Identification of a translation inhibitory element (TIE) in the 3′ untranslated region of the human interferon-β mRNA

We have previously reported that the 3' untranslated region (UTR) of the human interferon-β mRNA has an inhibitory effect on the mRNA translation both in vitro, in a rabbit reticulocyte lysate, and in vivo, in the Xenopus oocyte. In the present study, we identify the sequence in the 3' UTR...

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Veröffentlicht in:	Gene 1988-12, Vol.72 (1), p.191-200
Hauptverfasser:	Kruys, Véronique I., Wathelet, Marc G., Huez, Georges A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Humans inflammatory response Interferon Type I - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data mRNA stability Oocytes - metabolism Plasmids Protein Biosynthesis Rabbits Recombinant DNA Reticulocytes - metabolism RNA, Messenger - genetics SP6 RNA transcripts Transcription, Genetic Translation. Translation factors. Protein processing translational efficiency Xenopus
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