Serotonergic Blockade Compared with Beta-Adrenergic Blockade in Systemic Hypertension: A Double-Blind Comparison of Ketanserin with Propranolol
The safety and efficacy of ketanserin, a competitive serotonin blocking agent, and Propranolol were compared in 33 patients with mild to moderate hypertension (sitting diastolic blood pressure {DBP} 95–115 mm Hg) using a placebo run‐in, randomized, double‐blind, parallel study design. All patients r...
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| Veröffentlicht in: | Journal of clinical pharmacology 1988-11, Vol.28 (11), p.1008-1016 |
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| container_title | Journal of clinical pharmacology |
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| creator | Okin, Stuart Huberfeld, Seymour I. Frishman, William H. Soberman, Judith Laifer, Larry Greenberg, Steven Lapsker, Jeanne Charlap, Shlomo Strom, Joel A. |
| description | The safety and efficacy of ketanserin, a competitive serotonin blocking agent, and Propranolol were compared in 33 patients with mild to moderate hypertension (sitting diastolic blood pressure {DBP} 95–115 mm Hg) using a placebo run‐in, randomized, double‐blind, parallel study design. All patients received placebo for 4 weeks, then were randomized to receive increasing doses of either ketanerin (20, 40 mg twice daily) or propranolol (40, 80 mg twice daily) to achieve a goal sitting DBP |
| doi_str_mv | 10.1002/j.1552-4604.1988.tb03122.x |
| format | Article |
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All patients received placebo for 4 weeks, then were randomized to receive increasing doses of either ketanerin (20, 40 mg twice daily) or propranolol (40, 80 mg twice daily) to achieve a goal sitting DBP <90 mm Hg. Patients not achieving the goal blood pressure with either drug as monotherapy, received the other drug in combination. At the end of the active monotherapy phase (week 10 of the study), propranolol demonstrated a greater decrease in DBP from baseline, as compared to ketanserin (−7.9 ± 10.9 mm Hg with propranolol, P < 0.05; —1.0 ± 7.2 mm Hg with ketanserin, P = NS). Four out of 16 patients achieved goal response on propranolol, compared to 3/17 for ketanserin. With combination treatment, 9/18 patients reached the goal response; the addition of propranolol to ketanserin in non‐responders resulted in further reduction of sitting DBP of −10.3 ± 6.3 compared to monotherapy (P < 0.001), while the addition of ketanserin to non‐responders produced no significant response in sitting DBP. Propranolol showed a consistent effect in slowing heart rate. Ketanserin displayed less frequent side effects than propranolol. Propranolol used twice daily appears to be more effective than twice daily ketanserin use in patients with mild to moderate hypertension.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1988.tb03122.x</identifier><identifier>PMID: 2907519</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Adult ; Bleeding Time ; Blood Platelets - drug effects ; Blood Pressure - drug effects ; Double-Blind Method ; Electrocardiography ; Female ; Heart Rate - drug effects ; Humans ; Hypertension - drug therapy ; Hypertension - physiopathology ; Ketanserin - blood ; Ketanserin - pharmacokinetics ; Ketanserin - therapeutic use ; Male ; Middle Aged ; Propranolol - blood ; Propranolol - pharmacokinetics ; Propranolol - therapeutic use ; Random Allocation ; Serotonin Antagonists - therapeutic use</subject><ispartof>Journal of clinical pharmacology, 1988-11, Vol.28 (11), p.1008-1016</ispartof><rights>1988 American College of Clinical Pharmacology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4092-f7de94623afbb276e2b0b321c1bfc23ef0b4c299e36e14d203a2fbd5e97834083</citedby><cites>FETCH-LOGICAL-c4092-f7de94623afbb276e2b0b321c1bfc23ef0b4c299e36e14d203a2fbd5e97834083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fj.1552-4604.1988.tb03122.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fj.1552-4604.1988.tb03122.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2907519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okin, Stuart</creatorcontrib><creatorcontrib>Huberfeld, Seymour I.</creatorcontrib><creatorcontrib>Frishman, William H.