Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat
Dynorphin is present within perikarya of the lateral hypothalamus (LH) and perifornical nucleus (PeF), and within nerve terminals of the central nucleus of the amygdala, central grey, parabrachial nucleus, and the dorsal vagal complex (nucleus of the solitary tract and dorsal motor nucleus of the va...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1988, Vol.9 (5), p.1121-1127 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | Zardetto-Smith, Andrea M. Moga, Margaret M. Magnuson, Debra J. Gray, Thackery S. |
| description | Dynorphin is present within perikarya of the lateral hypothalamus (LH) and perifornical nucleus (PeF), and within nerve terminals of the central nucleus of the amygdala, central grey, parabrachial nucleus, and the dorsal vagal complex (nucleus of the solitary tract and dorsal motor nucleus of the vagus). Each of these nuclei receive efferent projections from the LH and PeF. In this study, the possibility that dynorphin cells with LH and PeF innervate each of these nuclei was investigated using a combined retrograde tracing-immunofluorescence technique. As enkephalinergic perikarya have also been localized to LH and PeF, peptide E (an enkephalin precursor fragment) was also studied for comparison. Following injections of fast blue into the central nucleus, parabrachial nucleus, central grey, and dorsal vagal complex, numerous retrogradely-labeled dynorphin-immunoreactive neurons were present within the LH and PeF. In comparison, retrogradely-labeled peptide E-immunoreactive cells were infrequently observed. These results suggest the LH and PeF to be a major source of dynorphin to the forebrain and brainstem. |
| doi_str_mv | 10.1016/0196-9781(88)90099-X |
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Each of these nuclei receive efferent projections from the LH and PeF. In this study, the possibility that dynorphin cells with LH and PeF innervate each of these nuclei was investigated using a combined retrograde tracing-immunofluorescence technique. As enkephalinergic perikarya have also been localized to LH and PeF, peptide E (an enkephalin precursor fragment) was also studied for comparison. Following injections of fast blue into the central nucleus, parabrachial nucleus, central grey, and dorsal vagal complex, numerous retrogradely-labeled dynorphin-immunoreactive neurons were present within the LH and PeF. In comparison, retrogradely-labeled peptide E-immunoreactive cells were infrequently observed. These results suggest the LH and PeF to be a major source of dynorphin to the forebrain and brainstem.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(88)90099-X</identifier><identifier>PMID: 2469062</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amygdala ; Amygdala - anatomy & histology ; Animals ; Axonal Transport ; Biological and medical sciences ; Brain Stem - anatomy & histology ; Brainstem ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Dynorphin ; Dynorphins - analysis ; Efferent Pathways - anatomy & histology ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Hypothalamic Area, Lateral - anatomy & histology ; Lateral hypothalamus ; Male ; Rat ; Rats - anatomy & histology ; Vertebrates: nervous system and sense organs</subject><ispartof>Peptides (New York, N.Y. : 1980), 1988, Vol.9 (5), p.1121-1127</ispartof><rights>1988</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c363t-83c61230265411828cb041ee8859a3fed5d6d3cf62dd75c4dde48cc5398da7853</citedby><cites>FETCH-LOGICAL-c363t-83c61230265411828cb041ee8859a3fed5d6d3cf62dd75c4dde48cc5398da7853</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/019697818890099X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6727858$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2469062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zardetto-Smith, Andrea M.</creatorcontrib><creatorcontrib>Moga, Margaret M.</creatorcontrib><creatorcontrib>Magnuson, Debra J.</creatorcontrib><creatorcontrib>Gray, Thackery S.</creatorcontrib><title>Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Dynorphin is present within perikarya of the lateral hypothalamus (LH) and perifornical nucleus (PeF), and within nerve terminals of the central nucleus of the amygdala, central grey, parabrachial nucleus, and the dorsal vagal complex (nucleus of the solitary tract and dorsal motor nucleus of the vagus). Each of these nuclei receive efferent projections from the LH and PeF. In this study, the possibility that dynorphin cells with LH and PeF innervate each of these nuclei was investigated using a combined retrograde tracing-immunofluorescence technique. As enkephalinergic perikarya have also been localized to LH and PeF, peptide E (an enkephalin precursor fragment) was also studied for comparison. Following injections of fast blue into the central nucleus, parabrachial nucleus, central grey, and dorsal vagal complex, numerous retrogradely-labeled dynorphin-immunoreactive neurons were present within the LH and PeF. In comparison, retrogradely-labeled peptide E-immunoreactive cells were infrequently observed. These results suggest the LH and PeF to be a major source of dynorphin to the forebrain and brainstem.