderly groups. However, a significant correlation was found between PAF binding and degree of cognitive impairment in the AD patients. This is the first evidence to support a possible involvement of PAF in dementing disorders.</description><identifier>ISSN: 0197-4580</identifier><identifier>EISSN: 1558-1497</identifier><identifier>DOI: 10.1016/S0197-4580(96)00073-5</identifier><identifier>PMID: 9363797</identifier><identifier>CODEN: NEAGDO</identifier><language>eng</language><publisher>London: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Aging ; Alzheimer ; Alzheimer Disease - blood ; Alzheimer Disease - metabolism ; Alzheimer Disease - psychology ; Binding ; Biological and medical sciences ; Blood Platelets - metabolism ; Cerebrovascular disease ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dementia, Multi-Infarct - blood ; Dementia, Multi-Infarct - metabolism ; Dementia, Multi-Infarct - psychology ; Female ; Humans ; Kinetics ; Male ; Medical sciences ; Middle Aged ; Neurobehavioral Manifestations ; Neurology ; Platelet Activating Factor - metabolism ; Platelet Membrane Glycoproteins - metabolism ; Platelet-activating factor ; Platelets ; Receptors, Cell Surface ; Receptors, G-Protein-Coupled ; Sex Characteristics</subject><ispartof>Neurobiology of aging, 1996-11, Vol.17 (6), p.865-868</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-2be591ddc0ae4c9faa7b36bc6754621451e0293864e5409a5ef61132e1fc25713</citedby><cites>FETCH-LOGICAL-c472t-2be591ddc0ae4c9faa7b36bc6754621451e0293864e5409a5ef61132e1fc25713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0197-4580(96)00073-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3541,27915,27916,45986</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2516201$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9363797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hershkowitz, Moshe</creatorcontrib><creatorcontrib>Adunsky, Abraham</creatorcontrib><title>Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct Dementia patients</title><title>Neurobiology of aging</title><addtitle>Neurobiol Aging</addtitle><description>The binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) to platelets was studied in 22 patients with probable Alzheimer's disease (AD), 11 with multi-infarct dementia (MID), 22 age-matched normal old controls, and 20 young subjects. The results showed a significantly lower degree of PAF binding to platelets of AD and MID patients than in those of the old controls and young subjects (133.3 ± 8.5, and 123.4 ± 16.5 vs. 202.3 ± 11.6 and 206.7 ± 17.3 receptors/cell, respectively;
p < 0.01). These differences were due to reduced
B
max, while
K
d remained unchanged. No significant difference was observed between the PAF binding to platelets of AD and MID patients nor between that of old and young controls. No correlation was found between age and binding in the various elderly groups. However, a significant correlation was found between PAF binding and degree of cognitive impairment in the AD patients. This is the first evidence to support a possible involvement of PAF in dementing disorders.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Alzheimer</subject><subject>Alzheimer Disease - blood</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer Disease - psychology</subject><subject>Binding</subject><subject>Biological and medical sciences</subject><subject>Blood Platelets - metabolism</subject><subject>Cerebrovascular disease</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dementia, Multi-Infarct - blood</subject><subject>Dementia, Multi-Infarct - metabolism</subject><subject>Dementia, Multi-Infarct - psychology</subject><subject>Female</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurobehavioral Manifestations</subject><subject>Neurology</subject><subject>Platelet Activating Factor - metabolism</subject><subject>Platelet Membrane Glycoproteins - metabolism</subject><subject>Platelet-activating factor</subject><subject>Platelets</subject><subject>Receptors, Cell Surface</subject><subject>Receptors, G-Protein-Coupled</subject><subject>Sex