</creatorcontrib><creatorcontrib>Soberman, Judith</creatorcontrib><creatorcontrib>Laifer, Larry</creatorcontrib><creatorcontrib>Greenberg, Steven</creatorcontrib><creatorcontrib>Lapsker, Jeanne</creatorcontrib><creatorcontrib>Charlap, Shlomo</creatorcontrib><creatorcontrib>Strom, Joel A.</creatorcontrib><title>Serotonergic Blockade Compared with Beta-Adrenergic Blockade in Systemic Hypertension: A Double-Blind Comparison of Ketanserin with Propranolol</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>The safety and efficacy of ketanserin, a competitive serotonin blocking agent, and Propranolol were compared in 33 patients with mild to moderate hypertension (sitting diastolic blood pressure {DBP} 95–115 mm Hg) using a placebo run‐in, randomized, double‐blind, parallel study design. All patients received placebo for 4 weeks, then were randomized to receive increasing doses of either ketanerin (20, 40 mg twice daily) or propranolol (40, 80 mg twice daily) to achieve a goal sitting DBP <90 mm Hg. Patients not achieving the goal blood pressure with either drug as monotherapy, received the other drug in combination. At the end of the active monotherapy phase (week 10 of the study), propranolol demonstrated a greater decrease in DBP from baseline, as compared to ketanserin (−7.9 ± 10.9 mm Hg with propranolol, P < 0.05; —1.0 ± 7.2 mm Hg with ketanserin, P = NS). Four out of 16 patients achieved goal response on propranolol, compared to 3/17 for ketanserin. With combination treatment, 9/18 patients reached the goal response; the addition of propranolol to ketanserin in non‐responders resulted in further reduction of sitting DBP of −10.3 ± 6.3 compared to monotherapy (P < 0.001), while the addition of ketanserin to non‐responders produced no significant response in sitting DBP. Propranolol showed a consistent effect in slowing heart rate. Ketanserin displayed less frequent side effects than propranolol. Propranolol used twice daily appears to be more effective than twice daily ketanserin use in patients with mild to moderate hypertension.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Adult</subject><subject>Bleeding Time</subject><subject>Blood Platelets - drug effects</subject><subject>Blood Pressure - drug effects</subject><subject>Double-Blind Method</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Ketanserin - blood</subject><subject>Ketanserin - pharmacokinetics</subject><subject>Ketanserin - therapeutic use</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Propranolol - blood</subject><subject>Propranolol - pharmacokinetics</subject><subject>Propranolol - therapeutic use</subject><subject>Random Allocation</subject><subject>Serotonin Antagonists - therapeutic use</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkc9u1DAYxC1EVZbCIyBFHLgl-F_iuCd2A3RbVlCpRRwtO_kC3iZxamfV3afglUnYaA_cONnyzPwszSD0luCEYEzfbxOSpjTmGeYJkXmeDAYzQmmyf4YWJ-k5WmAsSUwFxi_QyxC2GJOMp-QcnVOJRUrkAv2-A-8G14H_acto1bjyQVcQFa7ttYcqerLDr2gFg46XlYd_bbaL7g5hgHZ8XB968AN0wbruMlpGH93ONBCvGttVM88G10Wujr6MvC6AH-N_-bfe9V53rnHNK3RW6ybA6_m8QN8_f7ov1vHm29V1sdzEJceSxrWoQPKMMl0bQ0UG1GDDKCmJqUvKoMaGl1RKYBkQXlHMNK1NlYIUOeM4Zxfo3ZHbe_e4gzCo1oYSmkZ34HZBiVxwwsVkvDwaS-9C8FCr3ttW-4MiWE1rqK2aKldT5WpaQ81rqP0YfjP_sjMtVKfoXP-ofzjqT7aBw3-Q1U1xu56uIyI-Iuy4w_6E0P5BZYKJVP34eqVEcZ9JfrNRgv0BzcCsCA</recordid><startdate>198811</startdate><enddate>198811</enddate><creator>Okin, Stuart</creator><creator>Huberfeld, Seymour I.</creator><creator>Frishman, William H.</creator><creator>Soberman, Judith</creator><creator>Laifer, Larry</creator><creator>Greenberg, Steven</creator><creator>Lapsker, Jeanne</creator><creator>Charlap, Shlomo</creator><creator>Strom, Joel A.