Effect of Propranolol on Early Postischemia Arrhythmias and Noradrenaline and Potassium Release of Ischemic Myocardium in Anesthetized Pigs

In anesthetized open-chest pigs, DL- or D-propranolol (1 mg/kg i.v.) was administered 15 min prior to ligation of the left anterior descending coronary artery (LAD) about halfway from its origin. Sequential myocardial tissue samples were obtained before and after LAD occlusion. The samples were anal...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1988, Vol.12 Suppl 1, p.S41-47
Hauptverfasser:	Knopf, H, McDonald, F M, Bischoff, A, Hirche, Hj, Addicks, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animals Arrhythmias, Cardiac - drug therapy Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - mortality Blood Pressure - drug effects Catecholamines - metabolism Coronary Disease - complications Coronary Vessels - physiology Female Heart Rate - drug effects Male Myocardium - metabolism Norepinephrine - metabolism Potassium - metabolism Propranolol - therapeutic use Swine
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