Vitamin D and pancreatic islet function. II. Dynamics of insulin release and cationic fluxes
Pancreatic islets were prepared from control and vitamin D-deprived rats 2 or 5 weeks after weaning and, in the latter case, after 3 or 6 days treatment with exogenous vitamin D3 (60 nmol per day). The islets were prelabelled with both 86Rb and 45Ca and placed in a perfusion chamber. Vitamin D depri...
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Veröffentlicht in: | Journal of endocrinological investigation 1988-09, Vol.11 (8), p.585-593 |
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creator | Billaudel, B Labriji-Mestaghanmi, H Sutter, B C Malaisse, W J |
description | Pancreatic islets were prepared from control and vitamin D-deprived rats 2 or 5 weeks after weaning and, in the latter case, after 3 or 6 days treatment with exogenous vitamin D3 (60 nmol per day). The islets were prelabelled with both 86Rb and 45Ca and placed in a perfusion chamber. Vitamin D deprivation or administration failed to affect 86Rb outflow whether prior or after stimulation of the islets by a rise in either extracellular D-glucose or Ca2+ concentration. However, vitamin D deprivation decreased and vitamin D administration enhanced the basal 45Ca fractional outflow rate, as well as the magnitude of changes in both 45Ca and insulin release evoked by the rise in either D-glucose or extracellular Ca2+. It is proposed that the alteration in 45Ca fluxes and insulin release attributable to changes in the supply of vitamin D are, to a large extent, independent of the changes in nutrient catabolism conceivably associated with vitamin D deprivation and administration. |
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Dynamics of insulin release and cationic fluxes</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Billaudel, B ; Labriji-Mestaghanmi, H ; Sutter, B C ; Malaisse, W J</creator><creatorcontrib>Billaudel, B ; Labriji-Mestaghanmi, H ; Sutter, B C ; Malaisse, W J</creatorcontrib><description>Pancreatic islets were prepared from control and vitamin D-deprived rats 2 or 5 weeks after weaning and, in the latter case, after 3 or 6 days treatment with exogenous vitamin D3 (60 nmol per day). The islets were prelabelled with both 86Rb and 45Ca and placed in a perfusion chamber. Vitamin D deprivation or administration failed to affect 86Rb outflow whether prior or after stimulation of the islets by a rise in either extracellular D-glucose or Ca2+ concentration. However, vitamin D deprivation decreased and vitamin D administration enhanced the basal 45Ca fractional outflow rate, as well as the magnitude of changes in both 45Ca and insulin release evoked by the rise in either D-glucose or extracellular Ca2+. It is proposed that the alteration in 45Ca fluxes and insulin release attributable to changes in the supply of vitamin D are, to a large extent, independent of the changes in nutrient catabolism conceivably associated with vitamin D deprivation and administration.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.1007/BF03350186</identifier><identifier>PMID: 3072374</identifier><language>eng</language><publisher>Italy</publisher><subject>Animals ; Calcium - pharmacokinetics ; Calcium - pharmacology ; Cations - pharmacokinetics ; Glucose - pharmacology ; Insulin - metabolism ; Insulin Secretion ; Islets of Langerhans - drug effects ; Islets of Langerhans - physiology ; Rats ; Rubidium - pharmacokinetics ; Rubidium - pharmacology ; Vitamin D - pharmacology</subject><ispartof>Journal of endocrinological investigation, 1988-09, Vol.11 (8), p.585-593</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c228t-80aedeedbfff89aedfd6dcafd08d8dfb19159bc9235dafac48142187ac01cb913</citedby><cites>FETCH-LOGICAL-c228t-80aedeedbfff89aedfd6dcafd08d8dfb19159bc9235dafac48142187ac01cb913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3072374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Billaudel, B</creatorcontrib><creatorcontrib>Labriji-Mestaghanmi, H</creatorcontrib><creatorcontrib>Sutter, B C</creatorcontrib><creatorcontrib>Malaisse, W J</creatorcontrib><title>Vitamin D and pancreatic islet function. II. Dynamics of insulin release and cationic fluxes</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><description>Pancreatic islets were prepared from control and vitamin D-deprived rats 2 or 5 weeks after weaning and, in the latter case, after 3 or 6 days treatment with exogenous vitamin D3 (60 nmol per day). The islets were prelabelled with both 86Rb and 45Ca and placed in a perfusion chamber. Vitamin D deprivation or administration failed to affect 86Rb outflow whether prior or after stimulation of the islets by a rise in either extracellular D-glucose or Ca2+ concentration. However, vitamin D deprivation decreased and vitamin D administration enhanced the basal 45Ca fractional outflow rate, as well as the magnitude of changes in both 45Ca and insulin release evoked by the rise in either D-glucose or extracellular Ca2+. It is proposed that the alteration in 45Ca fluxes and insulin release attributable to changes in the supply of vitamin D are, to a large extent, independent of the changes in nutrient catabolism conceivably associated with vitamin D deprivation and administration.</description><subject>Animals</subject><subject>Calcium - pharmacokinetics</subject><subject>Calcium - pharmacology</subject><subject>Cations - pharmacokinetics</subject><subject>Glucose - pharmacology</subject><subject>Insulin - metabolism</subject><subject>Insulin Secretion</subject><subject>Islets of Langerhans - drug effects</subject><subject>Islets of Langerhans - physiology</subject><subject>Rats</subject><subject>Rubidium - pharmacokinetics</subject><subject>Rubidium - pharmacology</subject><subject>Vitamin D - pharmacology</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EKqWwsCN5YkBK8SOJ7RFaCpEqsQATUuTY15JR4pQ4kei_J6UVjEz3Dud8w0HokpI5JUTc3q8I5xmhMj9CUyoYSSSX-TGaEq5okhIlTtFZjB-EcMGlmKAJJ4JxkU7R-5vvdeMDXmIdLN7oYDrQvTfYxxp67IZget-GOS6KOV5uwwibiFuHfYhDPYod1KAj_OhG79hRdvXwBfEcnThdR7g43Bl6XT28LJ6S9fNjsbhbJ4Yx2SeSaLAAtnLOSTX-zubWaGeJtNK6iiqaqcooxjOrnTappCmjUmhDqKkU5TN0vd_ddO3nALEvGx8N1LUO0A6xFFKkmcrzf0GaMab4GGmGbvag6doYO3DlpvON7rYlJeWuefnXfISvDqtD1YD9RQ-R-Tc6m3zh</recordid><startdate>198809</startdate><enddate>198809</enddate><creator>Billaudel, B</creator><creator>Labriji-Mestaghanmi, H</creator><creator>Sutter, B C</creator><creator>Malaisse, W J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>198809</creationdate><title>Vitamin D and pancreatic islet function. 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subjects | Animals Calcium - pharmacokinetics Calcium - pharmacology Cations - pharmacokinetics Glucose - pharmacology Insulin - metabolism Insulin Secretion Islets of Langerhans - drug effects Islets of Langerhans - physiology Rats Rubidium - pharmacokinetics Rubidium - pharmacology Vitamin D - pharmacology |
title | Vitamin D and pancreatic islet function. II. Dynamics of insulin release and cationic fluxes |
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