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198811</creationdate><title>Serotonergic Blockade Compared with Beta-Adrenergic Blockade in Systemic Hypertension: A Double-Blind Comparison of Ketanserin with Propranolol</title><author>Okin, Stuart ; Huberfeld, Seymour I. ; Frishman, William H. ; Soberman, Judith ; Laifer, Larry ; Greenberg, Steven ; Lapsker, Jeanne ; Charlap, Shlomo ; Strom, Joel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4092-f7de94623afbb276e2b0b321c1bfc23ef0b4c299e36e14d203a2fbd5e97834083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Adult</topic><topic>Bleeding Time</topic><topic>Blood Platelets - drug effects</topic><topic>Blood Pressure - drug effects</topic><topic>Double-Blind Method</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Ketanserin - blood</topic><topic>Ketanserin - pharmacokinetics</topic><topic>Ketanserin - therapeutic use</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Propranolol - blood</topic><topic>Propranolol - pharmacokinetics</topic><topic>Propranolol - therapeutic use</topic><topic>Random Allocation</topic><topic>Serotonin Antagonists - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okin, Stuart</creatorcontrib><creatorcontrib>Huberfeld, Seymour I.</creatorcontrib><creatorcontrib>Frishman, William H.</creatorcontrib><creatorcontrib>Soberman, Judith</creatorcontrib><creatorcontrib>Laifer, Larry</creatorcontrib><creatorcontrib>Greenberg, Steven</creatorcontrib><creatorcontrib>Lapsker, Jeanne</creatorcontrib><creatorcontrib>Charlap, Shlomo</creatorcontrib><creatorcontrib>Strom, Joel A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okin, Stuart</au><au>Huberfeld, Seymour I.</au><au>Frishman, William H.</au><au>Soberman, Judith</au><au>Laifer, Larry</au><au>Greenberg, Steven</au><au>Lapsker, Jeanne</au><au>Charlap, Shlomo</au><au>Strom, Joel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serotonergic Blockade Compared with Beta-Adrenergic Blockade in Systemic Hypertension: A Double-Blind Comparison of Ketanserin with Propranolol</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1988-11</date><risdate>1988</risdate><volume>28</volume><issue>11</issue><spage>1008</spage><epage>1016</epage><pages>1008-1016</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><abstract>The safety and efficacy of ketanserin, a competitive serotonin blocking agent, and Propranolol were compared in 33 patients with mild to moderate hypertension (sitting diastolic blood pressure {DBP} 95–115 mm Hg) using a placebo run‐in, randomized, double‐blind, parallel study design. All patients received placebo for 4 weeks, then were randomized to receive increasing doses of either ketanerin (20, 40 mg twice daily) or propranolol (40, 80 mg twice daily) to achieve a goal sitting DBP <90 mm Hg. Patients not achieving the goal blood pressure with either drug as monotherapy, received the other drug in combination. At the end of the active monotherapy phase (week 10 of the study), propranolol demonstrated a greater decrease in DBP from baseline, as compared to ketanserin (−7.9 ± 10.9 mm Hg with propranolol, P < 0.05; —1.0 ± 7.2 mm Hg with ketanserin, P = NS). Four out of 16 patients achieved goal response on propranolol, compared to 3/17 for ketanserin. With combination treatment, 9/18 patients reached the goal response; the addition of propranolol to ketanserin in non‐responders resulted in further reduction of sitting DBP of −10.3 ± 6.3 compared to monotherapy (P < 0.001), while the addition of ketanserin to non‐responders produced no significant response in sitting DBP. Propranolol showed a consistent effect in slowing heart rate. Ketanserin displayed less frequent side effects than propranolol. Propranolol used twice daily appears to be more effective than twice daily ketanserin use in patients with mild to moderate hypertension.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>2907519</pmid><doi>10.1002/j.1552-4604.1988.tb03122.x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2700 |
| ispartof | Journal of clinical pharmacology, 1988-11, Vol.28 (11), p.1008-1016 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adrenergic beta-Antagonists - therapeutic use Adult Bleeding Time Blood Platelets - drug effects Blood Pressure - drug effects Double-Blind Method Electrocardiography Female Heart Rate - drug effects Humans Hypertension - drug therapy Hypertension - physiopathology Ketanserin - blood Ketanserin - pharmacokinetics Ketanserin - therapeutic use Male Middle Aged Propranolol - blood Propranolol - pharmacokinetics Propranolol - therapeutic use Random Allocation Serotonin Antagonists - therapeutic use |
| title | Serotonergic Blockade Compared with Beta-Adrenergic Blockade in Systemic Hypertension: A Double-Blind Comparison of Ketanserin with Propranolol |
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