</description><subject>Amygdala</subject><subject>Amygdala - anatomy & histology</subject><subject>Animals</subject><subject>Axonal Transport</subject><subject>Biological and medical sciences</subject><subject>Brain Stem - anatomy & histology</subject><subject>Brainstem</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Dynorphin</subject><subject>Dynorphins - analysis</subject><subject>Efferent Pathways - anatomy & histology</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypothalamic Area, Lateral - anatomy & histology</subject><subject>Lateral hypothalamus</subject><subject>Male</subject><subject>Rat</subject><subject>Rats - anatomy & histology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9rFEEQxRtR4ib6DRTmIBIPE_v_VF8CEtQIC7mo5Nb0dtdkW2Z61u5eYb-9s9llj5pTUbxfFVXvEfKG0StGmf5ImdGt6YBdAnwwlBrT3j8jCwadaBXT5jlZnJCX5LyUX5RSKQ2ckTMutaGaL8jPpauY3dCsd5uprt3gxuibsEtT3qxjwvwwt9j3mDHV0tSpqWts3Lh7CDPbuBSaVXYxlYpjE9Ojml19RV70bij4-lgvyI8vn7_f3LbLu6_fbj4tWy-0qC0IrxkXlGslGQMOfkUlQwRQxokegwo6CN9rHkKnvAwBJXivhIHgOlDigrw_7N3k6fcWS7VjLB6HwSWctsV20ElGzf9BpgRTvDNPAJkUkosZlAfQ56mUjL3d5Di6vLOM2n1Adu--3btvAexjQPZ-Hnt73L9djRhOQ8dEZv3dUXfFu6HPLvlYTpju-Pw3zNj1AcPZ3T8Rsy0-YvIYYkZfbZjiv-_4C3g-rH0</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Zardetto-Smith, Andrea M.</creator><creator>Moga, Margaret M.</creator><creator>Magnuson, Debra J.</creator><creator>Gray, Thackery S.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1988</creationdate><title>Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat</title><author>Zardetto-Smith, Andrea M. ; Moga, Margaret M. ; Magnuson, Debra J. ; Gray, Thackery S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c363t-83c61230265411828cb041ee8859a3fed5d6d3cf62dd75c4dde48cc5398da7853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Amygdala</topic><topic>Amygdala - anatomy & histology</topic><topic>Animals</topic><topic>Axonal Transport</topic><topic>Biological and medical sciences</topic><topic>Brain Stem - anatomy & histology</topic><topic>Brainstem</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Dynorphin</topic><topic>Dynorphins - analysis</topic><topic>Efferent Pathways - anatomy & histology</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypothalamic Area, Lateral - anatomy & histology</topic><topic>Lateral hypothalamus</topic><topic>Male</topic><topic>Rat</topic><topic>Rats - anatomy & histology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zardetto-Smith, Andrea M.</creatorcontrib><creatorcontrib>Moga, Margaret M.</creatorcontrib><creatorcontrib>Magnuson, Debra J.</creatorcontrib><creatorcontrib>Gray, Thackery S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zardetto-Smith, Andrea M.</au><au>Moga, Margaret M.</au><au>Magnuson, Debra J.</au><au>Gray, Thackery S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1988</date><risdate>1988</risdate><volume>9</volume><issue>5</issue><spage>1121</spage><epage>1127</epage><pages>1121-1127</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Dynorphin is present within perikarya of the lateral hypothalamus (LH) and perifornical nucleus (PeF), and within nerve terminals of the central nucleus of the amygdala, central grey, parabrachial nucleus, and the dorsal vagal complex (nucleus of the solitary tract and dorsal motor nucleus of the vagus). Each of these nuclei receive efferent projections from the LH and PeF. In this study, the possibility that dynorphin cells with LH and PeF innervate each of these nuclei was investigated using a combined retrograde tracing-immunofluorescence technique. As enkephalinergic perikarya have also been localized to LH and PeF, peptide E (an enkephalin precursor fragment) was also studied for comparison. Following injections of fast blue into the central nucleus, parabrachial nucleus, central grey, and dorsal vagal complex, numerous retrogradely-labeled dynorphin-immunoreactive neurons were present within the LH and PeF. In comparison, retrogradely-labeled peptide E-immunoreactive cells were infrequently observed. These results suggest the LH and PeF to be a major source of dynorphin to the forebrain and brainstem.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2469062</pmid><doi>10.1016/0196-9781(88)90099-X</doi><tpages>7</tpages></addata></record> |
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| subjects | Amygdala Amygdala - anatomy & histology Animals Axonal Transport Biological and medical sciences Brain Stem - anatomy & histology Brainstem Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Dynorphin Dynorphins - analysis Efferent Pathways - anatomy & histology Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Hypothalamic Area, Lateral - anatomy & histology Lateral hypothalamus Male Rat Rats - anatomy & histology Vertebrates: nervous system and sense organs |
| title | Lateral hypothalamic dynorphinergic efferents to the amygdala and brainstem in the rat |
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