Inhibition of HIV and virus replication by polysulphated polyxylan: HOE/BAY 946, a new antiviral compound

Xylanpoly-(hydrogen sulphate) disodium salt with a molecular weight of about 6000 daltons (HOE/BAY 946) completely inhibited syncytium formation induced by the infection of T lymphocytes with HIV as well as viral replication at concentrations above 25 micrograms/ml. This dose was found to be inhibit...

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Veröffentlicht in:	AIDS (London) 1988-12, Vol.2 (6), p.449-457
Hauptverfasser:	Biesert, L, Suhartono, H, Winkler, I, Meichsner, C, Helsberg, M, Hewlett, G, Klimetzek, V, Mölling, K, Schlumberger, H D, Schrinner, E
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Animals Antiviral Agents - pharmacology Bone Marrow - drug effects Bone Marrow Cells Cell Survival - drug effects Female HIV - drug effects HIV - enzymology HIV - physiology HIV-1 - drug effects HIV-1 - physiology HIV-2 - drug effects HIV-2 - physiology human immunodeficiency virus Humans In Vitro Techniques Interleukin-1 - biosynthesis Lymphocytes - cytology Lymphocytes - drug effects Macrophages - drug effects Macrophages - metabolism Mice Oxygen - metabolism Pentosan Sulfuric Polyester Polysaccharides - pharmacology Reverse Transcriptase Inhibitors Virus Replication - drug effects
Online-Zugang:	Volltext
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