Characteristics</subject><issn>0197-4580</issn><issn>1558-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EKkvhJ1TKAfFxCHgcf6xPVSm0VKrEAThbs84YjJxksb2Vyq8n6a722pNHfp-Zsd-XsTPgH4CD_vidgzWtVGv-zur3nHPTteoJW4FS6xakNU_Z6og8Zy9K-bNA0ugTdmI73RlrVix9imMfx1_NFJptwkqJaou-xjusy3WY6yk3dTqqZUEv0r_fFAfKb0vTx0JYqMGxb4ZdqjGOAbOvzWcaaKwRm-08a67KS_YsYCr06nCesp9XX35cfm1vv13fXF7ctl4aUVuxIWWh7z1Hkt4GRLPp9MZro6QWIBUQF7Zba0lKcouKggboBEHwQhnoTtmb_dxtnv7uqFQ3xOIpJRxp2hVn1kYJocWjICirtAY-g2oP-jyVkim4bY4D5nsH3C1xuIc43OK1s9o9xOHU3Hd2WLDbDNQfuw7-z_rrg47FYwoZRx_LERMKtODLh873GM2u3UXKrvjZUU99zOSr66f4yEP-A_77p2s</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Hershkowitz, Moshe</creator><creator>Adunsky, Abraham</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19961101</creationdate><title>Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct Dementia patients</title><author>Hershkowitz, Moshe ; Adunsky, Abraham</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-2be591ddc0ae4c9faa7b36bc6754621451e0293864e5409a5ef61132e1fc25713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Alzheimer</topic><topic>Alzheimer Disease - blood</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer Disease - psychology</topic><topic>Binding</topic><topic>Biological and medical sciences</topic><topic>Blood Platelets - metabolism</topic><topic>Cerebrovascular disease</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Dementia, Multi-Infarct - blood</topic><topic>Dementia, Multi-Infarct - metabolism</topic><topic>Dementia, Multi-Infarct - psychology</topic><topic>Female</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurobehavioral Manifestations</topic><topic>Neurology</topic><topic>Platelet Activating Factor - metabolism</topic><topic>Platelet Membrane Glycoproteins - metabolism</topic><topic>Platelet-activating factor</topic><topic>Platelets</topic><topic>Receptors, Cell Surface</topic><topic>Receptors, G-Protein-Coupled</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hershkowitz, Moshe</creatorcontrib><creatorcontrib>Adunsky, Abraham</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neurobiology of aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hershkowitz, Moshe</au><au>Adunsky, Abraham</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct Dementia patients</atitle><jtitle>Neurobiology of aging</jtitle><addtitle>Neurobiol Aging</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>17</volume><issue>6</issue><spage>865</spage><epage>868</epage><pages>865-868</pages><issn>0197-4580</issn><eissn>1558-1497</eissn><coden>NEAGDO</coden><abstract>The binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor, PAF) to platelets was studied in 22 patients with probable Alzheimer's disease (AD), 11 with multi-infarct dementia (MID), 22 age-matched normal old controls, and 20 young subjects. The results showed a significantly lower degree of PAF binding to platelets of AD and MID patients than in those of the old controls and young subjects (133.3 ± 8.5, and 123.4 ± 16.5 vs. 202.3 ± 11.6 and 206.7 ± 17.3 receptors/cell, respectively;
p < 0.01). These differences were due to reduced
B
max, while
K
d remained unchanged. No significant difference was observed between the PAF binding to platelets of AD and MID patients nor between that of old and young controls. No correlation was found between age and binding in the various elderly groups. However, a significant correlation was found between PAF binding and degree of cognitive impairment in the AD patients. This is the first evidence to support a possible involvement of PAF in dementing disorders.</abstract><cop>London</cop><pub>Elsevier Inc</pub><pmid>9363797</pmid><doi>10.1016/S0197-4580(96)00073-5</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Aging Alzheimer Alzheimer Disease - blood Alzheimer Disease - metabolism Alzheimer Disease - psychology Binding Biological and medical sciences Blood Platelets - metabolism Cerebrovascular disease Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dementia, Multi-Infarct - blood Dementia, Multi-Infarct - metabolism Dementia, Multi-Infarct - psychology Female Humans Kinetics Male Medical sciences Middle Aged Neurobehavioral Manifestations Neurology Platelet Activating Factor - metabolism Platelet Membrane Glycoproteins - metabolism Platelet-activating factor Platelets Receptors, Cell Surface Receptors, G-Protein-Coupled Sex Characteristics |
| title | Binding of platelet-activating factor to platelets of Alzheimer's disease and multiinfarct Dementia patients |
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