Inactivation of β-lactamases from Enterobacter cloacae by monophosphams

Amongst the monocyclic β-lactam antibiotics, selected monophosphams were potent mechanism-based inactivators of the P99 and E2 cephalosporinases of Enterobacter cloacae. Inhibition of these enzymes was time-dependent with second order rate constants for inactivation of 100,000 to 20,000,000 1/mole/m...

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Veröffentlicht in:	Journal of antimicrobial chemotherapy 1988-12, Vol.22 (6), p.801-809
Hauptverfasser:	Bush, Karen, Smith, S. A., Tanaka, S. K., Bonner, D. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents beta-Lactamase Inhibitors beta-Lactamases - isolation & purification Biological and medical sciences Cephalosporinase - isolation & purification Enterobacter - enzymology Enterobacteriaceae - enzymology Medical sciences Microbial Sensitivity Tests Monobactams - pharmacology Organophosphorus Compounds - pharmacology Pharmacology. Drug treatments
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